Bryan Fraser (@BryanFraser19) profile picture

Bryan Fraser

@BryanFraser19

Biochemist/chemical biologist developing novel COVID-19 and cancer therapeutics

Joined April 2021
  • Tweets3
  • Following16
  • Followers4
First (first author) publication! Working with a few great teams to make this project a success!
Nature Chemical Biology (@nchembio) profile pictureNature Chemical Biology@nchembio8 Jun 2022
.@frbenard and colleagues express and solve a crystal structure of TMPRSS2, a human protease involved in entry and pathogenesis of SARS-CoV-2. Free to read link at rdcu.be/cPfbU
Image from Nature Chemical Biology (@nchembio)
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A fun bit of protein engineering to replace TMPRSS2's native activation sequence with one that can be recognized by another protease, enteropeptidase, and produce a highly pure and active TMPRSS2 enzyme
Image from Bryan Fraser (@BryanFraser19)
Cheryl Arrowsmith (@CherylArrowsmi1) profile pictureCheryl Arrowsmith@CherylArrowsmi125 Jun 2021
Check out our preprint on TMPRSS2 structure, function & inhibition. @BryanFraser19 @SerapBeldar make enzyme of unprecedented purity, specific activity with novel activity on #SARSCoV2 Spike. @francoisbenard L.Halabelian @thesgconline @UBC @UofT biorxiv.org/content/10.1101/…
Image from Cheryl Arrowsmith (@CherylArrowsmi1)
Just released today! 3D structure of (Nafamostat-bound) TMPRSS2, the protease that processes SARS-CoV2 S protein for infection. Outstanding collaboration with B Fraser & @frbenard @BCCancer @UBC, S Beldar & L Halabelian @thesgconline, @uoftmedicine, @PMResearch_UHN PDBID:7MEQ
Image from Cheryl Arrowsmith (@CherylArrowsmi1)
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