Ash

Nicki, I’ve got the U-Haul ready. It’s time to fire the worst governor in America.

How to lower excess estrogen: - Cut alcohol (it switches on aromatase, the enzyme that turns testosterone into estrogen, and it slows the liver's clearance of estrogen. In one study a single drink raised estradiol in women on HRT 3x within an hour, PMID 8940324) - Get body fat under 25% (fat tissue makes its own estrogen through aromatase. A year of diet-driven weight loss cut estradiol 16% and free estradiol 21%, PMID 22614972) - Cut the xenoestrogens you touch every day (plastic food containers, fragranced products, non-stick pans, unfiltered tap water, polyester against sweating skin) - Sunlight, egg yolks and oysters (vitamin D, vitamin E and zinc all turn aromatase down. Active vitamin D cut aromatase expression in fat and breast tissue, PMID 19906814) - 150mg DIM twice a day (pushes estrogen breakdown toward the weak 2-OH form instead of the potent 16-OH form, and raised SHBG in a 12-month placebo-controlled trial, PMID 28560655) - Feed the liver's exit routes: choline from 2 to 3 egg yolks a day, 3g glycine, 100 to 200mg magnesium taurate with dinner (methylation and COMT are how the liver tags estrogen for disposal, and they run on choline, glycine and magnesium) - 200mg calcium D-glucarate with lunch (blocks the gut enzyme that unwraps estrogen the liver already packaged for exit) - 30g of fiber a day plus 1 raw carrot between meals (going from 15g to 30g of fiber dropped estrone and estradiol in 2 months in 62 women, PMID 1652197)

The inflammation lowering stack I use when I see homocysteine above 7.2 and hsCRP above 1: - 500mg Longvida curcumin (shuts off NF-kB, the master inflammation switch) - 500mg quercetin phytosome (calms mast cells) - 1 tsp black seed oil with a meal (thymoquinone, the strongest anti-inflammatory in a kitchen) - 3g fish oil (crowds arachidonic acid off the enzyme that makes inflammatory prostaglandins) - 600mg NAC (refills glutathione, which inflammation drains first) - 3g glycine (the other half of glutathione, and feeds methylation) - methylated B complex (the B6 and folate that clear homocysteine) - 400mg magnesium glycinate at night Inflammation shuts methylation down. Oxidative stress switches off the enzyme that recycles homocysteine and burns through the B6 that clears it (PMID 11401933). Push methyl donors alone and homocysteine barely moves. Lower the inflammation and the methylation comes back on its own.

Delusion fuels success

I’m asking New York to get vocal against Hochul — peacefully. Vote Bruce Blakeman.

THYROID HEALTH and SIBO are deeply intertwined If you have SIBO, your thyroid is involved. If you have hypothyroidism, your gut is involved. Here's how they're connected: Absorption Your thyroid needs certain nutrients to produce hormone and convert T4 (the inactive form) to T3 (the active form). Selenium: required for the enzymes that convert T4 to T3 Zinc: needed for TSH production and T4 to T3 conversion Iron: required for the enzyme that actually makes thyroid hormone Tyrosine: the amino acid needed thyroid hormone itself Iodine: the raw material for T4 and T3 When the gut is inflamed, overgrown, or damaged (leaky gut, SIBO, H. pylori, parasites, low stomach acid), absorption of these nutrients is much lower. T4 to T3 Conversion About 20% of T4 is converted to T3 in the gut, specifically by healthy gut bacteria. When the microbiome is disrupted, that conversion drops. This is why people on T4-only medication (Levothyroxine, Synthroid) can still feel terrible despite normal TSH. Their gut isn't converting it properly, so they have plenty of inactive hormone and not enough active hormone. Inflammation Gut inflammation causes systemic inflammation. Inflammation directly suppress thyroid function in multiple ways: -They reduce TSH output from the pituitary -They block T4 to T3 conversion -They increase reverse T3 (the inactive form of T3) -They reduce thyroid hormone receptor sensitivity at the cell level So even if you're producing thyroid hormone, you can't use it properly when gut inflammation is high. Now getting into how thyroid affects gut health: Slowed Motility Your small intestine has a cleansing wave called the migrating motor complex (MMC). It sweeps through every 90 to 120 minutes between meals, pushing bacteria and leftover food debris down and out of the small intestine. Thyroid hormone is needed for this to work effectively. When thyroid is low, the MMC slows down. Instead of bacteria being swept out, they continue to colonize. Studies have shown hypothyroid patients have significantly higher rates of SIBO than the general population. Slow motility allows: -Fungal overgrowth, usually Candida -Methane overgrowth (archaea, which cause constipation-dominant SIBO) -Parasites -H. pylori Low Stomach Acid Thyroid hormone is required for the stomach to produce hydrochloric acid. Stomach acid is your first line of defense against pathogens. When food comes in, HCl is supposed to kill the bacteria, fungus and parasites. When stomach acid is low: -Bacteria and fungi pass through alive and colonize further down -Food doesn't break down properly, leaving undigested material that feeds overgrowths -Protein digestion fails, which later starves the gut lining of repair materials -The signal to release pancreatic enzymes and bile goes down This is a huge cause of overgrowths. Reduced Bile Flow Bile is antimicrobial and helps keep the small intestine clean. Thyroid hormone affects bile production in the liver and gallbladder motility. Sluggish bile means: -Less antimicrobial activity in the small intestine -Poor fat digestion (which can cause nutrient deficiencies) -Bile stagnation in the gallbladder -Toxins that should be excreted get recirculated This is why hypothyroid patients have gallbladder issues and why bile support is necessary for good gut protocol. Immune Function in the Gut The gut is the home to the immune system; it produces secretory IgA, which is your defense in the gut. Thyroid hormone is required for proper immune function. Low sIgA means the gut can't defend itself against pathogens, opportunistic bacteria, fungi, and parasites. I see this on my clients labs all the time; low sIgA, multiple overgrowths, and thyroid issues all coming back. Tissue Repair The gut lining turns over every 3 to 5 days. Rapid cell turnover requires energy and raw materials. Thyroid hormone drives metabolic rate. Low thyroid means slower cellular repair everywhere, including the gut lining. So the damage caused by overgrowths heals more slowly, leaky gut persists longer and inflammation stays high. Constipation Low thyroid slows the large intestine too, not just the small intestine. This causes toxins and hormones to get reabsorbed. This creates: -More estrogen recirculation (worsens hormonal issues) -More toxins -A better environment for methane-producing organisms, which slow motility even more To sum it up: When your thyroid is low, your motility slows, your stomach acid drops, your bile gets sluggish, your gut immunity weakens, and your tissue repair slows down. This creates the perfect environment for bacterial, fungal overgrowths to happen. Those overgrowths then cause inflammation, block nutrient absorption, and damage your gut lining. Now your thyroid can't get the nutrients it needs, T4 to T3 conversion fails, and the immune system is compromised. This is why you can't fix one without addressing the other. You can kill the SIBO with a perfect protocol, but if the thyroid is still not functioning well, it can come right back. And you can take thyroid medication, but if the gut is inflamed you won't absorb nutrients or convert hormones. This is another example of how truly healing requires a COMPREHENSIVE and HOLISTIC approach. Isolating and treating individual symptoms rarely ever result in truly healing.

Just mixed my first 12 oz glass I will be drinking one ounce an hour 😜 what interests me too is the whole addition of chewing 1-2 mg nicotine gum along with this if I feel flu coming on? The nicotine blocks the virus 🦠 at receptor sites? Wild!

ApoLactoferrin + S. Boulardi is the best duo to fix SIBO, leaky gut, bloating, gas, and loose stools. it starves pathogens of iron, dissolves biofilms, neutralizes luminal endotoxin (LPS), surges secretory IgA (sIgA), and tightens epithelial junctions to permanently halt loose stools. Here is the cellular science and execution protocol👇 Why Traditional Protocols Fail in SIBO & Loose Stools • The Probiotic Fermentation Trap: In SIBO, bacteria colonize the small intestine. Adding standard bacterial probiotics acts as fertilizer, triggering rapid carbohydrate fermentation, distension, and histamine flares within 30 minutes of eating. • Iron Hoarding & Biofilms: Opportunistic pathogens (Klebsiella, E. coli, Pseudomonas) scavenge free ferric iron (Fe3+) via siderophores to proliferate and construct extracellular polymeric biofilms, shielding them from traditional therapies. • Hyperactive Gastrocolic Reflex: Fermentation gas mechanically stretches the small intestine, firing an aggressive reflex that dumps unabsorbed water and bile into the colon, producing 4 to 6 loose, urgent stools daily. Apolactoferrin: Iron-Starvation & Mucosal Sealing Use Apolactoferrin (iron-depleted, less than 5% iron saturation), not hololactoferrin: • Bacterial Starvation: With iron affinity roughly 300 times higher than transferrin, it strips free luminal Fe3+, starving pathogens of the substrate required to divide and maintain biofilms. • Lactoferricin Lysis: Gastric pepsin cleaves apolactoferrin into Lactoferricin, a positively charged antimicrobial peptide that binds negatively charged LPS on Gram-negative bacteria to trigger osmotic lysis. • LPS Neutralization: Binds the toxic lipid A domain of free luminal endotoxin (LPS), neutralizing it before it can activate enterocyte TLR4/NF-kB inflammatory destruction. • Tight Junction Re-Assembly: Upregulates Zonula Occludens-1 (ZO-1), Occludin, and Claudin-1, sealing paracellular leaks against antigen translocation. Saccharomyces boulardii: The Non-Colonizing Yeast Shield A non-bacterial, antibiotic-resistant probiotic yeast that completely clears within 3 to 5 days of cessation: • 54-kDa Protease Cleavage: Secretes a serine protease that cleaves and deactivates bacterial enterotoxins (e.g., C. difficile, E. coli), shutting down toxin-induced chloride and water dumping. • Surging sIgA Defense: Upregulates polymeric immunoglobulin receptors (pIgR), driving massive luminal secretion of secretory IgA (sIgA) to neutralize antigens. • Brush-Border Restoration: Stimulates intestinal lactase, sucrase, maltase, and Intestinal Alkaline Phosphatase (IAP), which detoxifies endotoxin and eliminates carbohydrate-driven osmotic diarrhea. • Candida Antagonism: Secretes capric acid, halting Candida albicans filamentation and biofilm synthesis. The Synergistic Lock: Halting Loose Stools Fast • Biofilm Breach & Escort: Apolactoferrin dismantles biofilm iron scaffolds, allowing S. boulardii to capture exposed pathogens via surface mannose adhesions and sweep them out in stool. • Stool Consolidation (5–6 Down to 1–2): Blunting inflammatory cytokines while downregulating mucosal cAMP/cGMP halts fluid dumping, shifting stool form from liquid (Bristol 5–7) to formed logs (Bristol 3–4). • Commensal Optimization: Synthesizes short-chain fatty acids (SCFAs like butyrate) to fuel colonocytes without fermenting in the small intestine. The Motility Engine: Cellular T3 Clearing overgrowth fails long-term if your Migrating Motor Complex (MMC) is stalled: • The MMC cleans the small intestine every 90 to 120 minutes during fasting via smooth muscle contractions dependent on active cellular T3 and vagal acetylcholine tone. • Hypothyroidism blunts gastric acid, reduces antimicrobial bile flow, and halts the MMC, allowing bacteria to migrate upward. Restoring metabolic rate and stomach acid is non-negotiable to prevent relapse. Clinical Dosing & Execution Directive • Phase 1: S. boulardii (Days 1–3): 250mg to 500mg (5 to 10 billion CFU) twice daily with warm water, 20 to 30 minutes before your two main meals to prime sIgA and prevent Herxheimer die-off. • Phase 2: Apolactoferrin (Day 4 Onward): 250mg to 500mg once to twice daily on an empty stomach (45 minutes pre-meal or pre-bed) with warm water. • Mandatory Operational Rules: No Cold Liquids With Meals: Avoid drinking cold fluids around food to preserve gastric acid concentration and gut motility. Daily Raw Carrot Salad: Grated washed carrot, 1 tsp coconut oil, 1 tsp apple cider vinegar, and salt taken 2-3 hour post-breakfast to bind and excrete loosened endotoxin. • Timeline: Days 1–5 resolve cramping and urgency; Days 7–14 consolidate bowel movements down to 1–2 solid stools; Days 14–30 clear systemic endotoxemia, resolving brain fog and expanding dietary tolerance.