@DASLab_MSKCC

Developing cutting-edge therapeutics for cancer treatment @sloan_kettering. Tweets are from lab members, not from Dr. Scheinberg, unless signed -DAS.

 MSKCC
mskcc.org/research/ski/labs/david-scheinberg
Joined September 2019
  • Tweets115
  • Following217
  • Followers924
9Media
Congratulations to my husband, Dr. Bourne!! @TheBourneImmuno I'm so proud of you. It's an honor to be along for the ride.
Dr. Christopher Bourne (he/him)@TheBourneImmuno21 Apr 2023
I successfully defended my thesis. I am now Dr. Christopher Michael Bourne!
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Scheinberg Lab retweeted
Mamadou A. Bah@M_AlphaBah21 Apr 2023
Congratulations to Dr. Bourne (@TheBourneImmuno) my younger big brother for an incredible thesis today! You’re truly an inspirational person in and out of the lab. A phenomenal scientist, dedicated DEI activist, and a monster of a cyclist! UPenn is incredibly lucky to have you!
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Fantastic talk by @emma_reynaud99 wrapping up months of amazing work imaging CAR T cells in action diagnosing & treating cancers @MSKCancerCenter @LabKrebs @DASLab_MSKCC @SchuringaJan Larsonlab #theranostics
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Scheinberg Lab retweeted
Thomas Gardner@TJJardinero30 Dec 2021
Excited to share my work from @DASLab_MSKCC lab out today in @nchembio where we develop CAR-T cells that produce small molecule drugs at the tumor site. This is an exciting step forward in the utilization of engineered cells for drug delivery! nature.com/articles/s41589-0…

Engineering CAR-T cells to activate small-molecule drugs in situ

Nature Chemical Biology - The synthetic enzyme-armed killer (SEAKER) approach equips chimeric antigen receptor (CAR)-T cells with the capacity to express enzymes that process anticancer prodrugs at...

nature.com
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Stay tuned! This is a massive collaboration across multiple labs and disciplines at @sloan_kettering @WeillCornellGS @WeillCornell !!
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One critique of this platform that uses bacterial enzymes is that host immune responses will reject it. In my thesis work, I adapt this project in fully immunocompetent mouse models. We've had very promising efficacy results so far!
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In our @DASLab_MSKCC paper we demonstrate that T cells can be engineered to release small molecule chemotherapies at the tumor site. We do this using bacterial enzymes. In the current paper, we use immunodeficient mouse models as a human proof of concept.
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2.5 years of revision and over 5 years of collaborative work, CONGRATULATIONS to @TJJardinero , @DASLab_MSKCC and all others who contributed to this manuscript 🎉🎉🥳🥳. This novel platform will change adoptive T cell therapy. My thesis work will build on this. More info 👇🏾👇🏾👇🏾
Thomas Gardner@TJJardinero30 Dec 2021
Excited to share my work from @DASLab_MSKCC lab out today in @nchembio where we develop CAR-T cells that produce small molecule drugs at the tumor site. This is an exciting step forward in the utilization of engineered cells for drug delivery! nature.com/articles/s41589-0…

Engineering CAR-T cells to activate small-molecule drugs in situ

Nature Chemical Biology - The synthetic enzyme-armed killer (SEAKER) approach equips chimeric antigen receptor (CAR)-T cells with the capacity to express enzymes that process anticancer prodrugs at...

nature.com
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Woohoo! My co-first author paper is finally in press! The other co-first author is a Black woman surgeon. I felt extremely honored when Angel asked me to help finish the project after her year in the @DASLab_MSKCC. A brief thread on the findings follows:
Scheinberg Lab@DASLab_MSKCC25 May 2021
Our paper on the immunopeptidome of CDK4/6 inhibitor treated breast cancer cells is out now! Congratulations to Angel Charles, @TheBourneImmuno and @MgKlatt and all others who helped bring this project to fruition! tandfonline.com/doi/full/10.…

Low-dose CDK4/6 inhibitors induce presentation of pathway specific MHC ligands as potential targets...

Cyclin dependent kinase 4/6 inhibitors (CDK4/6i) lead to cell-cycle arrest but also trigger T cell-mediated immunity, which might be mediated by changes in human leukocyte antigen (HLA) ligands. We...

tandfonline.com
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Scheinberg Lab retweeted
PhDeg (she/her)@deg_macek15 May 2021
Ty DAS - I know you’ll miss me asking you annoyingly personal questions and telling you you’re wrong in lab meeting 😏🙃😌 @DASLab_MSKCC also goodbye to my Twitter fans as I pass over the DAS lab Twitter 👑 to @TheBourneImmuno xx degan
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Exciting news! My preprint manuscript for my undergraduate honors thesis work is up on @biorxivpreprint! We explored the contributions of the secretory pathway in seamless tube development in the fruit fly tracheal system using confocal microscopy. biorxiv.org/content/10.1101/…

Regulators of the secretory pathway have distinct inputs into single-celled branching morphogenesis...

Biological tubes serve as conduits through which gas, nutrients and other important fluids are delivered to tissues. Most biological tubes consist of multiple cells connected by epithelial junctions....

biorxiv.org
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Scheinberg Lab retweeted
PhDeg (she/her)@deg_macek19 Apr 2021
This is what a PhD scientist looks like, if ya didn’t already know
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Scheinberg Lab retweeted
PhDeg (she/her)@deg_macek19 Apr 2021
I have a PhD and I’m not even a little ashamed to brag about it
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We’re honored to share that Break Through Cancer was recently recognized by @Potus. We are ready for the challenge of making real headway in the most complex cancers: ow.ly/lIBD50DN6T0 #BreakThroughCancer
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MSK is proud to be a founding member of @break_cancer, a newly launched foundation aimed at accelerating collaborative research, clinical trials, and cures for the deadliest cancers. bit.ly/2NYyhCH
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LISTEN YALL... The Emerald Foundation cold emailed us and said, "We want to partner with you to fund a Black scinetist". This is a legit funding opportunity. 75,000 as a postdoc and 100,000 as a transitioning faculty. If you are a Black scientist, APPLY!
BlackinCancer@BlackinCancer12 Feb 2021
In pursuit of our mission to highlight Black excellence in cancer research and medicine, Black in Cancer is proud to announce our Inaugural Postdoctoral Fellowship in collaboration with the Emerald Foundation.
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Scheinberg Lab retweeted
Timothy Chan@GeneCollector11 Jan 2021
Looking for a postdoc position? We have openings focused on exciting and high impact areas in immuno-oncology or cancer genomics. If interested, email [email protected]
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Please RT. New position open in the Laughney Lab to use single cell genomics to study inflammation and cancer. Funded by a multi-PI #R01 with @Samuel_Bakhoum. Great collaborative environment btw @WeillCornell and @sloan_kettering More info: laughneylab.com #sciencetwitter
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#MSKHealthcareHeroes have begun rolling up their sleeves to receive the #COVID19 #vaccine joining frontline #HealthcareHeroes from across the country. While this is an essential step, still wear your 😷 & practice social distancing. Help save lives. Get immunized 💉 #IGotTheShot
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Are you an underrepresented scientist from NYC? Do you want to combat vaccine hesitancy and increase uptake in Black and Brown communities in NYC? @UshmaNeill , @AbrahamAragones and I are doing an outreach campaign to local NYC schools about vaccines! We need volunteers! See 👇🏾
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