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Science Advances

@ScienceAdvances

Science Advances is an open-access multidisciplinary journal, publishing impactful research papers and reviews in any area of science.

 AAAS - Washington, DC
science.org/journal/sciadv
Joined February 2014
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Suppression of the Lynx1 gene improved spontaneous motor recovery and rehabilitation efficacy after stroke in mice, researchers report in a new study. Lynx1 may represent a promising therapeutic target for augmenting dendritic plasticity after stroke. scim.ag/4zEXvaY
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Dion Dickman (@dion_synapse) profile picture
Dion Dickman@dion_synapseNov 11
Is the active zone scaffold RIM required at every synapse? Not even close. 🧠 Out now in @ScienceAdvances: RIM is essential at a high-Pr phasic synapse but largely dispensable at its tonic neighbor. Led by the fantastic Rebecca Stark and team! 👏 science.org/doi/10.1126/scia…
Input-specific deployment of the active zone scaffold RIM tunes synaptic release probability and...

Input-specific deployment of the active zone scaffold RIM tunes synaptic release probability and...

The multidomain scaffold RIM (Rab3-interacting molecule) is widely viewed as a broadly required organizer of the presynaptic active zone, clustering voltage-gated Ca2+ (Cav2) channels, priming...

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A new analysis identifies a set of environmental exposures that have an outsized impact on early life. scim.ag/4C15eSq
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An examination of interplanetary dust particles supports the longstanding but hard-to-prove theory that the Kuiper Belt is home to a reservoir of water that’s rich in “heavy” oxygen. scim.ag/4ixoXkZ
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U.S. households benefit when they accept buyouts by FEMA to relocate from flood-prone areas, new research finds. However, the analyses show that the extent of these benefits depends on race and socioeconomic status. scim.ag/4BPWtut
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New research suggests that identifying pathway-specific modes of recruiting actin regulators can help define how signal precision is maintained in dynamic tissue environments. Learn more this week in Science Advances: scim.ag/4BLBfh4
Section of a mouse neural tube stained with phalloidin to visualize filamentous actin protein. The formation of pathway-specific cytonemes, actin-based “highways” that guide delivery of morphogen and growth factor signals to distant target cells, remains largely undefined. Daly et al. analyzed the development of Sonic Hedgehog cytonemes and signaling sequences in mouse embryos, finding that repurposing cell adhesion molecule-related proteins BOC and CDON to recruit actin regulators promotes cytoneme elongation and precise information flow. Their study suggests that identifying pathway-specific modes of recruiting actin regulators can help define how signal precision is maintained in dynamic tissue environments. Credit: Christina Daly

ALT Section of a mouse neural tube stained with phalloidin to visualize filamentous actin protein. The formation of pathway-specific cytonemes, actin-based “highways” that guide delivery of morphogen and growth factor signals to distant target cells, remains largely undefined. Daly et al. analyzed the development of Sonic Hedgehog cytonemes and signaling sequences in mouse embryos, finding that repurposing cell adhesion molecule-related proteins BOC and CDON to recruit actin regulators promotes cytoneme elongation and precise information flow. Their study suggests that identifying pathway-specific modes of recruiting actin regulators can help define how signal precision is maintained in dynamic tissue environments. Credit: Christina Daly

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A new study finds a group of neurons within the lateral parabrachial nucleus of the brainstem respond to cold temperatures by releasing enkephalin, a neuropeptide that reduces pain signals. The results mark a potential therapeutic strategy for pain relief. scim.ag/4ixqkii
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A new toothbrush generates electricity through bristle movement to battle plaque-producing bacteria. scim.ag/3Wt6g9q
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Age reshapes how melanoma evolves, according to a new study showing that patient age alters natural selection on cancer-driving mutations. The same mutation can have different effects on the genetic evolution of melanoma depending on the patient’s age. scim.ag/3X5pLoF
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Thilo Hagendorff (@ThiloHagendorff) profile picture
Thilo Hagendorff@ThiloHagendorffNov 5
Our paper “Machine Psychology” is out in @ScienceAdvances. We argue that LLMs should be studied like participants in psychology experiments. Benchmarks measure performance. Behavioral experiments show how models reason and act. science.org/doi/10.1126/scia…
Machine psychology for language models

Machine psychology for language models

Large language models (LLMs) show increasingly advanced emergent capabilities and are being incorporated across various societal domains. Understanding their behavior and reasoning abilities is...

science.org
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Ozturk Lab (@Ozturk_Lab) profile picture
Ozturk Lab@Ozturk_LabNov 7
Our new paper "Prebiotic magnetite enables chirality-magnetic surface feedback" is just out at @ScienceAdvances. science.org/doi/10.1126/scia…
Prebiotic magnetite enables chirality-magnetic surface feedback

Prebiotic magnetite enables chirality-magnetic surface feedback

The emergence of biomolecular homochirality requires both an initial symmetry-breaking event and a mechanism to amplify and preserve a chiral imbalance. Magnetic minerals have been shown to function...

science.org
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Laura Roy Studios (@lauraroystudios) profile picture
Laura Roy Studios@lauraroystudiosNov 9
Kickstarting the week with great news: Honored to have illustrated the cover/interior figures for the latest issue of @ScienceAdvances! Visualizing ultrasound neural interfaces for acute spinal cord monitoring (Manbachi et al. @AManbachi, Johns Hopkins). ZBrush, Illustrator, PS
Image from Laura Roy Studios (@lauraroystudios)
Image from Laura Roy Studios (@lauraroystudios)
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A new study on hibernation shows early cellular changes in Alzheimer’s disease may be a natural adaptive process. Hibernation-induced inflammation is similar to the response in Alzheimer’s disease without amyloid beta accumulation or neurodegeneration. scim.ag/4sFHNtz
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A new study finds that stabilizing the interferon protein IFNAR1 restores T cell function, enhancing the efficacy of immunotherapies for colorectal cancer. scim.ag/4ioCEmj
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A new method can determine where people’s brains lie on the SuperAger to Alzheimer’s continuum. scim.ag/4BPm5ro
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The use of mercury by the ancient Maya for ceremonies, religious events, and decoration spread the pollutant even further throughout the Yucatán region than previously known. scim.ag/4zrLQw5
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Good conversation between two people involves “pink noise,” according to new research. This term refers to fluctuations in semantic similarities—alignments in speech patterns and word choice—across time scales during a chat. scim.ag/4eg9Cme
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Newly documented traces of hydrogen chloride—a stinky gas often produced by magmatism—in the Martian atmosphere corroborates emerging evidence that suggests the planet is still volcanically active. scim.ag/48EnCmp
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A new study describes the Multimodal Ultrasound System for Injury Care device, which helps visualize spinal cord structure and track blood flow speed and velocity after surgery. Learn more in this week’s issue of Science Advances: scim.ag/4sJDyxh
Artistic concept of the Multimodal Ultrasound System for Injury Care, or MUSIC device, which uses ultrasound to reveal the spinal cord’s inner structure after decompression surgery. Currently, direct observation of spinal cord physiology following spinal decompression surgery for acute spinal cord injury is challenging. Kerensky et al. designed the implantable MUSIC device to aid visualization of spinal cord structure and track blood flow speed and velocity after surgery. Their findings may enable postoperative spinal cord monitoring and management through sound-based ultrasound technology. Credit: Laura Roy, CMI / LauraRoyStudios.com

ALT Artistic concept of the Multimodal Ultrasound System for Injury Care, or MUSIC device, which uses ultrasound to reveal the spinal cord’s inner structure after decompression surgery. Currently, direct observation of spinal cord physiology following spinal decompression surgery for acute spinal cord injury is challenging. Kerensky et al. designed the implantable MUSIC device to aid visualization of spinal cord structure and track blood flow speed and velocity after surgery. Their findings may enable postoperative spinal cord monitoring and management through sound-based ultrasound technology. Credit: Laura Roy, CMI / LauraRoyStudios.com

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A new study shows that climate-driven shifts in plant community structure, rather than peat decomposition alone, may threaten the stability of peatland ecosystem functions in the future. scim.ag/4ix3p6V @yiqiluo
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