Join the movement, connect, share, and speed GPCR drug discovery. #GPCR Ecosystem. https://xitter.cf/t.co/jPzcdANDn1
Boston MA
Joined January 2020
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Obesity co-agonists hit amylin, GLP-1, and GIP at once. Profiling all three across cAMP and β-arrestin shows how one molecule splits its activity. AMY/CALCR, GLP1R, and GIPR assays from Eurofins DiscoverX: ecosystem.drgpcr.com/post/re… #DrGPCR #GPCR
Marsha Pierce (Midwestern University) teaches Introduction to GLP-1 Pharmacology at Dr. GPCR University Masterclass.
GLP-1 physiology, agonist mechanism of action, how the approved agents differ. Thu Oct 29, 10 AM ET.
ecosystem.drgpcr.com/gpcr-ma…
#DrGPCR #GPCR
One partner from first screen to development candidate. Eurofins Discovery, one of our ecosystem partners, covers GPCR drug discovery end to end, no handoffs. 30+ yrs expertise, 2,750+ assays.
ecosystem.drgpcr.com/post/dr…
#DrGPCR #GPCR #DrugDiscovery
Two hours out. GPCR Desensitization in Health and Disease with Adriano Marchese, 10 AM ET.
Homologous, heterologous, and the machinery behind both. Bring your questions.
ecosystem.drgpcr.com/gpcr-ma…
#DrGPCR #GPCR
Tomorrow at 10 AM ET: GPCR Desensitization in Health and Disease with Adriano Marchese.
Mechanisms, regulation of the machinery, therapeutic efficacy. Live, with Q&A.
ecosystem.drgpcr.com/gpcr-ma…
#DrGPCR #GPCR
Adriano Marchese (Medical College of Wisconsin) teaches GPCR Desensitization in Health and Disease at Dr. GPCR University Masterclass.
Homologous vs heterologous, and how the machinery is regulated. Thu Oct 22, 10 AM ET.
ecosystem.drgpcr.com/gpcr-ma…
#DrGPCR #GPCR
Happy to count Eurofins Discovery in the Dr. GPCR ecosystem: one partner for end-to-end GPCR drug discovery. Screening, selectivity, safety, biased signaling, deorphanization. 30+ yrs expertise, 2,750+ assays.
ecosystem.drgpcr.com/post/dr…
#DrGPCR #GPCR #DrugDiscovery
Two hours out. Biophysical Approaches to Orphan GPCR Drug Discovery with Dmitry Veprintsev, 10 AM ET.
ThermoBRET, G protein recruitment, Gi-CASE. Bring your questions.
ecosystem.drgpcr.com/gpcr-ma…
#DrGPCR #GPCR
Tomorrow at 10 AM ET: Biophysical Approaches to Orphan GPCR Drug Discovery with Dmitry Veprintsev.
Express the receptor, confirm engagement, measure function. Live, with Q&A.
ecosystem.drgpcr.com/gpcr-ma…
#DrGPCR #GPCR
Tomorrow at 11 AM ET / 8 AM PT.
Functional Volume Control with Dr. Terry Kenakin. In collaboration with @EurofinsDscvrx. Registration open until we go live. ecosystem.drgpcr.com/gpcr-we…
#DrGPCR #GPCR
ALT Dr. GPCR and Eurofins DiscoverX webinar card reading Live September 24, 11 AM ET / 8 AM PT.
Two days out. Functional volume control, live with Terry Kenakin. Thursday Sept 24, 11 AM ET / 8 AM PT.
Free. Live Q&A. Recording afterward. Bring your questions. ecosystem.drgpcr.com/gpcr-we…
#DrGPCR #GPCR
ALT Dr. GPCR and Eurofins DiscoverX webinar card reading Live September 24, 11 AM ET / 8 AM PT.
Two agonists can look alike in a sensitive assay and reverse in a less sensitive one. One runs on affinity, the other on efficacy. Terry Kenakin shows how volume control tells them apart. Sept 24, 11 AM ET / 8 AM PT. With @EurofinsDscvrx. ecosystem.drgpcr.com/gpcr-we…
#DrGPCR #GPCR
ALT Dr. GPCR and Eurofins DiscoverX webinar card reading The molecule did not change. The sensitivity of the system did.
A neutral antagonist may not be neutral. Turn the system up, induce constitutive activity, and latent inverse agonism shows up.
Terry Kenakin on functional volume control. Live Sept 24, 11 AM ET / 8 AM PT. With @EurofinsDscvrx. ecosystem.drgpcr.com/gpcr-we…
#DrGPCR #GPCR
ALT Dr. GPCR and Eurofins DiscoverX webinar card reading The molecule did not change. The sensitivity of the system did.
Volume control happens in vivo too. β-receptor density in the heart falls as heart failure worsens, so the same agonist does less. Terry Kenakin on tuning system sensitivity, live Sept 24, 11 AM ET / 8 AM PT. With @EurofinsDscvrx. ecosystem.drgpcr.com/gpcr-we…
#DrGPCR #GPCR
ALT Dr. GPCR and Eurofins DiscoverX webinar card reading The molecule did not change. The sensitivity of the system did.
A third of all approved drugs act on GPCRs, and every one began at a lab bench. Reliable reagents are where discovery quietly begins, or quietly breaks. Full story: ecosystem.drgpcr.com/post/wh… #GPCR #drgpcr
"Doomed before you even shoot the rabbit." Why GPCRs punish antibody programs early: low abundance, buried epitopes, near-identical family sequences. Full story: ecosystem.drgpcr.com/post/wh… #GPCR #drgpcr
Where is the line between an antagonist and a weak partial agonist? Evan O'Brien solved one molecule bound to the mu opioid receptor in both active and inactive states to find out. He presents at #DOT2026, our chat: ecosystem.drgpcr.com/post/gp…
#DrGPCR #GPCR
ALT Can One Molecule Be an Agonist and an Antagonist? Evan O'Brien, PhD, Johns Hopkins University.
GLP-1 strips fat, but muscle can go with it. Hailong Zhang's biased APJ agonist YJ-015 is built to help keep muscle while the weight drops. He presents at #DOT2026, and we spoke with him first: ecosystem.drgpcr.com/post/gp…
#DrGPCR #GPCR
ALT Keeping the Muscle When the Fat Comes Off. Hailong Zhang, PhD, Shanghai Yogar Therapeutics.
Unreliable antibodies do not just fail. They fail quietly, and cost months before anyone notices. Why honest characterization is the fix. Full story: ecosystem.drgpcr.com/post/wh… #GPCR #drgpcr
It's live. Jane Lamerdin and Gaurav Agrawal of Eurofins DiscoverX on physiological relevance, the assays that refuse to work, and why GPCRs are back at the front of drug discovery.
Watch: ecosystem.drgpcr.com/dr-gpcr…
#GPCR #DrGPCR
ALT Dr. GPCR Podcast cover card reading Physiological Relevance Is The Whole Game.
Where and when a GPCR signals inside the cell: endomembrane signaling on endosomes and the Golgi, resolved one molecule at a time.
@DavideCalebiro live this Thursday, 10 AM ET. Direct Q&A. ecosystem.drgpcr.com/gpcr-ma…
#DrGPCR #GPCR #DrGPCRUniversity
ALT Orange Dr. GPCR banner reading Signaling Follows Receptors Into Endosomes