PhD in Biochemistry at @usponline; Postdoc at @UCBerkeley ☀️
Berkeley, CA
Joined April 2022
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Alex Inague retweeted
1/ Happy to see this collaborative work w/ Fangzhu Zhao, @realJimWells & colleagues now published in @PNASNews!
LRP8-targeted KineTACs degrade LRP8, reduce GPX4 & other selenoproteins, and sensitize cancer cells to ferroptosis.
pnas.org/doi/10.1073/pnas.26…
Alex Inague retweeted
New preprint! We find that fatty acid double-bond geometry alters their metabolic fate and ferroptosis sensitivity. Trans fatty acids are metabolized differently from their cis counterparts, reshaping membrane phospholipids and ferroptosis sensitivity.
biorxiv.org/content/10.64898…
Alex Inague retweeted
Happy to have contributed to this preprint with Fangzhu Zhao and @realJimWells! LRP8-targeted bispecific antibody degraders degrade the selenium uptake receptor LRP8, reduce GPX4 / selenoproteins, and sensitize cancer cells to ferroptosis.
biorxiv.org/content/10.64898…
Alex Inague retweeted
Vitória brasileira: Fruto do esforço científico nacional, a Butantan-DV começou a ser desenvolvida em 2009, quando o Brasil enfrentava recordes de dengue. Foram 270 experimentos e 50 tentativas de formulação até chegar ao produto final. Saiba mais: tinyurl.com/mrx8ah2k
Alex Inague retweeted
Proud for being launching our Center of Metabolism at USP!!! Together with my colleagues @AJKowaltowski
@sayuri_miyamoto e Marilia Seelander we are creating CoMeta. Take a look below to know more about this: jornal.usp.br/uspnews/new-us…
Alex Inague retweeted
Excited to share our new study out in @NatureCellBio! Led by postdoc @MikeLangePhD, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
nature.com/articles/s41556-0…
Alex Inague retweeted
An absolute privilege and joy to work with this exceptional group of scientists at @UCBerkeley. ☺️#NewLabPhoto
Alex Inague retweeted
Happy to have contributed in a small way to this exciting story from Fangzhu Zhao and @realJimWells now out in @J_A_C_S.
"Hijacking Extracellular Targeted Protein Degrader–Drug Conjugates for Enhanced Drug Delivery"
pubs.acs.org/doi/10.1021/jac…
Alex Inague retweeted
Congratulations to @BerkeleyMetBio professor @apsarruda and postdoc @AlexInague, who each received multiyear grants from @pewtrusts to support their research and professional growth. Read more: linkedin.com/pulse/two-nst-r…
Alex Inague retweeted
🎉Congrats to our 2025 biomedical scholars and fellows!
These 37 early-career scientists are embarking on innovative research projects in neuroscience, microbiology, cancer research, and more. pewtrsts.org/4mg4l01
Alex Inague retweeted
My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s41586-0…
Alex Inague retweeted
Exciting new work from @looogannn & Scott Dixon in @nchembio! Tegavivint, a clinical-stage drug, triggers a novel lipid-dependent nonapoptotic cell death via TECR and palmitate synthesis. Very cool! 🤩
nature.com/articles/s41589-0…
Alex Inague retweeted
Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome!
📅 Abstract deadline: June 1, 2025.
shorturl.at/QA6T1
Alex Inague retweeted
Excited to share our new preprint! Exceptional work by postdoc @MikeLange identifies the first #LipidDroplet lipid quality control pathway! Droplet-localized FSP1 safeguards stored neutral lipids, blocking their peroxidation & #ferroptosis induction.🤩biorxiv.org/content/10.1101/…
Alex Inague retweeted
New paper is out!🎄🥳
Identification of Novel Human 15-Lipoxygenase-2 (h15-LOX-2) Inhibitors Using a Virtual Screening Approach.
Congratulations to all authors! @lucasgviv, Thais Iijima, Erika Piccirllo, Leandro Rezende, Thiago Alegria, Luis Neto +
pubs.acs.org/doi/10.1021/acs… – at Sao Paulo, Brazil
Alex Inague retweeted
Immunologist Dr. Gabriel D. Victora shares how he changed career paths from classical pianist to immunologist and discusses the importance of not letting technological limitations get in the way. #50ScientistsThatInspire #CP50
Read the full interview:
cell.com/news-do/50-inspirin…
ALT Quote by Dr. Gabriel D. Victora: "Never let the availability of technologies lead the way. If there is something you would really like to study but can’t, then come up with a way."
Alex Inague retweeted
Grateful to @berkeleyMCB for highlighting our lab and our recent discoveries! It was fun to discuss some of the surprises during our research on lipid homeostasis, lipid droplets, & ferroptosis—driven by exceptional UC Berkeley students & postdocs. mcb.berkeley.edu/news-and-ev…
Alex Inague retweeted
Online Now: PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance dlvr.it/TGB651
Alex Inague retweeted
Our Molecular Therapeutics department @UCBerkeley is looking for a Metabolomics Specialist! If you're skilled in untargeted and targeted metabolomics applications and want to contribute to the discovery of novel biology and drugs then this is for you! aprecruit.berkeley.edu/JPF04…
Alex Inague retweeted
Please RT and help us get the word out. Scott Dixon @sjd956 and I are co-organizing the first @FASEBorg #Ferroptosis conference this summer! Awesome line up of speakers and room for additional short talks! Save the date & come join us July 27 - 31, 2025! 🤩events.faseb.org/event/11797…
ALT FASEB Ferroptosis Conference!