Principal Scientist @genentech, Epigenetics and Chromatin Biology.
Joined October 2018
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Exciting news, first preprint from my group @Genentech, led by Vasumathi Kameswaran. We studied TEAD/YAP-addicted mesothelioma cells, and how they resist a pan-TEAD inhibitor. They revert to an old-school way of gene regulation…promoters: biorxiv.org/content/10.1101/…
We introduce the "Promoter-switch" concept as an adaptation mechanism in cancer cells when selective pressure targets TEAD/YAP-bound distal elements, shifting reliance to promoter-centric gene regulation.
Bence Daniel retweeted
Less than one month away from abstract submission deadline for the 2025 GRC/GRS Genome Architecture meeting at the beautiful beach in California. Don't miss it!
Chromatin folks: don't miss GRC/GRS Genome Architecture in Cell Fate and Disease, June 15-20 2025 Ventura, CA. Registration deadline: Mar 18, 2025. grc.org/genome-architecture-…
Bence Daniel retweeted
Happy to share our latest study asking whether exhausted T cells can form memory? Terrific work led by Colin Raposo and @InflammatoryDC
Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade biorxiv.org/content/10.1101/… #biorxiv_immuno
Bence Daniel retweeted
On #IDWGS, we celebrate women transforming the way we tackle global challenges. From breaking stereotypes to mentoring the next generation, their contributions are shaping the future. We're proud to highlight the stories & wisdom of the #womeninscience at Cartography.
Bence Daniel retweeted
PERFF-seq is out today in @NatureGenet! Our recent thread summarizes why we are excited about the prospects of programmable nucleic acid cytometry for studying rare cell states.
nature.com/articles/s41588-0…
What a PERFFect day to share our new preprint!
With @tsion_abay #BobStickels @MerilTakizawa @ChaligneRonan and @Satpathology, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.1101/… 1/n
Bence Daniel retweeted
I am excited to join storied biotech pioneer @Amgen as Chief Scientific Officer and Head of Research. I look forward to partnering with my new colleagues to deepen understanding of biology and develop solutions to the most pressing medical challenges tinyurl.com/5n86sku5
wow, an amazing synthetic biology approach, congrats to all involved!
Happy to share our new work describing DESynR genes!
The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable high-throughput generation and screening of base-pair level sequence evolution (mutagenesis, directed evolution, CRISPR, etc), we lack similar scalable technologies for domain-level evolution.
We developed a high-throughput combinatorial molecular assembly method to generate thousands of barcoded novel genes from the domain building blocks of natural genes, termed DESynR (Domain Engineered via Synthesis and Recombination) genes.
Bence Daniel retweeted
Excited to share our work with @HalaszLaszlo, now on bioRxiv, on how the systemic effect of a tumor can remodel the epigenomic landscape in peripheral monocytes and shape how they respond to the tumor microenvironment.
biorxiv.org/content/10.1101/…
Bence Daniel retweeted
🚨We are hiring a Research Assistant to help us supercharge CAR T cells!
Candidates of all experience levels are encouraged to apply. Some lab experience is required, mouse experience is preferred. 2-year minimum commitment.
Please retweet!
Apply here: chop.wd5.myworkdayjobs.com/C…
