JAMA Ophthalmology

💡 Delayed #BreastCancer metastasis to the choroid was identified 31 years after treatment for ductal carcinoma in situ, highlighting that #ChoroidalMetastasis should remain in the differential diagnosis of amelanotic choroidal lesions. ja.ma/4BzCmAs

🧬 Among individuals with adult-onset #RetinitisPigmentosa, variants affecting the long retinal-enriched PRKCZ isoform were associated with retinal degeneration, supporting PRKCZ as a potentially clinically relevant diagnostic gene. ja.ma/47LJfRG

This case report describes a diagnosis of lipemia retinalis in a woman aged 27 years with creamy discoloration of the retinal vessels on fundus examination and markedly elevated serum triglyceride levels. ja.ma/4zBJWsE

📊 After tamoxifen initiation, ophthalmic encounters were uncommon and retinal #OCT or fundus photography was rare, and among patients with #BreastCancer, tamoxifen was not associated with greater adjusted 12-month ophthalmic use vs aromatase inhibitors. ja.ma/4znmNKQ

📊 Rural patients with #Glaucoma had similar #VisualField testing but less frequent retinal nerve fiber layer #OCT monitoring vs urban patients, and #Medicaid insurance was associated with lower odds of regular testing across both modalities. ja.ma/4zY4coh

Case report of a patient aged 37 years with asymptomatic bilateral drusen discusses how adaptive optics transscleral flood illumination imaging enabled in vivo has the potential to detect subtle retinal pigment epithelial changes in patients with drusen. ja.ma/47joTyW

This case report discusses bilateral central retinal artery occlusion (CRAO) in a young adult with no cardiovascular history who presented with bilateral vision loss 3 days after recreational cocaine use. ja.ma/3VPsNgi

A 31-year-old woman from Guam with no known medical history was referred by an ophthalmologist to a US cornea clinic for bilateral progressive blurred vision and corneal opacities. What would you do next? ja.ma/4yiYD2E

A 60-year-old man presented with progressive vision loss over several weeks in his right eye, noting a dark spot in his central vision and metamorphopsia. What would you do next? ja.ma/47joTPs

Ultra-long-distance robotic-assisted subretinal injection for #SubmacularHemorrhage was completed across approximately 4000 km without intraoperative complications or serious postoperative adverse events in a single-case report. ja.ma/4zxLfc2

Among patients with #StargardtDisease, daily oral gildeuretinol acetate was associated with slower growth of retinal atrophic lesions vs the untreated group, with no treatment-related serious adverse events observed. ja.ma/4ypuwGS

📣 JAMA and the JAMA Network journals are issuing a call for papers on Women's Health. ➡️ Manuscripts submitted by November 15, 2026, will have the best chance for consideration for simultaneous publication on International Women’s Day. 🔗 Learn more: ja.ma/48dtUcw

In #HighMyopia, 3-dimensional globe shape on #MRI identified 5 remodeling trajectories over 15 years, and focal deformation was associated with worse structural outcomes than preserved sphericity despite similar axial elongation. ja.ma/4zyJkUt

Heterozygous EFEMP1 p.Arg140Trp variants were associated with late-onset #RetinalDegeneration that preferentially affected the periphery and rods, while relatively sparing central macular structure and function. ja.ma/3VPNTew

In #PediatricVision screening, the HOTV test yielded better uncorrected visual acuity outcomes than tumbling E, with the largest differences in children younger than 8 years. ja.ma/47DwTel

This Special Communication reviews the distinct features of thyroid eye disease, the limitations of the currently available metrics, and introduces the Innovate TED Initiative to develop new outcome metrics. ja.ma/3VMB8kV

For #Glaucoma, #OpticalCoherenceTomographyAngiography vessel density and #OpticalCoherenceTomography retinal nerve fiber layer changes preceded #VisualField progression ja.ma/4zCTfIR

Among children with #Myopia, virtual reality–based digital defocus vision training plus single-vision spectacles was associated with less axial elongation and less myopic progression at 6 months vs spectacles alone. ja.ma/4zv53fX

Among US children with #Myopia, highly aspherical lenslet spectacle lenses reduced myopia progression and axial elongation over 24 months vs single-vision spectacle lenses. ja.ma/47RZ8pr

For neovascular #AgeRelatedMacularDegeneration, early subretinal fluid absence and lower baseline anatomic measures were associated with sustained faricimab every-12-week or every-16-week dosing through 2 years. ja.ma/4zuvQsO