Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine.
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ALT A person rides a bicycle on a flat surface. The shadow cast on an orange background shows the person on a larger bicycle with clock faces as wheels.
ALT Successful hematopoietic cell transplantation (HCT) requires immunosuppression to prevent graft-versus-host disease (GVHD), but the choice of regimen may shape immune reconstitution and GVHD risk. DeWolf et al. analyzed the T cell repertoires of clinical trial participants who received either tacrolimus and methotrexate (Tac/MTX) or posttransplant cyclophosphamide, mycophenolate mofetil, and tacrolimus (PT-Cy) as GVHD prophylaxis after HCT. PT-Cy more profoundly depleted the T cell compartment, creating a bottleneck as depicted on the cover, which resulted in a less diverse T cell repertoire. This reduced diversity was associated with lower GVHD risk but higher risk of infection after transplant. These findings show that immunosuppressive regimens can shape the balance between beneficial and harmful outcomes of HCT. Credit: N. Burgess/Science Translational Medicine
ALT Four panels show microscopic images of parasites. The top row depicts individual parasites labeled DMSO, MCLZ, M4339, and PZQ, all in different postures. The bottom row displays corresponding close-up textures of each parasite's surface.
ALT A person rides a bicycle on a flat surface. The shadow cast on an orange background shows the person on a larger bicycle with clock faces as wheels.
ALT The cover illustration shows a man on a bicycle going about his daily activities as the shadow of time looms in the distance. Credit: Davide Bonazzi/Salzman Art