Brain

We are pleased to announce that registration for the 2027 Brain Conference is now OPEN! The conference will be held on 12 March, 2027. Visit the website to view our speakers, register to attend and see information on abstract submissions: conference.guarantorsofbrain…

Gibson et al. analysed postmortem brains from over 7000 older adults. Lewy body pathology was present in more than one in four people, with anatomical distributions of pathology differing by sex and showing distinct associations with co-pathologies. shorturl.at/TR9LS

Hendriks et al. argue that data sharing safeguards should be tailored to the likelihood of reidentification and sensitive inferences, helping to maximize scientific value while protecting individuals and communities. shorturl.at/KPHJH

Using Bayesian analyses, Klingbeil et al. identify right frontal lesions and right-dominant structural disconnection in frontal cortico-subcortical circuits as key correlates of post-stroke depressive symptoms. shorturl.at/Lbsvy

Zanello et al. examine the life and achievements of Jean Bancaud who, together with Jean Talairach, pioneered SEEG. Although initially met with scepticism, the methodology they developed remains the cornerstone of preoperative epilepsy assessment today. shorturl.at/G0F1D

Not letting go: tRNA sequestration as a unifying mechanism driving synthetase-linked neuropathies New scientific commentary by James N Sleigh shorturl.at/itmq8

Morrison et al. examined immune cells in the blood and CSF of people with Guillain-Barré syndrome, and found that inflammatory T cells were enriched in the CSF and that IVIg treatment was associated with a shift towards anti-inflammatory T-cell states. shorturl.at/SAi85

Chen et al. show that rigid and repetitive behaviours occur across dementia syndromes, most prominently in behavioural variant FTD. These symptoms are linked to structural and functional changes in the brain’s reward hub, the nucleus accumbens. shorturl.at/KHS2h

Cederberg et al. present the results of a double-blind, placebo-controlled trial in patients with severe TBI, showing that treatment with Salovum® - a medical food supplement enriched with antisecretory factor - almost halved the 30-day mortality rate. shorturl.at/ww8Tv

Progress divides the room: patients, biology and the 2024 McDonald criteria New scientific commentary by Nikos Evangelou & Christopher Gilmartin shorturl.at/8YG81

November's issue of Brain is now online! academic.oup.com/brain/issue…

Chen et al. investigate the role of the cerebellum in social behaviour in early-stage behavioural variant frontotemporal dementia, and find that specific cerebellar regions work with cortical networks to support social understanding. shorturl.at/EFLut

Hayes et al. explore how Alzheimer’s pathology affects the relationship between vascular neuropathology and cognitive scores. shorturl.at/NHyQq

Rodrigo et al. review the structure and functions of the amygdala, highlighting its complex morphology and varied roles. They explore how its organisation differs across species and discuss its early involvement in several neurodegenerative diseases. shorturl.at/drLBj

Gonebale et al. review how E3 ubiquitin ligase dysfunction disrupts protein quality control and contributes to inherited peripheral neuropathies and progressive axonal degeneration. shorturl.at/MczyO

Zhang et al. identify the deubiquitinating enzyme OTUB2 as a key regulator of cGAS-STING signalling and neuroinflammation. Deletion or inhibition of OTUB2 ameliorated neuroinflammation and neurodegeneration in mouse models of ALS and ageing. shorturl.at/CJaxH

Wei et al. show that circadian rhythms in pain are driven by the molecular clock in sensory neurons. Cryptochrome proteins regulate sodium channel activity and nociceptor excitability, while stabilisation of cryptochromes reduces pain responses. shorturl.at/X1ceX

Narasimhan et al. show that humanized Cbln2 regulation alters cortical and striatal circuits in mice, enhancing prefrontal connectivity but impairing corticostriatal synaptic transmission and plasticity, with behavioural consequences relevant to autism. shorturl.at/4N9lf

Salmon et al. present global expert consensus recommendations for genetic testing and counselling for ALS, proposing tiered implementation frameworks that balance ethical, clinical, and health-system considerations to support global access to services. shorturl.at/33HBj

Thompson et al. examine KCNH1 variants associated with neurodevelopmental disorders and find that most exhibit gain-of-function effects that hyperpolarize the resting membrane potential. shorturl.at/2oEf6

In LGI1-antibody encephalitis, Ramanathan et al. identify immunotherapies associated with seizure resolution, reduced disability, and fewer relapses, and show how patient-rated outcome measures help define clinically significant disability. shorturl.at/Y1FMi