Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 retweeted
Just out - our report on selected M2+-free RNA-cleaving DNAzymes with only amines/guanidines (no imidazoles)...en route to realizing the catalytic promise that ribozymes were supposed to deliver. doi.org/10.1002/cbic.2021006…, @chembiochem, @DNA, @UBCChem
Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 retweeted
🔥 New advance article for RSC Chemical Biology! 🔥 @perrinlab, @APryyma et al @UBCChem on the development of three novel #somatostatin receptor-targeting #peptide #drug conjugates 👏 #chembio
🧐Read the #openaccess article 👉 ow.ly/73s350GxxUA
Very proud and couldn't be more excited to see my research on #Amanitin-based #bioconjugates targeted to pancreatic cancer published in @rsc_chembio . Thank you to all of the authors for their contribution! pubs.rsc.org/en/content/arti…
@perrinlab @bccancerfdn @UBCChem @BioconjChem
A start for targeting amanitin to pancreatic cancer. Alla Pryyma masterfully linked a fully synthetic amatoxin to a peptide for targeted cytotoxicity just out at RSC Chemical Biology: pubs.rsc.org/en/content/arti…
#amanitin, @UBCChem, @CCSResearch, @PanCAN, @rsc_chembio
Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 retweeted
Have you read 'Synthesis and evaluation of “Ama-Flash”, a photocaged amatoxin prodrug for light-activated RNA Pol II inhibition and cell death'? It's the newest Communication from David Perrin @PerrinLab & first author, Kaveh Matinkhoo @UBCChem ⬇ rsc.li/2YU8WiG
Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 retweeted
It's now a matter of "light and death"; pleased that our work on "Ama-Flash" - the first photoactivatable amatoxin - is just out as a preprint at ChemComm: a new tool for chemical biologists to study cell death. pubs.rsc.org/en/content/arti… #amanitin @UBCChem @RoySocChem
Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 retweeted
Beautiful work on new synthetic amatoxins from the Sussmuth lab. doi.org/10.1021/jacs.1c06565. Linking these to linkers via the DHIle or hydoxytryptathionine or Asn to generate ADCs will be the next step to see how they perform as targeted therapeutics. #amanitin
Honored to receive a Best Poster award at the 1st Canadian Peptide and Protein Community Symposium.
Congratulations to my fellow award winners and thank you @CanadianPeptide for a chance to share my PhD research!
Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 retweeted
Taking a poll: which is better - the science or the art? Whatever your answer, we're honored that Antonio's artwork was chosen for the cover of CEJ at: chemistry-europe.onlinelibra…
Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 retweeted
Hope for metastatic prostate cancer patients and a testament to efforts in bioorganic chemistry, molecular imaging, and nuclear medicine: Last week, Novartis wins FDA approval for PSMA-617 - dramatic effects targeted radiotherapy visualized here with PET: eurekalert.org/multimedia/pu…
Alla_Pryyma 🇺🇦 🇺🇦 🇺🇦 retweeted
Xenobiotic (life-like but not living) catalysts can be used to detect super-femto-nano-nothing amounts of Sars-Cov-2 genomic RNA for rapid detection - wow! pubs.acs.org/doi/abs/10.1021…
When is the CIHR going to start funding this type of platform technology? Nice job Chaput Lab.
