Our team at the @DKFZ, Heidelberg is looking for a Technician Assistant to support cutting-edge cancer Immunology research. If you are motivated to contribute to impactful science please apply or share jobs.dkfz.de/de/jobs/168217/…
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Our team at the @DKFZ, Heidelberg is looking for a Technician Assistant to support cutting-edge cancer Immunology research. If you are motivated to contribute to impactful science please apply or share jobs.dkfz.de/de/jobs/168217/…
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Balu retweeted
Kudos to the international team from 🇨🇳 & 🇺🇸 that conducted this important study published in @Cancer_Cell
Brain metastases are one of most dreaded complications of advanced disease.
Pan-cancer human brain metastases atlas at single-cell resolution
cell.com/cancer-cell/abstrac…
Exciting opportunity to work in a highly collaborative environment at the @DKFZ , Heidelberg, to study the interesting aspects of #genderbias #sexdifference in #cancer progression and #therapy response. Please apply or share .#PostDoc in Sex-Differences in Cancer.
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Balu retweeted
Just out in Science (2025)—a landmark study by @Dr_CJackson et al. identifies a previously uncharacterized immune cell population in human glioblastoma (GBM), termed early myeloid-derived suppressor cells (E-MDSCs) (@MichaelLimMD , @BettegowdaMDPHD , @jihk99 , @dpardol1 ).
These E-MDSCs uniquely infiltrate IDH-wild-type GBM, precisely colocalizing with glioma stem-like cells (GSCs) within pseudopalisading regions—distinct zones known for hypoxia, aggressive invasion, and treatment resistance. Strikingly, the authors uncovered a novel bidirectional signaling axis: GSCs recruit E-MDSCs by secreting specific chemokines, while E-MDSCs reciprocate by releasing potent growth factors (notably FGF11) that drive tumor proliferation via the FGF11-FGFR1 signaling pathway.
Importantly, this critical tumor–immune interaction is entirely absent in IDH-mutant gliomas, due to epigenetic silencing of essential chemokine genes. This discovery not only advances our fundamental understanding of glioblastoma biology but also highlights promising new therapeutic targets specifically tailored for IDH-WT GBM—opening a vital new chapter in treating this notoriously aggressive and therapy-resistant cancer.
Balu retweeted
Do you want to do your #postdoc with the most prestigious #fellowship in Europe? Apply to DKFZ Marie Skłodowska Curie MasterClasses here:
➡️ t1p.de/uay9j
Projects in #cancerresearch #genomics #bioinformatics #immunology #medicaltechnology #epidemiology
@HorizonEU
Balu retweeted
New therapeutic approach for malignant brain tumors: Researchers at the DKFZ and the @unimedizinma developed T-cells with a receptor that recognizes a glioblastoma-specific protein. In lab and mouse experiments, these T-cells destroyed the tumor cells. t1p.de/k3fhq
Balu retweeted
Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on April 25. Talks will feature recent exciting computational and experimental advances and will be live-streamed at satijalab.org/scgd. Please RT/spread the word!
Balu retweeted
Very proud to see our immune-mediated gene therapy strategy for malignant brain cancer #GBM published @TheLancetOncol thank you Pedro Lowenstein for not giving up in spite of all the “almost” insurmountable challenges! To our patients, always! medicalxpress-com.cdn.amppro…
Balu retweeted
🧵Just in time for #FluorescenceFriday: New research from the Venkataramani lab @CellCellPress maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/arti… @ekinreyhann @SvenjaKTetzlaff 1/15
Balu retweeted
Congrats #CancerGrandChallenges team eDyNAmiC on its paper in @NatureGenet ⭐️
By studying > 8000 cancer genomes, the team highlighted ecDNA's role in providing a competitive advantage during cancer progression, treatment response & metastasis.
Read 👇
doi.org/10.1038/s41588-024-0…
Balu retweeted
We are recruiting a postdoc!
Have expertise in RNA biology and want to apply it to neuro and neurodev disorders? Then apply 👇🏼
📌 $73,588 💰
📌 access to postdoc housing 🏠
📌 Support for internationals 🌍
📌 Awesome view 😅
🙏 RT
labs.icahn.mssm.edu/derubeis…
Balu retweeted
Our postdoc colleagues voted to form their union two years ago - since then, they've won a contract that has set industry standards on pay and workplace rights, and enlarged the voice of researchers @IcahnMountSinai. Check out this message of support from our colleagues @spocuaw!
Balu retweeted
New AI-enhanced advanced microscopy method offers promise in better understanding glioblastomas, one of the deadliest brain cancers.
Scientists developed a microscope to penetrate deep brain tissue to observe live brain cells with unprecedented clarity.
embl.org/news/science-techno…
Balu retweeted
We tragically lost our wonderful colleague Sidhanta Nanda, PhD, unexpectedly due to medical condition. He will always be remembered as an incredibly kind friend and co-worker.
A memorial service will be on Sep-24. You can help support his family here:
gofundme.com/f/in-memory-of-…
Balu retweeted
For anyone interested in RNA and cancer (basic and translational research), please consider submitting an abstract for this exciting meeting! We will be choosing lots of talks from abstracts. Should be a great event! #aacrRNA24
Submit an abstract by August 26 for the AACR Conference on RNAs as Drivers, Targets, and Therapeutics in Cancer (November 14-17, Bellevue, WA) chaired by @HowardYChang, Joshua T. Mendell, Anastasia Khvorova, and V. Narry Kim.
bit.ly/460QEdY
#aacrRNA24 @Mendell_lab
Balu retweeted
Thank you @GenesDev for sharing our comprehensive review of the role of the glioma microenvironment 🧠in shaping tumor heterogeneity, progression, and therapeutic responses with the broader research community! Awesome collaboration with rockstars @HambardzumyanL1 @NeuroOncDoc 🤩
Read et al. discuss the heterogeneity in the glioblastoma tumor microenvironment (TME) that builds diverse tumor-supporting niches, and offers TME-targeting strategies in brain cancer therapy. @RRead_Lab @HambardzumyanL1 @NeuroOncDoc
Read the Review:
➡️ tinyurl.com/gd351427
Balu retweeted
Introducing our new on-demand collection designed to guide you through the fundamental concepts and methods in #FunctionalGenomics, #Proteomics, #Metabolomics, and more: ebi.ac.uk/training/online/co… #OpenAccess #Bioinformatics #LifeSciences #SpatialOmics #DataScience
ALT Graphics card showing EMBL-EBI on-demand training collection about Methods and resources for omics studies, a curated collection of EMBL-EBI on-demand training. Graphics image credit: Karen Arnott, Creative Team/EMBL
Balu retweeted
Very excited to present a @bioRxiv paper from our lab on our human organoid tumor transplantation (HOTT) system to study glioblastoma! This work was led by the very talented project scientist Dr. Weihong Ge + exceptional graduate student @RyanKan20 (1/18)
biorxiv.org/content/10.1101/…
