MSc bioinformatics, UBC. Head full of yarn scraps, bloodstream full of bubble tea
Canada
Joined July 2020
- Tweets93
- Following52
- Followers43
- Likes299
1/ Why are eukaryotic gene regulatory networks (GRNs) so much more complex than prokaryotic ones?
In our new preprint, @CarldeBoerPhD and I investigated the role that recombination, a key step in eukaryotic reproductive strategies, plays in this problem! biorxiv.org/content/10.1101/…
1
36
11/ Our simulations suggest that, rather than being a direct target of selection, GRN complexity may arise as a byproduct of other evolutionary processes. To close things out, here’s a GRN evolution animation. Watch how fitness and complexity change as the population evolves! 🎥
1
31
12/ For more results and full details on the simulation framework, take a look at our preprint! biorxiv.org/content/10.1101/…
12
Madison Chapel retweeted
0/ Essential reading for anyone training or using sequence-function models trained on genomic sequences! 🚨 In our new preprint, we explore the ways homology within genomes can cause leakage when training sequence-based models and ways to prevent it
1 / Interested in how genetic variants influence complex traits? In our new preprint, we show that variant effects depend on the polygenic background in which they occur, and why it is critical to consider polygenic background when studying complex traits. biorxiv.org/content/10.1101/…
9/ Similarly, the dependence on polygenic background means that selection coefficients for the same variant vary across populations, time, individuals, and environments – instead of a single value, they may be better represented as a distribution.
1
2
514
10/ It’s time to shift how we think about variants – instead of associating each variant with a discrete impact on disease risk, they instead have context-dependent distributions of effects. For more details – and more examples! – check out our preprint! biorxiv.org/content/10.1101/…
3
445