Ryan Langlois (@LangloisLab) header
Ryan Langlois (@LangloisLab) profile picture

Ryan Langlois

@LangloisLab

Associate Professor of Microbiology and Immunology Lab interested in viral immunology, viral evolution, and virus host interactions

 Minneapolis, MN
langloislab.umn.edu/
Joined April 2015
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Photo by Ryan Langlois (@LangloisLab)Photo by Ryan Langlois (@LangloisLab)Photo by Ryan Langlois (@LangloisLab)Photo by Ryan Langlois (@LangloisLab)Photo by Ryan Langlois (@LangloisLab)Photo by Ryan Langlois (@LangloisLab)Photo by Ryan Langlois (@LangloisLab)Photo by Ryan Langlois (@LangloisLab)Photo by Ryan Langlois (@LangloisLab)Photo by Ryan Langlois (@LangloisLab)
Ryan Langlois retweeted
Sofia Moraes (@sofianmoraes) profile picture
Sofia Moraes@sofianmoraes5 Dec 2022
My 1st first-author manuscript is out in @eLife! This project started back in 2019 with the question “what makes a viral protein evolve a new function?” A thread: doi.org/10.7554/eLife.83893
Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus...

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus...

The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to present day.

elifesciences.org
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. @ShanleyRoach is the winner of the @umncbs 3 minute thesis competition!!! Super proud. She is also on the postdoc market!
Image from Ryan Langlois (@LangloisLab)
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Ryan Langlois retweeted
Anice Lowen (@anice_lowen) profile picture
Anice Lowen@anice_lowen21 Sep 2022
The Lowen Lab is recruiting post-docs! Join us at Emory University, Atlanta, to do exciting fundamental virology on influenza A viruses. Major research areas include viral evolution, transmission and virus-virus interactions.
Image from Anice Lowen (@anice_lowen)
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It’s been 987 days since the last #bingo with @LangloisLab. And while I usually don’t do bingo when I’m off campus, I made an exception for when the OG @Baric_Lab is in town.
Image from The Menachery Lab (@TheMenacheryLab)
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Excited to share that our paper on injury-induced lung tuft cells is out now in @eLife! This is the fruit of an awesome collaboration with @lab_xin. Congratulations to the all authors, especially co-first authors @barrjamie and Marilena Gentile! elifesciences.org/articles/7… (1/2)
Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines,...

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines,...

Influenza-induced pulmonary tuft cells are a heterogenous population and emerge independently of Type 2 and interferon signaling, and do not impact dysplastic epithelial regeneration.

elifesciences.org
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Thrilled to share a new review article from our lab and @JessicaFiegePhD in @MicrobioSoc JGV on the impacts of eliminating natural mouse virus from traditional lab mouse experiments: microbiologyresearch.org/con… 1/3
Embracing the heterogeneity of natural viruses in mouse studies

Embracing the heterogeneity of natural viruses in mouse studies

microbiologyresearch.org
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We discuss how viruses (and other microbes) from several exciting models (wild mice, dirty mice, rewilded mice, wildlings etc) impact homeostasis, disease, and subsequent infections. 2/3
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We also provide some suggestions for standardization/ways to cross compare these powerful new models. All of these models have huge strengths and I am excited to see where they go next! 3/3
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Ryan Langlois retweeted
Jacob Yount (@YountLabOSU) profile picture
Jacob Yount@YountLabOSU11 May 2022
Our new paper in Science Advances led by Adam Kenney showing that direct infection of cardiomyocytes by influenza virus drives cardiac complications of the flu. Special thanks to @LangloisLab for engineering a cardiomyocyte-attenuated virus. ♥️🫁🦠🐁science.org/doi/10.1126/scia…
Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

Direct heart infection, not systemic inflammation, drives influenza virus–associated cardiac pathology in IFITM3 KO mice.

science.org
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Ryan Langlois retweeted
Keir Balla (@keirballa) profile picture
Keir Balla@keirballa6 May 2022
I'm looking for RAs & scientists to help launch my lab @czbiohub! We discover and deploy zebrafish viruses to capture infection dialogs with visual and molecular precision. Join us in illuminating virus infection biology in toto. czbiohub.org/careers/ or contact me directly
Image from Keir Balla (@keirballa)
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Delighted to share a new story led by @ShanleyRoach out now in @JVirology journals.asm.org/doi/10.1128… We sought to evaluate the role of tuft cells during acute influenza infection. There were lots of fun surprises along the way... 1/5

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in...

Influenza A virus (IAV) is a respiratory infection in humans that can lead to a wide range of symptoms and disease severity. Respiratory infection can cause systemic inflammation and damage in the...

journals.asm.org
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Interestingly, while the baseline microbiome was different between wt and tuft cell KO mice flu infection drove similar changes increasing Proteobacteria. These data show how influenza impacts the microbiome independent of tuft cells or starting community composition 4/5
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This work was supported by @JessicaFiegePhD and @AFranOfScience and a wonderful collaboration with @Hunter_lab and @TaliaWiggen @ShanleyRoach fell in love with tuft cells during this project and will likely have some great pics to show! 5/5
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We are looking for #postdocs to study #RNAvirus pathogenesis and therapeutic development #academia #jobs #SARSCoV2 #COVID19 @UNCpublichealth
Image from Timothy Sheahan (@timothysheahan)
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The Keystone Meetings Respiratory Viruses:New Frontiers and Viral Immunity: Basic Mechanisms and Therapeutic Applications are rescheduled to June 29th. Mark your calendars and keep an eye for new opportunities to submit an abstract!
Image from Carolina B. Lopez (@CBLopezLab)
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Cohousing of dirty pet store mice infected with a multitude of pathogens leads to transmission of these agents to clean laboratory mice. @ChristinHerrma1 and @CadwellLab highlight study (bit.ly/3sYrE5P) by @lizfay20 et al. @LangloisLab. bit.ly/3FURife
Image from Journal of Experimental Medicine (@JExpMed)
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Playing dirty with virus transmission. @ChristinHerrma1 and @CadwellLab highlight study (bit.ly/3sYrE5P) by @lizfay20,@keirballa, @ShanleyRoach, @AFranOfScience, @LangloisLab and colleagues. bit.ly/3FURife #InfectiousDisease #HostDefense
Image from Journal of Experimental Medicine (@JExpMed)
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Herrmann @ChristinHerrma1 and Cadwell @CadwellLab highlight study by @lizfay20 et al. (bit.ly/3sYrE5P) that investigates viral infection dynamics by cohousing dirty pet store mice and rats with clean laboratory mice. bit.ly/3FURife #InfectiousDisease
Image from Journal of Experimental Medicine (@JExpMed)
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