@AdrianWoolfson

Author: The Future of Species: @BloomsburyPub @mitpress. Life Without Genes @HarperCollins. Opinions @WSJ @Sciencemagazine Founder & CEO https://xitter.cf/t.co/8YmyWwW4vX

 San Francisco, CA
adrianwoolfson.com
Joined October 2011
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science.org/content/article/…

This odd fish has 30 times as much DNA as humans—a new record for animals

Lacking key genes that control selfish bits of DNA, the South American lungfish’s genome just grew and grew

science.org
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nature.com/articles/s41587-0…

Genetic code expansion enables plant-directed control of bacterial activity

Nature Biotechnology - The noncanonical amino acid O-methyl-L-tyrosine is used as a tool to control microbial protein synthesis across diverse plants.

nature.com
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anthropic.com/research/forma…

LLMs are making formal software verification feasible at a much larger scale

Claude formally proved security properties in the compiled code of 123 open-source libraries. Along the way, it found bugs that had eluded detection for years.

anthropic.com
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share.google/7hCB3sUkUXnFmAe…

Tiny Genetic Tweak From An Ancient Virus Might've Prevented Chimpanzees From Developing Brains Like...

Did a virus help split the evolutionary paths of humans and chimpanzees?

sciencealert.com
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nature.com/articles/s41586-0…

Programmable design of functional proteins from natural language

Nature - Pinal, a 16-billion-parameter artificial intelligence model, designs functional proteins from natural-language descriptions, demonstrating experimentally validated activities and improved...

nature.com
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pnas.org/doi/10.1073/pnas.11…,

Regeneration of whole fertile plants from 30,000-y-old fruit tissue buried in Siberian permafrost |...

Whole, fertile plants of Silene stenophylla Ledeb. (Caryophyllaceae) have been uniquely regenerated from maternal, immature fruit tissue of Late Pl...

pnas.org
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geekwire.com/2026/uw-protein…

UW protein institute led by Nobel winner unveils its first AI model co-developed with Nvidia

UW’s Institute for Protein Design and Nvidia have released their first jointly developed AI model for creating proteins with specific jobs. The release follows a computing grant from Nvidia CEO...

geekwire.com
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indianexpress.com/article/up…

How AI could open new avenues in biological research

An AI system recently helped identify a previously unknown enzyme system inside viruses that infect bacteria. What does the finding reveal about the growing role of AI in biology? How could this...

indianexpress.com
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<a href="">xitter.cf/nature/status/21133557…</a> xitter.cf/nature/status/21133557…
nature
@NatureOct 22
A powerful gene-editing technique has been used to edit DNA directly in a person’s body — the first known instance of such a treatment. go.nature.com/4Bgi3Yx

A first for CRISPR: powerful prime editing alters DNA directly in the human body

Nature - Application of the high-precision technique is part of a clinical trial to treat a genetic disease that can cause liver and nerve damage.

nature.com
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Why AI isn’t ready to tackle our convoluted genomes. A new article in @WIRED that mentions Genyro and my concept of ‘the informiome’ as detailed in my book On the Future of Species. share.google/Af7ucfpTyVp2Hsc…

Why AI Isn’t Ready to Tackle Our Convoluted Genomes

The DNA inside our cells isn’t just a series of instructions, but something far more dynamic. Like scientists, AI models don't yet have the data to properly decode it.

wired.com
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nature.com/articles/s41586-0…

De novo design of enantioselective artificial metalloenzyme photocatalysts

Nature - De novo design of enantioselective artificial metalloenzyme photocatalysts

nature.com
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pnas.org/doi/10.1073/pnas.17…

Three-dimensional visualization and a deep-learning model reveal complex fungal parasite networks...

Some microbes possess the ability to adaptively manipulate host behavior. To better understand how such microbial parasites control animal behavior...

pnas.org
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A parasitic fungus that turns ants into zombies. link.springer.com/article/10…

Behavioral mechanisms and morphological symptoms of zombie ants dying from fungal infection

BMC Ecology - Parasites that manipulate host behavior can provide prominent examples of extended phenotypes: parasite genomes controlling host behavior. Here we focus on one of the most dramatic...

link.springer.com
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washingtonpost.com/opinions/…

Opinion | AI capabilities mean America needs a Manhattan Project for biodefense

Uncertainty about potential harm from AI is no reason to postpone preparedness.

washingtonpost.com
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Designed synthetic minimal CRISPR editing systems science.org/doi/10.1126/scie…

Structure and evolution-guided design of minimal RNA-guided nucleases

The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic...

science.org
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ox.ac.uk/news/pulse/health-m…

Tracing viral evolution through DNA

Some of the most intriguing fossils in Earth’s history are impossible to see by eye. Buried in our genome, tens of thousands of ‘viral relics’ chart an evolutionary arms race almost as old as life...

ox.ac.uk
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rolandoperezphd.substack.com…
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science.org/content/article/…

Exclusive: An AI agent emailed hundreds of researchers for help. It told us why

To get to the bottom of this perplexing behavior, Science interviewed the agent

science.org
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Great to see Genyro featured in today’s edition of @TheEconomist #SynBio #AI #AIxBio #Evolution #SyntheticBiology
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qbi.ucsf.edu/qbi-highlights/…

QBI - Squids Edit RNA for Novel Protein Functions

qbi.ucsf.edu
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