@ChariMN

Scientist at @altos_labs // PhD @AgardLab (UCSF) studying protein folding using #cryoEM // UT Austin ‘16

 San Francisco, CA
Joined April 2012
  • Tweets10
  • Following264
  • Followers56
Very happy to have my grad school research published! This was a really fun project driven by a great collab with @WangyrRay. How do Hsp70 and Hsp90 cooperate to unfold a client protein? How does Hsp90 refold and reactivate a client protein? How do co-chaperones help? See below!
Agard Lab@AgardLab24 Dec 2021
Very excited to announce our two new papers! #CryoEM structures demonstrate how Hsp70 and Hsp90 cooperate to regulate the folding and function of a model client, the glucocorticoid receptor. First authors @WangyrRay and @ChariMN nature.com/articles/s41586-0… nature.com/articles/s41586-0…
1
4
19
Excited to share the, now published, final version of my grad school research! Here are a few PhuN highlights from the full story. 🧵 #phage #jumbophage #cryoem nature.com/articles/s41467-0…

The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice

Nature Communications - To protect from host attack, numerous jumbo bacteriophages establish a micron-scale, protein-based structure to enclose their replicating DNA. Using cryoEM, the authors show...

nature.com
6
13
4
46
10,379
The jumbo-phage phi-PA3 encloses its replicating genome in a *beautiful* symmetrically flexible lattice! Congratulations to an amazing mentor and friend @ENieweglowska nature.com/articles/s41467-0…

The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice

Nature Communications - To protect from host attack, numerous jumbo bacteriophages establish a micron-scale, protein-based structure to enclose their replicating DNA. Using cryoEM, the authors show...

nature.com
1
12
1
46
3,960
Congrats Eliza!!!
Eliza Nieweglowska@ENieweglowska7 Apr 2022
Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice! biorxiv.org/content/10.1101/…

The ϕPA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice

A growing number of jumbo bacteriophages, with genomes exceeding 200 kb, have been found to establish a Phage Nucleus—a micron-scale, proteinaceous structure encompassing the replicating phage DNA....

biorxiv.org
Cryo-EM amazingness!
Nature Portfolio
@NaturePortfolio4 Nov 2020
This week on the Nature cover: Atoms in focus. Single-particle cyro-EM powers protein imaging at atomic resolution. Browse the issue here: go.nature.com/3mRQH3X
1
2
Our preprint is out! How the glucocorticoid receptor (GR) is reactivated by the molecular chaperone Hsp90 and the co-chaperone p23, revealed by cryo-EM
bioRxiv@biorxivpreprint14 Sep 2020
GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex biorxiv.org/cgi/content/shor… #bioRxiv
4
1
9
In response to threats to our public lands, @TheNorthFace and @Patagonia are committing an additional $100K annually to @ConservationAll.
23
186
26
514
Load more