MD, Cardiologist @uninaIT | Interventional Cardiology PhD Fellow at Cardialysis, Rotterdam |
Rotterdam, Netherlands
Joined August 2022
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Just published in @NEJM !
Together with Dr. Spitzer @spitzertweets , we discuss the DAPT-MVD trial.
doi.org/10.1056/NEJMc2610855
Does its benefit establish prolonged DAPT, or challenge aspirin monotherapy as the comparator for future trials?
#ClinicalTrials #Cardiology #DAPT #NEJM
Domenico Simone Castiello retweeted
Among patients with multivessel coronary artery disease who were in stable condition 1 year after stenting, an additional year of DAPT led to a lower risk of ischemic events than aspirin alone, without increased bleeding. Full DAPT-MVD trial results: nej.md/4wLDIox
Editorial: Balancing the Scales — Extended DAPT in Coronary Artery Disease nej.md/4gAVqpZ
ALT A graph from an Original Article published in the New England Journal of Medicine article titled "Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease." The graph shows major adverse cardiovascular and cerebrovascular events. The trial name, DAPT-MVD, is in parentheses after the title. The NEJM identity sits at the bottom.
Domenico Simone Castiello retweeted
6.5 billion in fraud! If 1/10th would have been invested in clinical trials, all current questions in cardiology would have been solved 🌊🫧
Honoured and deeply grateful to have received the award for the Best State-of-the-Art Review published in 2025 from the journal @EuroInterventio during EuroPCR 2026 in Paris @PCRonline.
Looking forward to the next challenges and opportunities.
#EuroPCR2026 #EuroIntervention
Domenico Simone Castiello retweeted
🏆 Proud moment at #EuroPCR 2026 with the EuroIntervention Award Ceremony celebrating excellence in scientific publishing.
Honouring the best editors, reviewers, and papers of the year for their outstanding contributions to innovation, research quality and the advancement of interventional cardiology.
“And the winner is...”
- Best #EIJonAir: @sbrugaletta & @G_Tarantini01 for “High-risk PCI in surgically ineligible patients”
- Best Flashlight: “Concertina effect mimicking plaque rupture in a patient presenting with acute coronary syndrome” by Nitin Chandra Mohan, Tom Johnson et al.
- Best central illustration: @fra_bendandi in “Development and validation of the D-PACE scoring system to predict delayed high-grade conduction disturbances after transcatheter aortic valve implantation”
- Cory’s Innovation Award: "Single-view angiographic microcirculatory resistance index after primary PCI: the EARLY-MYO-AMR study" by @ZhiwenZhang
- Best Editor: Joanna Wykrzykowska
- Best Reviewer: @FeliceGragnano
- Best Original Research: “Direct oral anticoagulants or warfarin in patients with left ventricular thrombus after ST-elevation myocardial infarction: a pilot trial and a prespecified meta-analysis of randomised trials” by Yaser Jenab, P Sadeghipour, et al.
- Best State-of-the-Art: “Antithrombotic therapy in complex percutaneous coronary intervention” by @DSCastiello, Angelo Oliva et al.
- Most Impactful Paper: “Acute outcomes for the full US cohort of the FLASH mechanical thrombectomy registry in pulmonary embolism” by @CatalinPToma, et al.
👏 Congratulations to our winners!
#InterventionalCardiology #AwardCeremony #EuroIntervention @PCRonline @DFCapodanno @dmylotte @NievesGonzalo1 @robebyrne
Domenico Simone Castiello retweeted
🔥 SIMULTANEOUS PUBLICATION #EuroPCR
This post hoc analysis from the NEO-MINDSET trial explored whether PCI complexity influences outcomes with potent P2Y12 inhibitor monotherapy versus DAPT in patients undergoing #PCI for ACS.
Across complex and non-complex PCI strata, PCI complexity did not significantly modify treatment effects on 12-month ischaemic or bleeding outcomes. Monotherapy was associated with lower rates of clinically relevant bleeding, although no clear net clinical advantage emerged.
🔗 lnkd.in/dBQzXtmt
@PCRonline #CardioEd #InterventionalCardiology
Domenico Simone Castiello retweeted
🔥 #EuroPCR 2026 Major Late-Breaking Trials: Long-term mortality following PCI with DES versus CABG for left main disease
An individual participant data meta-analysis of the SYNTAX, PRECOMBAT, NOBLE and EXCEL trials presented by Brian Bergmark showed no significant difference in all-cause mortality between DES PCI and CABG over 10-year follow-up in patients with left main coronary artery disease suitable for revascularisation.
Read the press release here: pcronline.com/News/PCR-Press…
@NievesGonzalo1 @CuissetDr @nicolasdumonte1
#LeftMain #PCI #CABG #CoronaryArteryDisease #InterventionalCardiology #ClinicalTrials
Domenico Simone Castiello retweeted
POMPEII study: Cangrelor-induced platelet inhibition was ⬇️ in pts w/ compared to w/out STEMI and was ⬇️than that induced by ticagrelor in STEMI pts academic.oup.com/ehjacc/arti… @vlgmrc @espogiov @piccoloraf @me_canonico @DSCastiello @EHJACVCEiC @franzone_anna @llddss80 @CirilloPlinio
Domenico Simone Castiello retweeted
In this study, cangrelor provided effective platelet inhibition during PCI, with low HRPR rates during infusion. Transition to oral P2Y12 inhibitors—particularly clopidogrel—was associated with a transient increase in high residual platelet reactivity. #EIJBestOf
#InterventionalCardiology #Cangrelor #AntiplateletTherapy
🔗eurointervention.pcronline.c…
@GargiuloG83
@espogiov @CirilloPlinio @DSCastiello @IForzano46837 @d_florimonte @FiorenzoSimo @me_canonico @llddss80 @franzone_anna @piccoloraf @vlgmrc
Domenico Simone Castiello retweeted
Presented at #ACC26:
Among patients with a preserved ejection fraction at least 1 year after myocardial infarction, stopping beta-blockers was noninferior to continuing therapy with respect to major clinical outcomes. Full SMART-DECISION trial results: nejm.org/doi/full/10.1056/NE…
@ACCinTouch
ALT American College of Cardiology Annual Meeting Original Article | MAR 30, 2026 | NEJM.org Discontinuation of Beta-Blocker Therapy after Myocardial Infarction (SMART-DECISION) Figure 2. Death from Any Cause, Recurrent Myocardial Infarction, or Hospitalization for Heart Failure.
Domenico Simone Castiello retweeted
𝗣𝗥𝗜𝗠𝗔𝗥𝗬 𝗢𝗨𝗧𝗖𝗢𝗠𝗘: ❌ 𝗡𝗘𝗚𝗔𝗧𝗜𝗩𝗘
Win ratio: 0.85 (95% CI: 0.63-1.15, p=0.30)
• 36.6% favored Impella
• 43.0% favored standard care
𝗠𝗢𝗥𝗧𝗔𝗟𝗜𝗧𝗬 at 24 months:
• Impella: 𝟯𝟮.𝟲%
• Standard care: 𝟮𝟯.𝟰%
HR: 1.54 (0.99-2.41)
Domenico Simone Castiello retweeted
Presented at #ACC26:
Among patients with intermediate coronary lesions, angiography-guided revascularization was noninferior to pressure-wire–based guidance with respect to death, myocardial infarction, or revascularization. FAST III trial results: nejm.org/doi/full/10.1056/NE…
Editorial: Redefining Physiology in the Cardiac Catheterization Laboratory nejm.org/doi/full/10.1056/NE…
@ACCinTouch
ALT American College of Cardiology Annual Meeting Original Article | MAR 29, 2026 | NEJM.org Angiography-Based Physiology to Guide Coronary Revascularization (FAST III) Figure 2A. Death, Myocardial Infarction, or Revascularization.
Domenico Simone Castiello retweeted
Clopidogrel vs aspirin after PCI:
10-year HOST-EXAM follow-up shows lower ischemic and bleeding events with clopidogrel—but no difference in mortality.
Read more: spkl.io/6010A0hCy #ACC26
Domenico Simone Castiello retweeted
Among patients with anterior myocardial infarction, adding low-dose rivaroxaban to dual antiplatelet therapy did not significantly reduce left ventricular thrombus formation at 1 month but increased minor bleeding.
ja.ma/4cF3mo4
Domenico Simone Castiello retweeted
After the two recent meta-analyses published in The Lancet and NEJM, one could argue that the case is settled: following myocardial infarction, beta-blockers should be prescribed to patients with an LVEF <40%, may be considered in those with an LVEF of 40–49%, and in patients with an LVEF ≥50% only if there are other indications, such as hypertension, atrial fibrillation, or heart failure. The guidelines are partially misaligned with the emerging evidence and will most likely be updated in the near future.
Domenico Simone Castiello retweeted
🫀 First-in-human valve-in-valve TAVI in mechanical prostheses
Bench-to-bedside study: disc dislodgement & retrieval followed by successful TAVI.
Published in European Heart Journal.
👉 academic.oup.com/eurheartj/a…
@escardio @PCRonline @secardiologia @CNIC_CARDIO @sacyl @TCTMD
Domenico Simone Castiello retweeted
A comprehensive contemporary overview of Optimal Medical Therapy Targeting Metabolic status (Diabetes & Obesity) for Secondary Prevention after PCI:mdpi.com/3705586
@FeliceGragnano @me_canonico @DSCastiello @espogiov @paolocalabro1 @arturocesaro @DanieleGiacoppo @AGrecoMD
Domenico Simone Castiello retweeted
Here is the usual overview of the papers that attracted the most attention in EuroIntervention in 2025.
I'm pleased with this year’s statistics. The steady increase in the journal’s impact factor over recent years (now 9.5) is translating into a higher volume of submissions, making the selection of the limited proportion of articles we can publish increasingly competitive. The practical consequence is a progressive rise in average quality. Studies that only a few years ago might have been published elsewhere are now appearing in EuroIntervention. A virtuous cycle that we hope to sustain in 2026, with the continued contribution of our reference community of interventional cardiologists, which the journal aims to reflect both academically and in daily practice.
Coronary is back? Among the most cited themes this year are standardization of definitions and endpoints, acute coronary syndromes, physiology- and imaging-guided decision-making, optimization of antithrombotic strategies, and the management of complex patient subsets.
Domenico Simone Castiello retweeted
#DAPT after valve-in-valve #TAVR may be associated with a lower 1-yr incidence of stroke. In contrast, no significant difference was observed for other major ischemic and bleeding outcomes or for premature valve deterioration. jacc.org/doi/10.1016/j.jcin.… #JACCINT @saia_francesco
Domenico Simone Castiello retweeted
Validation of IVUS-defined optimal stent expansion criteria for favorable 1-year clinical outcomes
🔗pcronline.com/PCR-Publicatio…
This individual patient data analysis 🔎 of the 3 largest RCTs evaluating IVUS-guided stent optimisation showed that an MSA > 5.5 mm2 was associated with reduced TVF at one year.
Read this new journal club review ✍️ by @RuxSava and @NicolaRyanI1
#interventionalcardiology
