@CassaLabBWH

Computational Genetics Brigham and Women's Hospital | HMS Developing clinical prediction methods in genomic medicine.

 Boston, MA
genetics.bwh.harvard.edu/wiki/cassa/
Joined August 2021
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Cassa Lab retweeted
Chris Cassa@ccassa13 Jun 2023
I’m excited to share REGatta, a project by @James_D_Fife from @CassaLabBWH which uses biobank data to estimate the clinical risk of rare variants within regions of established disease genes – Open access link @AJHGNews authors.elsevier.com/a/1h8Og… 🧵
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📢New work from our lab in @NatureComm! Our article describes PepSEq, a high-throughput approach to measure influences of peptide fusion on prime editing efficiency. 🎉Joyful effort by members of our lab led by @minja_bio nature.com/articles/s41467-0…

Peptide fusion improves prime editing efficiency

Nature Communications - Prime editing enables search-and-replace genome editing but is limited by low editing efficiency. Here the authors present PepSEq, a high-throughput method for screening a...

nature.com
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New work from our lab showing that use of small molecule inhibitor can change mutational outcomes of both SpCas9-NG and KKH-SaCas9 toward 1-bp insertions. nature.com/articles/s41467-0…
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