The Bates Lab @ The University of Colorado | Anschutz Medical Campus. Mentor, Teacher, Developmental Biologist, Geneticist, and Mama to two littles.
AMC, Aurora CO
Joined September 2018
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Emily Bates Lab retweeted
#Cleftpalate is a failure of the roof of the #mouth to close and is one of the most frequent #birthdefects affecting 1 in every 1000-2000 babies. A new study reveals the cellular heterogeneity and molecular underpinnings of #palate development. doi.org/10.1002/dvdy.573
Emily Bates Lab retweeted
In an ideal world, we would recommend avoiding cigarettes and vapes just like how we say not to drink alcohol during pregnancy. Ultimately, that conversation should occur between the mother and their doctor. Our research will hopefully help clinicians determine best practices
Emily Bates Lab retweeted
Another great #bioelectricity paper from the @BatesLab!
Endoplasmic Reticulum Calcium Mediates Drosophila Wing Development
liebertpub.com/doi/full/10.1…
Emily Bates Lab retweeted
Check out our 4th year student @karliswenson’s new preprint, available now on bioRxiv
Check out our latest work that shows fetal CBD exposure increases thermal pain sensitivity, impairs cognition, and reduces prefrontal cortex excitability in a sex-specific manner, now out on bioRxiv!!! biorxiv.org/content/10.1101/…
Emily Bates Lab retweeted
Shout out to this incredible new work from @CUDevBio and @karliswenson and @BatesLab! I love seeing you thrive!!!! 🧠 🤰🏼 🧬 🔬
My first first-author paper is now available on bioRxiv!! We found that #fetal exposure to #cannabidiol #CBD increased male offspring pain sensitivity, decreased female offspring cognition, and altered female prefrontal cortex excitability biorxiv.org/content/10.1101/…
Emily Bates Lab retweeted
This work highlights (some of) the potential risks of consuming #cbd and #cannabis products while #pregnant, and should be used to help inform clinical recommendations and public health campaigns on education biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
This work is incredibly important as thousands of #pregnant people suffer from debilitating nausea and vomiting of #morningsickness and often use #cbd or whole #cannabis products to alleviate their nausea, without much information on safety or potential risks – at Denver, CO
Emily Bates Lab retweeted
All together, we have shown that fetal #cbd exposure, in a mouse model, increases male thermal pain sensitivity, decreases female offspring cognition, and alters female offspring neuronal excitability biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
Tori then completed 2 photon imaging of pyramidal neurons from the prefrontal cortex and found that female #cbd exposed offspring has less target spine uEPSCs than vehicle exposed offspring biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
Specifically, @ephyswizard found that female #cbd exposed offspring prefrontal cortex samples elicited less action potentials and required higher mV and higher current to elicit an action potential compared to vehicle exposed controls biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
@ephyswizard Luis completed #ephys experiments on prefrontal cortex sections from mice with fetal #cbd exposure and vehicle and found that female offspring, but not males, had alterations in neuronal excitability biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
To understand if the offspring showed alterations in morphology and excitability in the prefrontal cortex, an area that mediates cognition, we partnered with @ephyswizard Luis and Tori in Won Chan Oh’s lab at @CUPharmacology – at Denver, CO
Emily Bates Lab retweeted
Male offspring, on the other hand, showed no cognitive effects following fetal #cbd exposure biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
We used the puzzle box test which measures a mouses ability to learn and remember the way into a dark cozy area in a maze. We found that female offspring of fetal #cbd exposure had significantly decreased cognition compared to vehicle exposed controls biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
#cbd binds multiple receptors other than #trpv1, including 5HT1a which is a #serotonin receptor. Because serotonin regulation is very important in fetal brain development, and present in the prefrontal cortex which mediates cognition, we tested offspring cognitive outcomes – at Denver, CO
Emily Bates Lab retweeted
Our #TRPV1 knockout mice did not show increased thermal pain sensitivity following fetal exposure to #cbd biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
This finding was reliant on the presence of the #trpv1 receptor, a receptor that responds to heat, acidic conditions, and capsaicin, and is also activated by #cbd biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
We found that #fetal #cbd exposure increased sensitivity to thermal pain via the Hargreaves test in male offspring, but not female offspring. This means male offspring responded faster to to a hot pain stimulus than vehicle exposed offspring biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
We also found fetal #cbd exposure also did not affect offspring compulsivity via the marble burying test nor spatial memory via the Y maze test biorxiv.org/content/10.1101/… – at Denver, CO
Emily Bates Lab retweeted
We found fetal #cbd exposure did not alter male or female offspring #anxiety at puberty via the open field test, light dark box, nor elevated zero maze test biorxiv.org/content/10.1101/… – at Denver, CO