Changing your mind is the essence of living matter. https://nitter.gq/t.co/rRyV6gK4UT
Joined May 2024
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The US Department of Veterans Affairs has started investigating high-dose Pregnenolone (500-2000mg) alongside DHEA, as novel therapies for chronic pain management.
They have even gone so far as to describe the use of neurosteroids in this context as a potential “Therapeutic Breakthrough.”
Ray Peat vindicated once again.
If you ever forget to study for an exam, simply induce supraphysiological luck with unlimited coffee, sugar, thiamine, and microdose LSD.
Then pick random answers and hope for the best. Statistical probability is on your side.
Sugar activates my luck.
Something about carbs, especially fruit / sugar, turns on my antenna, allowing me to better connect with the universe / God / Energy.
Sugar maxxing for me =
-More synchronicities
-Heightened intuition
-Greater sense of connection
-More creativity and abstract thinking
-Increased optimism
-A stronger sense of purpose
-Feeling more in tune with the world around me
It's like turning up the signal on a radio. Everything just feels more connected.
To put it simply, Sugar activates my luck.
My theory is that energy attracts energy. The higher I can push my energy, the easier it is for me to connect with the energy around me.
Why did nobody tell me sooner that Utz hard pretzels have 0g fat and the cleanest ingredient list I’ve ever seen on a snack food?
Want to pharmacologically force photographic memory?
Crebinostat, Nicotine, and DNP
Nicotine strongly stimulates the calcium-dependent enzymes that produce cAMP.
DNP is neuroprotective in low doses, it engages parallel pathways that limit cAMP degradation.
These complementary actions amplify downstream histone acetylation, making memory-related genes more accessible for transcription.
However, HDAC enzymes would normally remove these acetyl groups, putting a break to how long chromatin remains accessible for transcription. This is where Crebinostat comes in.
By inhibiting HDAC, Crebinostat could help keep chromatin open for longer, prolonging the expression of genes such as BDNF, Arc, and Synapsin-1, supporting neuroplasticity and long-term memory consolidation.
Bromantane is one of those compounds that sounds overhyped. UNTIL you try it yourself and understand why people keep coming back to it.
An atypical stimulant that stands out as one of the most distinctive nootropics. A compound that can simultaneously boost productivity, mental endurance, focus, and physical stamina.
What makes bromantane especially interesting, though, is how different it feels from conventional stimulants. Rather than simply forcing stimulation, it tends to produce a steadier and more functional sense of drive. It has quickly become one of my personal favorites.
>Reduced anhedonia and fatigue. It can make effort feel more worthwhile and rewarding without feeling artificially stimulated.
> Better sleep quality and reduced anxiety. Despite primarily acting like a stimulant, Bromantane can feel surprisingly calming and seems to support a more resilient stress response.
> No obvious comedown. It rarely feels overly stimulating, erratic, or jittery. The effects are exceptionally smooth.
>Strongly dopaminergic. Bromantane increases the expression of enzymes involved in Dopamine synthesis. Creating gradual improvements in mood and mental energy.
>Synergy with other stimulants. Pairing particularly well with amphetamines. It seems to enhance the productive and motivational effects while softening some negatives such as anxiety, overstimulation, or rapid drug tolerance.
You can get 10% off your order with promo code 5HTSKEPTIC at:
eliteresearchusa.com
Modernized rendition of @anabology’s Honey Diet™
Although many theories seek to explain pattern baldness, one observation stays broadly consistent: hair loss tends to occur in scalp regions characterized by high 5αr activity and low aromatase expression.
Given the inverse relationship, It’s understandable why someone might conclude that androgens cause hair loss or that estrogens promote hair growth. But, both claims lack important context. Leaving us with an incomplete framework of what drives hair loss.
Hanz is on the right path, but his model misses one important distinction: Estrogen receptor alpha (ERα) and Estrogen receptor beta (ERβ) are not interchangeable.
Estrogen signaling in the follicle is receptor-specific. ERβ is the receptor worth preserving in this context. It helps suppress the inflammatory, fibrotic, and oxidative programs that drive follicular dysfunction. While excessive ERα activity is more likely to push the follicle toward premature regression.
ERβ knockout mice develop regression significantly faster and exhibit increased apoptotic degeneration, especially in hair follicle keratinocytes. ERβ is best viewed as a catagen modulator —helping reverse the follicle regressing effects of ERα. In other words, ERβ is needed to “buffer” ERα driven regression.
The same receptor pattern appears in female physiology. Higher ERβ activity around ovulation correlates with a more favorable anagen-to-telogen ratio and greater follicle shaft diameter; the decline in ERβ after menopause and postpartum is associated with increased shedding. ERβ loss produces impaired ovulation/subfertility in rodents. Reinforcing that this is more than just a difference in receptor staining.
ERβ also does not rely on aromatization at all. DHT can be locally converted to 3β-diol, which functions primarily as an ERβ-active steroid. 3β-diol accounts for as much as 50% of identified local metabolites in the human scalp. This is functionally relevant because it suggests that an ERβ-biased environment can still be supported without relying on elevated circulating E2.
So, I do not think the correct approach is to deliberately increase estrogen exposure in pursuit of reversing hair loss. The more relevant concept is maintaining regular hormonal turnover, robust 5αr expression, and downstream metabolic handling of the protective ERβ-active steroids.
Male-pattern baldness is likely driven primarily by low estrogen, not high DHT.
Analyzing the distribution of 5AR and aromatase in the human scalp in both men and women reveals important patterns that support this thesis.
In men, frontal follicles expressed high 5AR and low aromatase. Occipital follicles expressed low 5AR and higher aromatase.
Testosterone is converted to DHT via 5AR and to E2 via aromatase. Higher 5AR activity leaves less testosterone available for conversion to E2, skewing the ratio toward higher DHT and lower E2 when 5AR is elevated and aromatase is reduced.
Hair loss in male-pattern baldness occurs in regions with low aromatase expression — that’s why older men often show a U-shaped hair pattern. Regions with higher aromatase expression preserve hair better.
Given the inverse relationship between 5AR and aromatase in the male scalp, hair loss in women helps clarify the driver. Women’s frontal follicles expressed 6x higher aromatase and 3x lower 5AR. Women generally experience far less hair loss than men, except post-pregnancy and during menopause when E2 crashes.
Thus, hair loss is mostly due to the loss of estrogen’s protective effect at the follicle, not directly driven by DHT — otherwise women would not lose hair with low E2. For reference, finasteride increases E2 by ~15% as a side effect.
Low E2 is a main driver of hair loss in men and women. Hair loss is common in bodybuilding, likely due to overzealous use of aromatase inhibitors from fear of E2 excess or use of compounds that block ERα (“DHT derivatives” 🙄)
serotoninskeptic retweeted
You're right and I was afraid of this comment when I made the post, but decided to keep the wording anyway. I'm a bodybuilder turned metabolic health researcher. 3-4 years ago I discovered the work of Ray Peat while researching metabolism for bodybuilding reasons. From there I was hooked - learning and researching health and biology. The things I share on X are just things I'm researching, or into myself. I could talk a lot about bodybuilding, but I'm not really excited about that. I'm excited about biology.
TLDR: Still learning...
Anyone with an intuitive sense of what it means to be “alive” can grasp the principles of bioenergetics and recognize the validity of Ray Peat’s ideas.
By fostering an environment that restores youthful metabolism, you actively shift towards a higher-energy living state.
“Organisms that possess life, are active, functioning, and not dead. A living being demonstrates biological traits such as growth, metabolism, and the ability to respond to stimuli.”
"The ability of unlimited proliferation is an attribute of life. In the simplest living forms, growth is limited only by environmental factors.”
Most people avoid eating too much fruit because of the sugar, I avoid eating too much fruit because of the fiber.
We are not the same.
serotoninskeptic retweeted
many in our space oversimplify getting NIR from the sun
what many miss is that NIR and UV work in opposite ways due to nitric oxide’s effects on the mitochondrion’s electron transport chain
SUNRISE AND SUNSET *before* getting it with UV
or chroma ironforge
… peptaura..? MB-0.2? word salad
tldr: DHT is RECRUITED by the scalp to address the inflammation caused by mitochondrial dysfunction which in turn creates fibrotic tissue that is calcified and lower bloodflow
the dysfunction itself is caused by a gazillion different things, including MCAS, deficiencies, and more
main one's NIR deficiency
sunrise. sunset. vital.
serotoninskeptic retweeted
I’ve been curious about this:
Protein (in theory) is the least likely to be partitioned as body fat. But it’s a very inefficient energy source.
i.e. Seems to have a metabolic slowing effect
Carbohydrates may be more capable of being partitioned as bodyfat. But they are a highly efficient energy source.
i.e. Seems to have a metabolic accelerating effect
Assuming both scenarios involve minimal dietary fat intake. Which macronutrient would keep you leaner in a caloric surplus / overfeeding?
serotoninskeptic retweeted
Your body is really good at storing dietary fat as bodyfat.
Your body is really bad at storing dietary carbohydrates as bodyfat.
Your body is really really bad at storing dietary protein as bodyfat.
The EDtwt community has discovered Peating
But im fairly certain this is NOT what Ray Peat had in mind when he recommended the carrot salad and Coca cola.
