Fungal natural product, genome mining, biosynthesis, synthetic biology, Tohoku University
Sendai, Japan
Joined February 2023
- Tweets39
- Following21
- Followers129
- Likes28
Asai_lab. retweeted
The Ozaki (A01) and Asai groups have elucidated the biosynthetic pathway of chlorflavonin. Precise control of isomerization between 6- and 8-methoxyflavonoids is key to the biosynthesis of this fungal flavonoid. @J_A_C_S pubs.acs.org/jacsat/article/…
Our new paper is out! We elucidated the complete biosynthetic pathway of chlorflavonin. We uncovered the interplay between 6- and 8-methoxy flavonoids and the basis of substrate selectivity in CfvK. @J_A_C_S
pubs.acs.org/jacsat/article/…
Happy to share our latest paper in Organic Letters (OA)!
We report the biogenesis of fungal polyketide chaetophenols by enzymatic and nonenzymatic reactions. @ACSPublications
pubs.acs.org/orlef7/article/…
Happy to share our latest paper in BBB!
We identified the biosynthetic gene cluster of the potent fungicidal peptide PF1451A and discovered that an IPR053008-family protein is responsible for valine desaturation.
Congrats to Hibi-san!!
academic.oup.com/bbb/article…
Our new paper has been published in Chem. Pharm. Bull. We report the isolation and structural elucidation of a new mollicellin analogue from Chaetomium brasiliense.
Congrats to Sho on his second publication from our lab!
jstage.jst.go.jp/article/cpb…
Happy to share our latest paper in J. Antibiot.!
By genome mining that integrates sequence, domain architecture, and structural modeling, we discovered an unusual fungal gene cluster for dimeric alkylresorcinol biosynthesis. Congrats, Yuto and Tomoya!
nature.com/articles/s41429-0…
Our paper has just been published in Chem. Pham. Bull.! Through heterologous expression, we have discovered new 10- and 12-membered fungal macrolides from a gene cluster in Aspergillus petrakii. Congrats Li-san on his first paper from our lab!
jstage.jst.go.jp/article/cpb…
Asai_lab. retweeted
🟡#研究成果 #プレスリリース
ビニグロールの生合成に関与する新しいタイプのテルペン環化酵素の機能を解明 ―実験と理論の協奏により詳細な反応機構を提唱－
#東北大学 #大学 #SDGs
📗論文はこちら
doi.org/10.1021/jacs.5c14400
🔻ポイントはこちら🔻
tohoku.ac.jp/japanese/2025/1…
Thrilled to share our new JACS paper! We uncovered the unique vinigrol terpene cyclase VigB and its cyclization pathway! We also discovered new routes to diversify its unusual diterpene scaffold! pubs.acs.org/doi/10.1021/jac…
Many thanks to all the presenters and participants for joining the “25th Symposium on the Development and Application of Naturally Occurring Drug Materials” in Sendai! We are pleased to have organized this long-standing symposium!
Our new paper is out @JOC_OL (open access)!
Through genome mining of a fungal endophyte, we discovered new natural products with unique pyrano[2,3‑c]pyrrole scaffolds. Congrats to Seki-san on this 2nd paper from the pdD project!
pubs.acs.org/doi/10.1021/acs…
第25回 天然薬物の開発と応用シンポジウム
発表申込締切を2025年8月1日まで延長しました。
皆様の積極的なご応募をお待ちしております！
tennen2025.wixsite.com/senda…
Asai_lab. retweeted
The Ozaki (A01) group, in collaboration with Prof. Teigo Asai group @Asai__lab, demonstrated that the ketosynthase domain of a highly-reducing polyketide synthase catalyzed β-lactone formation in the biosynthesis of hymeglusin. @J_A_C_S pubs.acs.org/doi/full/10.102…
第25回 天然薬物の開発と応用シンポジウム
10月11日（土）〜12日（日）に東北大学にて開催されます。
現在、発表演題を募集中です。
発表申込締切：7月25日（金）
皆様の積極的なご応募をお待ちしております！
tennen2025.wixsite.com/senda…
Asai_lab. retweeted
🟡#研究成果 #プレスリリース
β-ラクトンの新たな生合成機構を解明 新たな創薬リードの探索に期待
#東北大学 #大学 #SDGs
📗本件論文はコチラから
doi.org/10.1021/jacs.5c07060
🔻本件ポイントはこちら🔻
tohoku.ac.jp/japanese/2025/0…
Asai_lab. retweeted
【注目プレスリリース】β-ラクトンの新たな生合成機構を解明 新たな創薬リードの探索に期待 / 東北大学 research-er.jp/articles/view…
原著論文は以下から読めます。オープンアクセスです。
pubs.acs.org/doi/10.1021/jac…
Asai_lab. retweeted
Ketosynthase Domain Catalyzes β-Lactonization in the #Biosynthesis of the HMG-CoA Synthase Inhibitor Hymeglusin by Mizuki Hirokawa, Taro Ozaki, Kento Tsukada, Akihiro Sugawara, Yohei Morishita, and Teigo Asai in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
