Lab Head and Medical Oncologist at the University of Melbourne and Peter MacCallum Cancer Centre. Snow Fellow. 2023 ASCO Education Chair.
Melbourne, Australia
Joined September 2014
- Tweets648
- Following434
- Followers1.5K
- Likes1.7K
Pinned Tweet
Delighted to share our new paper, published today in @Nature , led by @AprilCWatt and @AntonioAhnNZ at the @PeterMacCC and The University of Melbourne @uommedia
Paper: nature.com/articles/s41586-0…
Shom Goel retweeted
Comprehensive review article by Sara Hurvitz @fredhutch on state of the art advances in MBC treatment, published in @NEJM. This is also a timely reference for MDs and scientists and to cite in papers, grants, presentations. @SusanGKomen @BCRFcure @ASCO @AACR @PIK3CApathbreak
nejm.org/doi/full/10.1056/NE…
A nice follow-up to our recent @Nature paper (@BarbMarte).
Nature has published a News & Views piece discussing the work: “The secret life of a cell-cycle gatekeeper of cancer.”
Very proud of the team. Interested to hear where these concepts go next.
nature.com/articles/d41586-0…
Shom Goel retweeted
CDK4/6 inhibitors, a cornerstone treatment for advanced HR+ breast cancer, were thought to work by reactivating Rb, a tumor suppressor that puts the brakes on cancer cell growth. In @Nature, ASPIRE Awardee @ShomGoel shows that isn’t the full story.
petermac.org/about-us/news-a…
Shom Goel retweeted
Epigenetics Update - Rb-driven transcription limits its tumour-suppressive effects in breast cancer u.epigenome.us/sX3waeUF
@AprilCWatt/ @AntonioAhnNZ and @shomgoel (@PeterMacCC/ @uommedia) in @Nature
#Epigenetics #pRB #Cancer #BreastCancer
---
epigenometech.com
Shom Goel retweeted
Excited to share our work, now in @Nature! Delighted to have co-led this study with co-first author @AntonioAhnNZ under the supervision of @shomgoel at @PeterMacCC @PeterMacRes and the University of Melbourne @uommedia
Open access:
nature.com/articles/s41586-0…
Thank you @PeterMacCC @PeterMacRes. We are very proud to work in one of the world's best cancer research hospitals.
Peter Mac researchers from @shomgoel's lab have uncovered why breast cancer treatment stops working for some patients.
Published in @Nature, the discovery could help develop new treatment combinations that work for longer and improve outcomes.
More: petermac.org/about-us/news-a…
This helps explain why CDK4/6 inhibition works so well with endocrine therapy, and may also explain why endocrine resistance mechanisms such as ESR1 mutations can drive resistance to the combination.
A terrific team effort, and very grateful to everyone who contributed. And many thanks to those who supported this work @SnowMedical @BCRFcure @TheMarkFdn
Thank you to @BCTrialsANZ for this tremendous honour. It was a pleasure to share the story of our work over the years during my talk, and to reconnect with many friends and colleagues in Brisbane. @PeterMacRes @PeterMacCC @SnowMedical
Congratulations @AprilCWatt on a great talk at @SABCSSanAntonio. Provided the first real explanation of why CDK4/6 inhibitors and endocrine therapy work together, with major implications for understanding resistance and therapy development.
Congratulations @AprilCWatt on a great talk at @SABCSSanAntonio. Provided the first real explanation of why CDK4/6 inhibitors and endocrine therapy work together, with major implications for understanding resistance and therapy development.
This is very interesting and in a way what could be predicted. Do you think there’s a desire to develop the drugs for this purpose?
Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @KellyLBolton lab! #ASH25
Five awesome posters on CDK4/6 resistance - single cell RNA-seq, 3D chromatin structure and ATAC-seq, new PDX models, and new targets. Feels like we are making real progress as different groups are converging on similar observations! @SABCS25 @SABCSSanAntonio
On my way! Looking forward to this session on resistance to cell cycle inhibitors in breast cancer. #SABCS25 @SABCSSanAntonio
🙌 hey #sabcs25, be sure to wake up early 🌅 tomorrow (Weds) for Dr. Yuki Matsunaga’s poster spotlight on how drug tolerant persister cells survive treatment with endocrine therapy and #CDK4/6 inhibitors! @utswcancer @UTSWMedCenter @SABCSSanAntonio
Shom Goel retweeted
Happy to have shared the stage with my esteemed colleagues @shomgoel @elmayermd @MOliveira_MD @AMJohnston1315 at #SABCS25 @SABCSSanAntonio on the changing landscape post-CDK4/6i and shared decision making with our patients. It was a great session! @LevineCancer
