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DMM Journal

@DMM_Journal

Disease Models & Mechanisms - discovery for human health. A @Co_Biologists Open Access journal that publishes human disease research.

 Cambridge, UK
journals.biologists.com/dmm
Joined September 2009
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*** Call for papers deadline extended *** Submit your latest #Paediatric #GeneticDiseases paper to be included in our next special issue. The deadline has been extended to 7 December 2026. Find out more today 👇️ tinyurl.com/3b8zscaz
Call for papers - Special Issue - Paediatric Genetic Diseases: Models, Mechanisms and Therapies. Edited by James Amatruda, Ross Cagan and Elaine Mardis. Extended deadline: 7 December 2026.

ALT Call for papers - Special Issue - Paediatric Genetic Diseases: Models, Mechanisms and Therapies. Edited by James Amatruda, Ross Cagan and Elaine Mardis. Extended deadline: 7 December 2026.

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Stress in the metastatic journey – the role of cell communication and clustering in breast cancer progression and treatment resistance. This #BreastCancerAwarenessMonth, check out the Research Article by Grasset et al. doi.org/10.1242/dmm.050542 #BCAM
Stress in the metastatic journey – the role of cell communication and clustering in breast cancer...

Stress in the metastatic journey – the role of cell communication and clustering in breast cancer...

Summary: This Review examines the multiple challenges cancer cells encounter during metastasis and therapeutic interventions, with a focus on strategies adopted by cancer cells in the context of...

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There is still plenty of time to submit your latest #Paediatric #GeneticDiseases paper to be included in our next special issue. Deadline: 7 December 2026. Find out more 👇️ tinyurl.com/yp872wp5
Image from DMM Journal (@DMM_Journal)
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A knockout #MouseModel reveals that CRPPA deficiency is associated with mitochondrial dysfunction involving the cAMP-PKA-DRP1 pathway. Read the article by Jihang Luo: doi.org/10.1242/dmm.052890
Electron microscopy of the skeletal muscle in the lower limbs, cardiac tissue, brain tissue and ocular tissue of mice revealed mitochondrial structural abnormalities in the dyC/dyC mice compared to WT mice.

ALT Electron microscopy of the skeletal muscle in the lower limbs, cardiac tissue, brain tissue and ocular tissue of mice revealed mitochondrial structural abnormalities in the dyC/dyC mice compared to WT mice.

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A bioengineered platform reveals progressive impairment of skeletal muscles by metabolic dysfunction-associated steatotic liver disease-derived factors. Check out the Research Article by Armando Cortés-Reséndiz & co: doi.org/10.1242/dmm.052820
Schematic representation of construct fabrication and experimental timeline of the model.

ALT Schematic representation of construct fabrication and experimental timeline of the model.

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Check out the #FirstPerson interview with Armando, a PhD student in the lab of Javier Ramón-Azcón at Institute for Bioengineering of Catalonia (IBEC), developing human in vitro models to investigate complex disease mechanisms and organ–organ interactions. doi.org/10.1242/dmm.053137
Armando Cortés-Reséndiz

ALT Armando Cortés-Reséndiz

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We are delighted to support the Milner Therapeutics Institute seminar series. Don't miss the next seminar on 18 November, with a focus on #neurodegeneration. In the meantime, read DMM's neurodegeneration subject collection: journals.biologists.com/dmm/…
Milner Therapeutics Institute (@TheMilnerInst) profile pictureMilner Therapeutics Institute@TheMilnerInstOct 27
Milner Seminar: Focus on neurodegeneration 🧠 🗓️ 18 November ⏰ 4-5pm 📍 Jeffrey Cheah Biomedical Centre Speakers: Maura Malpetti, Department of Clinical Neurosciences and John Skidmore, @ALBORADA_DDI. Special thanks to our sponsors @DMM_Journal! 🔗 ow.ly/VXhT50ZRmce
Image from Milner Therapeutics Institute (@TheMilnerInst)
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Registration is now open to attend our 2027 Journal meeting on #metabolism, organised by Sally Dunwoodie, Irene Miguel-Aliaga @FlyGutLab, Satdarshan [Paul] Singh Monga & Hans-Georg Sprenger Apply to attend at tinyurl.com/k56s3rk4 #BiologistsMetabolism
Metabolism: From Cellular Mechanisms to Development and Disease 21 – 23 June 2027, St Mary’s Marylebone, London, UK

ALT Metabolism: From Cellular Mechanisms to Development and Disease 21 – 23 June 2027, St Mary’s Marylebone, London, UK

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We are pleased to be a @reviewcommons.org affiliate journal. Our Academic Editors are happy to consider transfers from Review Commons. Find out more about the platform and why authors chose it: embo.org/features/why-i-chos…
Why I chose Review Commons – Features – EMBO

Why I chose Review Commons – Features – EMBO

Four scientists shared their experience on the benefits of journal-agnostic peer review.

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For your #WeekendRead - Tracey Murray Stewart and colleagues present an improved mouse model of #SnyderRobinsonSyndrome, providing a robust platform for therapy testing. Read and share the article for free doi.org/10.1242/dmm.052953
Effects of the SmsG56S allele on regional protein expression in the brain

ALT Effects of the SmsG56S allele on regional protein expression in the brain

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Today is #BreastCancerAwareness #WearItPink day. In our interview with Funmi Olopade, she talks about her serendipitous research path, improving care for breast cancer patients and the heroism of women in genetics. doi.org/10.1242/dmm.049198
Doing better and being better in breast cancer care: an interview with Funmi Olopade

Doing better and being better in breast cancer care: an interview with Funmi Olopade

Dr Olufunmilayo (Funmi) I. Olopade, FAACR, is the Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics and Director of the Center for Clinical Cancer Genetics and Global...

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Claes Fryklund & co use longitudinal metabolic phenotyping to identify a fixed-dose streptozotocin protocol that produces a stable type 2 diabetes-like phenotype in high-fat-diet-fed mice. Check out this article for free in DMM: doi.org/10.1242/dmm.053071
Mathematical modelling of STZ intervention in mice. Schematic representation of the mathematical model structure.

ALT Mathematical modelling of STZ intervention in mice. Schematic representation of the mathematical model structure.

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‘Why is publishing so expensive?’ This year’s theme for #OAweek is #TheCostOfKnowledge - an opportunity to revisit the Editorial where DMM, a fully Open Access journal, is transparent about its publishing finances: journals.biologists.com/dmm/…
‘Why is publishing so expensive?’

‘Why is publishing so expensive?’

For many of us who work in scientific publishing, the title of this Editorial is a question we hear all the time when we're out talking to academics. And it's a perfectly reasonable one. After all,...

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We're still celebrating #OAweek: Our subject collections of #openaccess reviews and research articles make it easy to browse your favourite topics: journals.biologists.com/dmm/…
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Ignacio Simó and colleagues find polyQ-expanded ataxin-3 is associated with mitochondrial alterations in #MachadoJosephDisease Read the Research Article for free: doi.org/10.1242/dmm.052757
Primary cortical neuron cultures from CMVMJD135 and WT embryos and analysis of mitochondrial and metabolic markers.

ALT Primary cortical neuron cultures from CMVMJD135 and WT embryos and analysis of mitochondrial and metabolic markers.

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To find out more about this research, check out the #FirstPerson interview with Ignacio, a postdoc in the lab of @AngelaSLaird at Macquarie University, investigating mitochondrial dysfunction, cellular metabolism and m6A RNA regulation doi.org/10.1242/dmm.053121
Image from DMM Journal (@DMM_Journal)
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Celebrate #OAweek 2026 with DMM. Learn more about DMM's Open Access policies journals.biologists.com/dmm/…
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Female-specific alterations in insulin dynamics are associated with glucose tolerance in a Glut1DS mouse model Check out the article by Tamio Furuse & co: doi.org/10.1242/dmm.052836
Glucose-related features measured in clinical blood chemistry test.

ALT Glucose-related features measured in clinical blood chemistry test.

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Thank you to organisers James Amatruda, Pratiti (Mimi) Bandopadhayay, Ana Banito and Elaine Mardis and everyone who joined us last week for our meeting on Innovative Preclinical Models for Pediatric Cancer Research #DMM2026cancer
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For your #WeekendRead this #BreastCancerAwarenessMonth - Functional exploration of copy number alterations in a Drosophila model of triple-negative breast cancer. Read the article by Diaz et al: doi.org/10.1242/dmm.050191
Functional exploration of copy number alterations in a Drosophila model of triple-negative breast...

Functional exploration of copy number alterations in a Drosophila model of triple-negative breast...

Editor's choice: Modeling of triple-negative breast cancer (TNBC) is challenging owing to the predominance of copy number variations. Here, we combined computational and Drosophila modeling to...

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Eduardo Vieira Neto and colleagues characterise the #cardiomyopathy developed by a mouse model carrying a mutation in the β-subunit of mitochondrial trifunctional protein Read and share for free: doi.org/10.1242/dmm.052921
Myocardial interstitial fibrosis in a homozygous βTFP-deficient mouse with the highest collagen fraction.

ALT Myocardial interstitial fibrosis in a homozygous βTFP-deficient mouse with the highest collagen fraction.

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