Scientist | Postdoc @georg_e_winter lab @cemm_news | PhD @clausen_lab | TPD | Proximity inducing Pharmacology | Chemical Biology | Proteomics
Joined November 2015
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Excited to share our recent work from the @clausen_lab published in @CellPressNews as part 2 of the BacPROTAC story. Here we use targeted protein degradation as an antibiotics strategy to induce self-elimination of essential mycobacterial Clp proteins. sciencedirect.com/science/ar…
Grateful to be recognized for my PhD work in the @clausen_lab at @IMPvienna by receiving the Vienna BioCenter PhD award 2023. It was great to be back there and present my story on BacPROTACs in front of this great symposium crowd. Congrats to my fellow awardees!!
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I am very honored to have been selected for this years Life Science Research Award by the @ogmbt_ylsa in the category of applied research for our work on BacPROTACs published earlier this year. Thanks to a fantastic team for making this happen!
oegmbt.at/awards/research-aw…
A special thanks to Sabryna Junker for leading this project together with me. I’m very grateful to @clausen_lab and @M_plus_H for their guidance on this project and to the @IMPvienna for providing a fantastic working environment.
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Happy to share that I’ll be joining the @georg_e_winter lab at @CeMM_News this autumn as postdoc. Already very excited to develop and apply novel chemical biology approaches to drug the undruggable! 💊🧬🧪
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It was a pleasure to present my work on bacterial PROTACs (@clausen_lab) at this incredible #BioMedConference here in Barcelona. Thanks to @CrisMayorRuiz and @georg_e_winter for making this amazing event happen, can’t wait for a continuation 🙌
After the coffee break, David Hoi: next-generation BacPROTACs #BioMedConference @IRBBarcelona @clausen_lab
Happy to share this!
Congrats to David Hoi PhD @DHoi93 (@clausen_lab) who successfully defended his thesis entitled 'BacPROTAC induced elimination of mycobacterial ClpC1 and its isolated substrate receptor ClpC2' - Well done! @univienna @MedUni_Wien @IMPvienna @IMBA_Vienna @gmivienna @MaxPerutzLabs
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Ready for #ASMS2022
Obligatory airport picture of the partial @BroadProteomics lab, on the way to #ASMS2022
Come and find us in Minneapolis - we have a lot of exciting career opportunities to share!
@asmsnews @broadinstitute
In collaboration with @DHoi93
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Excited to see this work out and happy to have been part of this collaboration! SAR striking once again resulting in potent compounds that show antitubercular effects in vivo and a synergistic effect with first line Mtb drug. @PayneResearch @clausen_lab @Jackson_Lab @oehlerslab
Our work on the development of ecumicin/ohmyungsamycin A analogues targeting Mtb ClpC1 is out now in J Med Chem. Our lead analogue is selective, potent, bactericidal and active in vivo. A great collaborative effort! @clausen_lab @Jackson_Lab @oehlerslab pubs.acs.org/doi/abs/10.1021…
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Nice tool to quickly get the most info out of your proteomics data.
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Next level of „Targeted protein modification“!
Ever wanted to dephosphorylate just a single phosphoprotein instead of blocking all downstream kinase substrates with a kinase inhibitor? Check our new PoC paper describing PhosTACs that recruit phosphatases to selected phosphoproteins. #PhosTACs pubs.acs.org/doi/full/10.102…
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Join us now! #BuildingBridges2021
"Building Bridges" has started with scientists joining us from 45 countries! We are looking forward to 2 exciting days!
#BuildingBridges2021
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Check out the speaker line up for this years VBC PhD symposium!
Join “Building Bridges” online to enjoy some cutting-edge science - free of charge & inclusive to people from anywhere in the World! Register via tiny.cc/VBCPhDSymp.
4/5 November @viennabiocenter. Speakers include:
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Don’t forget to sign up for this one 😉
The Vienna BioCenter PhD Symposium has opened its registration! Join online to enjoy some cutting-edge science - free of charge & inclusive to people from anywhere in the World! Register via tiny.cc/VBCPhDSymp. 4/5 November @viennabiocenter
I’m excited to see the latest preprint from our lab, spearheaded by the amazing @fmorreale_ester!
Excited to share our work on developing bacterial #PROTACs. BacPROTACs hijack the ClpCP proteolytic complex in vitro and in mycobacterial cells, and capture a ClpC-substrate complex visualized by #CryoEM
biorxiv.org/content/10.1101/…
Check out this new preprint on ultra-low input proteomics from an amazing colleague of mine. Happy to see her hard work paying off!
I am beyond excited to finally share our approach on proteome profiling by introducing proteome signatures in ultra-low input samples independent of sample origin at high throughput. @IMPvienna @IMBA_Vienna @TrainingVbc
A short summary:
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Check out this new cool story from our lab!
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That is truly exciting!
The first demonstration that #PROTACs work in humans! The AR degrader ARV110 decreased PSA levels >50%, even in a patient with AR mutations that confer ENZ resistance. meetinglibrary.asco.org/reco…
Check out this new paper from our lab @clausen_lab if you’re interested in the usage of native mass spectrometry for PROTAC analysis!
Native mass spectrometry can effectively predict PROTAC efficacy biorxiv.org/cgi/content/shor… #bioRxiv
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