D. E. Shaw Research develops and uses paradigm-shifting computational technologies to reshape the process of drug discovery.

Joined April 2020
We are hiring for our computing infrastructure and information security teams. Opportunities include: • Information Security Engineer, Agentic AI • Systems Engineer, Servers/Cloud/Data • Systems Engineering Lead Learn more and apply here: deshawresearch.com/current-o…
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We'll be hosting a recruiting talk at Seoul National University on Tuesday, July 14 (3:00 PM; Room 208, Lotte International Education Hall). Join us to learn about our current research, drug discovery, machine learning, and engineering projects, as well as open positions.
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We'll be hosting a recruiting talk at KAIST on Monday, July 13 (5:30 PM; Chung Kunmo Conference Hall). Join us to learn about our current research, drug discovery, machine learning, and engineering projects, as well as open positions. Food will be served!
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We’re excited to be at ICML 2026! Sign up using the link below to keep up with our events at ICML and opportunities to connect with our team. tinyurl.com/Sign-up-here-DES… #ICML2026
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D. E. Shaw Research will be at ICML 2026! Come find us to chat with our team, explore our work, and grab a cup from our espresso bar! #ICML2026
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Interested in working on generative ML models (including LLMs) and agentic AI systems for drug discovery? Opportunities include: • ML Researcher and Engineer • LLM Researcher and Engineer • Software Developer, Agentic AI Learn more and apply here: deshawresearch.com/current-o…
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We'll be hosting a recruiting talk at ETH Zürich on Wednesday, April 15 (6:15 PM; Room G3, ETH HG). Join us to learn about our current research, drug discovery, machine learning, and engineering projects as well as open positions. Food and drinks will be served!
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We'll be hosting a recruiting talk at EPFL on Monday, April 13 (5:15 PM; Room BC 420). Join us to learn about our current research, drug discovery, machine learning, and engineering projects as well as open positions. Food and drinks will be served!
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We’ll be hosting a recruiting talk at the University of Toronto on Thursday, March 26 (5:15 PM; Room 110, Ramsay Wright Laboratories). Join us to learn about our research, drug discovery, machine learning, and engineering projects as well as open positions. Food will be served!
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We'll be hosting a recruiting talk at the Université de Montréal on Tuesday, March 24 (11:30 AM; Salle 1355, André-Aisenstadt Pavillon). Join us to learn about our research, drug discovery, machine learning, and engineering projects as well as open positions. Food will be served!
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The paper, “Validation of a model of rheumatoid arthritis using mice reconstituted with patient peripheral blood mononuclear cells,” which we contributed to, has been published in Disease Models & Mechanisms. journals.biologists.com/dmm/…
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Our Head of Machine Learning will be presenting an exhibitor spotlight talk in Exhibit Hall A,B at #NeurIPS2025 today. Stop by to hear more about our work and how we use large-scale synthetic data from our Anton supercomputer to power ML models that accelerate drug discovery.
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D. E. Shaw Research will be at NeurIPS 2025! Come find us to chat with our team, explore our work, and grab a cup from our espresso bar! #NeurIPS2025
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We’re excited to be Gold Sponsors at this year’s @PyTorch Conference! Stop by our booth (G14) to learn more about our work.
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We have opened our intern applications for Summer 2026 in NYC! Undergrad and grad interns could work on projects such as applying ML (including LLMs) to drug discovery, building and deploying AI-enabled systems, developing scientific software, and more. apply.deshawresearch.com/car…
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Our article “An RNA-mediated DNA melting mechanism for CRISPR-Cas9” was released today on bioRxiv. biorxiv.org/content/10.1101/…
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Several members of our machine learning team will be attending #ICML2025. Come find us to chat with our team, explore our work, and grab a cup from our espresso bar!
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Join us to work on LLMs for drug discovery, including scaling/optimizing large model training and inference workflows on our cutting-edge infrastructure, pre-training, post-training, and multimodal learning and integrating non-text modalities. apply.deshawresearch.com/car…
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Our article “Design of antigens to present a tumor-specific cryptic epitope” has been released on bioRxiv. biorxiv.org/content/10.1101/…
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This article has been published in Scientific Reports. nature.com/articles/s41598-0…
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We welcome summer intern applications from undergrad and grad students for our CS, ML, and biochemistry efforts to work on projects such as developing ML models for drug discovery, ML kernels/infrastructure, and large-scale data management/analysis code. apply.deshawresearch.com/car…
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