@AlgulLab

Gastrointestinal Cancer and Inflammatory Research Comprehensive Cancer Center München Klinikum rechts der Isar Technische Universität München

 Munich, Germany
cccm-mri-tum-de.dev-muc.de/de/lehrstuhl-fuer-tumormetabolismus
Joined April 2021
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  • Following332
  • Followers296
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Finally out! 🧿 🧿 🧿 Working on the revision while being on maternity leave was… an experience 😅Between sleep deprivation and newborn life, I’m fairly sure I had only a few neurons left alive — but somehow, we made it. link.springer.com/article/10…

c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation...

Molecular Cancer - Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with limited treatment options and a high recurrence rate. Recurrence often occurs with...

link.springer.com
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We are looking forward to welcoming Dr. David Herrmann from @Timpson_Lab (@GarvanInstitute) to speak at our institute! He will share his recent work on targeting pancreatic cancer invasion and metastasis. July 7, 5pm - looking forward to his insights!
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Tour de force pancreas cancer study in @nature by @Aiims1742 (Anirban Maitra) @MDAndersonNews, revealing profound transcriptomic heterogeneity & TME dynamics in metastases. Interesting CAF dynamics associated with cell state changes -- super cool. doi.org/10.1038/s41586-025-0…

Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer

Nature - Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the...

nature.com
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"Algül Lab proudly presents… 🥁 The long-overlooked child of NF-κB signaling in solid tumors: c-Rel! Our latest study shows how this underdog drives PDAC metastasis by helping cancer cells survive isolation stress. Curious about how? Sneak a peek here: doi.org/10.1101/2025.01.29.6…
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Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer | Nature nature.com/articles/s41586-0…

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer

Nature - Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

nature.com
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Timescales in Cell Biology
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Checkout new paper from our lab in @NatureGenet link: nature.com/articles/s41588-0… We mapped pancreatic cancer ecosystems across primary tumors and metastases using spatial transcriptomics on matched samples . @2AteeqKhaliq @BasselElRayesMD @IUCancerCenter
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Algül Lab is hiring a new postdoctoral researcher! If you are excited to work in the pancreatic cancer field under the funded BMBF consortium, we are looking forward to seeing your applications! Please spread the word!😊#pancreaticcancer #postdoc eacr.org/job/postdoctoral-fe…
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Tgfa-Ccl2-paxillin axis driving human-like neural invasion! This great study is finally out @jclinicalinvest! Many congratulations to first author Xiaobo and the team of Prof. Demir, one of the pioneers in cancer neuroscience,@PancNeuropathy, and Dr. Lesina from our @AlgulLab!
DEMIR Lab@PancNeuropathy23 Aug 2023
Proud to share our latest work in @jclinicalinvest jci.org/articles/view/166333✅ Tremendous effort by our lab members with Xiabo Wang and key contributions by @AlgulLab as well as great work by @gastrotum @labreichert & more! #PancreaticCancer #CancerResearch #Cancer #Demirlab
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Proud to share our latest work in @jclinicalinvest jci.org/articles/view/166333✅ Tremendous effort by our lab members with Xiabo Wang and key contributions by @AlgulLab as well as great work by @gastrotum @labreichert & more! #PancreaticCancer #CancerResearch #Cancer #Demirlab
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Great honor to meet with Prof. Capecchi in person, nobel laureate 2007. His work made it possible to engineer mice genetically to model diseases, including pancreatic cancer as we study it. #science #lino2023 #sciencecelebrity
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🌟Thrilled and grateful as the Algül Lab, which has 2 (@Delllliyyyya & @kivancgorgulu) distinguished scientists for the prestigious #LINO2023 Lindau Nobel Laureate Meeting this week🔬🔥 @lindaunobel @TU_Muenchen #AcademicTwitter
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Being selected for this remarkable gathering of brilliant minds is an extraordinary honor. Our outstandingscientists can't wait to exchange ideas, forge collaborations, and ignite scientific breakthroughs!
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Together, let's shape a brighter future through innovative research and transformative discoveries! 🌍💡 #NobelLaureates #ScienceCommunity
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Great to present our progress on SHERPA trial with @BernardsLabora1 at @cancer_carmona with wonderful and thoughtful remarks of the Nobel laureate Phil Sharp. So grateful to @cancer_carmona wonderful meeting with giants in the field of cancer
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Remarkable talk given by Robert Winn on cancer health equity in lung cancer. Very important topic, good luck and keep going. Very relevant! Good luck!!! In a nutshell: ZNA vs DNA!! Thanks to @SU2Cscience for supporting such projects
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Wonderful meeting/discussions with our friends from twitterless Marc Nazare and his team in Berlin @LeibnizFMP. Thanks to ⁦@dfg_public⁩ great joint effort and progress on generation of new class SHP2 inhibitors. ⁦@AlgulLab⁩ learnt a lot about medicinal chemistry. 👌
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The paper offers a wonderful tool to study NF-kB, without genetic silencing or overexpression of the transcription factors. Amazing work! Double knockin mice show NF-κB trajectories in immune signaling and aging cell.com/cell-reports/fullte…

Double knockin mice show NF-κB trajectories in immune signaling and aging

Rahman et al. present fluorescent knockin mice that track one or both of the canonical subunits of NF-κB. The power of these reporters is illustrated with several approaches that gain deeper insights...

cell.com
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The study is a follow up work from our previous publication based on @dietrichruess and @schiselinski `s wonderful work. You can find the great load of mind blowing data, proving the importance of SHP2 in KRAS dependent cancers in the publication: nature.com/articles/s41591-0…
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