Carl DeSelm MD PhD (@CarlDeSelm) header
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Carl DeSelm MD PhD

@CarlDeSelm

Physician Scientist, Radiation Oncologist, developing more effective CAR immunotherapy for incurable diseases

 Washington University in St. Louis
sites.wustl.edu/deselmlab/
Joined June 2012
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Photo by Carl DeSelm MD PhD (@CarlDeSelm)Photo by Carl DeSelm MD PhD (@CarlDeSelm)Photo by Carl DeSelm MD PhD (@CarlDeSelm)Photo by Carl DeSelm MD PhD (@CarlDeSelm)
JUST PUBLISHED @NatureComms! Research led by Tianyi Liu, Felix Feng & @CarlDeSelm discovered cancer cells have a "repair crew" led by ATG9A that quickly fixes damage caused by macrophages! This gives new strategies for effective immune therapies. rdcu.be/euijG
Image from WashU Medicine Radiation Oncology (@WashUMedRadOnc)
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First CAR-M outside of cancer! A CAR was used to direct macrophages to take up and resorb amyloid in Alzheimer's diseased mice. This CAR could be repurposed to target and resorb any unwanted product in the body. #ACT #CAR #immunotherapy insight.jci.org/articles/vie…
Image from Carl DeSelm MD PhD (@CarlDeSelm)
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#Immune cells infected with #HIV can rapidly program their own death to prevent viral spread with the help of a new therapeutic strategy. Great work Qiankun Wang, Liang Shan, and team – and Jack Tang for helping capture the process live. Wang et al, this month’s issue of Science.
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Honored and humbled to have received the 2020 Agilent Early Career Professor Award for work on #cancer #immunotherapy. Looking forward to the next steps and continuing to work with a great team.
https://www.wallstreet-online.de/nachricht/13030818-agilent-early-career-professor-award-presented-to-carl-deselm, https://www.businesswire.com/news/home/20201014005151/en/

ALT https://www.wallstreet-online.de/nachricht/13030818-agilent-early-career-professor-award-presented-to-carl-deselm, https://www.businesswire.com/news/home/20201014005151/en/

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#Pancreatic #cancer systemically impairs #DC development. But it can be restored. Below, a single cross-presenting DC from a mouse pancreatic tumor interacts with and activates several CD8 T-cells. Great work Samarth Hedge, David DeNardo and team. Hedge et al, Cancer Cell 2020.
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Green flash = calcium activation; blue = sorted CD8 T-cells; center cell = sorted #dendritic cell.
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Carl DeSelm MD PhD retweeted
Gunjan Shah (@GunjanLShah) profile picture
Gunjan Shah@GunjanLShah28 Oct 2018
Congrats Joanna Yang on great presentation of Cohort 3 of BV-AVD + CVRT in Early Stage Unfavorable HL! @ILROGTeam @CMoskowitzMD @AchyYahalom @DrAnitaKumar #ISHL11 – at Cologne, Germany
Image from Gunjan Shah (@GunjanLShah)
Image from Gunjan Shah (@GunjanLShah)
Image from Gunjan Shah (@GunjanLShah)
Image from Gunjan Shah (@GunjanLShah)
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The first evidence for adding RT to the standard CAR T cell regimen mskcc.org/blog/adding-low-do…
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