Evolution of antibiotic resistance. Ramón y Cajal Fellow at @UAM_Madrid. https://xitter.cf/t.co/cilTGw9jcD
Madrid, Spain
Joined June 2011
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If you like plasmids, insertion sequences, and bacterial evolution, you'll like this one! Now published in its fancy journal format.
Thanks to everyone involved in the project, especially @SastreDJorge, @AlvSanMillan and the funders @BecariosFLC.
nature.com/articles/s41559-0…
Alfonso Santos-López retweeted
Las vacas y el árbol milagro de los incendios de Tres Cantos: la historia tras la foto viral elpais.com/espana/madrid/202… vía @el_pais
Habreis visto esta foto de las vacas de mi padre en muchos sitios con diferentes historias y mucha especulación -como en el tuit que cito-. Os cuento como se produjo este milagro en este artículo: elpais.com/espana/madrid/202…
La importanciade que lso animales pastoreen y limpien el terreno… la naturaleza y los bomberos ayudaron a este pequeño milagro en el #incendio de los tres cantos #trescantos #incendiotrescantos #Incendioforestal
Our latest manuscript is out!
Conjugative plasmids fuel AMR through IS-mediated gene inactivation, promoting the evolution of multidrug resistance in bacteria.
Hope you like it
New paper out! 📣📣
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experiments and bioinformatics, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
biorxiv.org/content/10.1101/…
Alfonso Santos-López retweeted
Excited to share our latest collab with Wenyuan Han's Lab! 🚨 Bacteria use dITP as an immune signal to activate NAD+-depleting effectors. Phages counter immunity by destroying dAMP (dITP precursor)! 💥🧬
Preprint 🔗: biorxiv.org/content/10.1101/…
Alfonso Santos-López retweeted
Should I stay or should I go? 🎶
In a new opinion piece, @c_igler, Andrina Bernhard and I discuss how conjugative plasmids and temperate bacteriophages balance vertical and horizontal transmission: ecoevorxiv.org/repository/vi…
Our framework illuminates many sides of MGE biology (1/7)
Alfonso Santos-López retweeted
Happy to announce we have been awarded an i-LINK grant to create a new obligate intracellular bacteria consortium with 3 top labs @MattWelchLab @lamasonlab @bonazzilab. I can´t wait to start exploring new science with you all. See you soon at the @CNB_CSIC
Alfonso Santos-López retweeted
Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵 science.org/doi/10.1126/scie…
Alfonso Santos-López retweeted
New paper from the lab. The brilliant @norapyenson led a multi-lab collaboration to investigate the consistent formation of stable phage communities infecting a single clonal host population. She explains the gist of it beautifully in the quoted thread. Congrats Nora et al
Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵 science.org/doi/10.1126/scie…
Alfonso Santos-López retweeted
🚨New preprint!! How do antibiotic-resistant bacteria grow in the human gut microbiome, even without antibiotics? 🤔 We reveal strain-specific ecological interactions that shape their growth within microbial communities. 🧵👇 1/5 biorxiv.org/content/10.1101/…
Alfonso Santos-López retweeted
» Gene acquisition by giant transposons primes eukaryotes for rapid evolution via horizontal gene transfer | Science Advances science.org/doi/full/10.1126…
Alfonso Santos-López retweeted
Las seis universidades públicas madrileñas han aprobado una Carta Abierta y un Comunicado para reclamar a la @ComunidadMadrid una financiación suficiente en los Presupuestos de 2025 en defensa del servicio público que prestan.
uam.es #defendamoslaUniversidadPública
@unicomplutense @uc3m @urjc @UAHes @La_UPM
Alfonso Santos-López retweeted
Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @implosian, @baym, @nquinoneso, Kesther and Carmen! biorxiv.org/content/10.1101/… 1/
Awesome! Huge thanks to @evokerr, @livkosterlitz and Elisabeth Duan for this fantastic Spotlight on our recently published paper (nature.com/articles/s41559-0…).
New: Elizabeth Duan, Olivia Kosterlitz (@livkosterlitz) & Benjamin Kerr (@evokerr) spotlight the @NatureEcoEvo article by Alfonso Santos-Lopez (@ASantosLopez), Alvaro San Millan (@AlvSanMillan) & team on mobile elements as agents of rapid adaptive change.
tinyurl.com/2u25mynh
Alfonso Santos-López retweeted
Jose Luis Martinez—not active in social media ☹️—a legend of Spanish Microbiology will retire soon. His friends & colleagues will hold in Nov 28 a warm homage of a lifelong dedication to Microbiology & his many contributions to Ecology and Evolution of antibiotic resistance 👏
Alfonso Santos-López retweeted
It is out @CurrentBiology ! we show that when learnt together conflicting experiences formed co-existing memories that compite to drive behavior & that ➕ valence of a stimulus is encoded differently in the 🧠 depending on its meaning.
Alfonso Santos-López retweeted
For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmids from any bacterial species.
We are thrilled to see this work now published in @NatureMicrobiol after thorough peer review!
nature.com/articles/s41564-0…
Alfonso Santos-López retweeted
🧬🧬 𝙉𝙚𝙬 𝙋𝙧𝙚𝙥𝙧𝙞𝙣𝙩!!🧬🧬 Latest collab with the amazing Ming Li & Yue Feng labs!
How do phages bypass multi-layered defenses in bacteria? Spoiler: with equally complex anti-defenses!! 🧵👇 biorxiv.org/content/10.1101/…
Alfonso Santos-López retweeted
Extremely happy to see the final version of our paper "The expression of integron arrays is shaped
by the translation rate of cassettes" out in @NatureComms 🥳!!! Thanks to the reviewers for their valuable feedback and suggestions!
rdcu.be/dX8BB
Alfonso Santos-López retweeted
Orgulloso y feliz de recibir el Premio de Investigación Margarita Salas de la CAM.
Es el segundo premio en dos semanas ¡un verdadero reconocimiento al trabajo que hacemos en el labo!
Gracias a mis mentores, compañeros y colaboradores ¡este premio es de todos!
¡Seguimos! 🍾🥂🎉
🔬 La @comunidadmadrid ha concedido los Premios de Investigación Margarita Salas, Miguel Catalán y Julián Marías 2024, que reconocen las trayectorias profesionales de los investigadores de la región
📚 La relación de ganadores se ha publicado en el BOCM
c.madrid/1ztu31
Alfonso Santos-López retweeted
Merecedísimo premio a @Jero_RB. Alegría inmensa para los que disfrutamos tu saber y compañia. Tb para la microbiología española, comunidad de excelentes investigadores con aportaciones esenciales a la ciencia global durante décadas @SEMicrobiologia @SEIMC_ @ciberinfec @microRyC
✅ El Ministerio de @CienciaGob concede los Premios Nacionales de Investigación 2024.
🗣️@DianaMorantR: "Son el reconocimiento más importante de España en el ámbito de la investigación científica y es la edición con mayor número de mujeres premiadas".
👉🏻ciencia.gob.es/Noticias/2024…
