BMT/CART/Heme Pharmacist
Joined August 2021
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- Following192
- Followers100
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3/ First-read main takeaways:
🧠 Low CNS relapse. Is it ponatinib, the extra IT doses, or both?
❤️ Rare arterial events, only at the 45 mg level (<65 y)
🔄 ~19% went to alloHCT: about half IKZF1plus, the rest presumably MRD+ after 2 blina cycles. Most patients were spared tx.
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Consolidation
💊 Blinatumomab 28 mcg/day CIVI, 4 wks on / 2 off, x 2-5 cycles. Decision for alloHCT after 2 cycles (MRD+ -> alloHCT)
💊 Ponatinib 30 mg continues
💉 Triple IT at day 29 (Complete 9 more doses)
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1/ 🧵Pharm Tx Breakdown Induction
💊 Ponatinib 45 mg QD x 22d if < 65 then drop to 30 mg thereafter. 30 mg QD from the start if ≥65
💊 Prednisone 30 mg/m² BID x24d, rapid taper by day 31
💉 Triple IT x 6 (MTX 12.5 mg / Ara-C 50 mg / hydrocort; 100 mg in the US). Total = 15.
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Here at last!
🧬 GIMEMA ALL2820: Chemo-free beats Chemo + TKI in Ph+ ALL
236 adults randomized 2:1 to ponatinib + blinatumomab vs imatinib + chemo
✅ CHR 94% vs 79%
✅ Deaths 2.5% vs 10.2%
✅ EFS 90% vs 74% (mF/U 2 years)
✅ OS 94% vs 77%
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Devon Stonerock, PharmD, BCOP retweeted
Presented at #EHA2025:
Among patients undergoing stem-cell transplantation from matched related donors, cyclophosphamide plus cyclosporin led to significantly longer GVHD-free, relapse-free survival than standard prophylaxis. Full ALLG BM12 CAST phase 3 trial results: nej.md/3Zpri7z
@eha_hematology
ALT A graph showing the primary end point, which was graft-versus-host disease (GVHD)–free, relapse-free survival.
Devon Stonerock, PharmD, BCOP retweeted
Check out are latest episode, with a star-studded cast! 🤩 "Dex and the Cytokine City: Managing CRS with Bispecifics" #leusm #lymsm #myeloma #TwitteRx @berninini @thisisJamesD @VictoriaNachar @ajperissinotti @PharmacistOnc creators.spotify.com/pod/sho…
We're looking for another pharmacist to join our amazing and growing BMT team in West Michigan! Please reach out if interested in learning more. Apply here for our Clinical Pharmacy Specialist in Blood and Marrow Transplant position @CorewellHealth!
tinyurl.com/9twuxts9
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Devon Stonerock, PharmD, BCOP retweeted
📃📧 Out in the @AJHPOfficial eTOC today!
A relevant topic to daily practice.
academic.oup.com/ajhp/articl…
At #HOPAAC23 I will be sharing our outcomes with fluconazole compared to posaconazole for invasive fungal infection ppx in newly diagnosed AML patients receiving first-line treatment with HMA + Venetoclax. What is your current standard (if any) for IFI prophylaxis? #TwitterRx
77%Posaconazole
12%Fluconazole
5%None
7%It depends (explain)
103 votes • Final results Devon Stonerock, PharmD, BCOP retweeted
This applies to pharmacy clinicians as well! We must not be afraid to critically appraise the literature. Don’t just be a “cheerleader”, even if it results in positive reinforcement from Pharma. Our goal is to help our patients LIVE BETTER and LIVE LONGER! #TwitteRx
Excited to have my PGY1 residency project published. Great work and many thanks to the excellent multi-disciplinary team in helping make this pilot project a success! 🙏
@Docalergias @AlejandroHalloC @SretroPMD #TwitteRx #IDTwitter #AntimicrobialStewardship
📄 New article in @AJHPOfficial: “…resulted in increased use of β-lactam antibiotics, decreased use of second-line antibiotics, and decreased costs without a significant change in the incidence of adverse reactions.”
academic.oup.com/ajhp/advanc… #TwitteRx #MedTwitter
Devon Stonerock, PharmD, BCOP retweeted
Lauren R. Stonerock, PharmD @LStonerockRx - "Pump It Up: An Overview of Diabetic Insulin Pumps". Pharmacology CE available for pharmacists, physicians, physician assistants, and nurse practitioners. #TwitteRx @MayoMedEd
apple.co/3GP1sjg
Devon Stonerock, PharmD, BCOP retweeted
It’s going tibia okay: in today's Pharmacy Grand Rounds, @MayoPharmRes Christopher Cahoon discusses supportive bone health in oncology. #TwitteRx @MayoHemeOnc @HOPArx
Subscribe to our PGR Podcast at ce.mayo.edu/pharmsubscriptio…
apple.co/3VrO61q
Devon Stonerock, PharmD, BCOP retweeted
Devon S. Stonerock, PharmD @DevonStoneRx presents "Pharmacologic Management of Aplastic Anemia"
Pharmacology CE available for pharmacists, physicians, physician assistants, and nurse practitioners.
#TwitteRx @MayoMedEd
apple.co/3fykpgx
Devon Stonerock, PharmD, BCOP retweeted
Extremely grateful for these amazing mentors and wonderful co-residents @MayoPharmRes #oncology that make every day super special. Amanda, @sasoefje @BrianaAmundson, Clay, @Uzo_Chi @DevonStoneRx Donna, couldn’t have done it without you!❤️
#twitterx #ASHP22
Devon Stonerock, PharmD, BCOP retweeted
Mayo Clinic & Mayo Clinic Health System sites are hosting a virtual information session on 11/07 from 5-6 PM central! 11 different PGY2 programs from Rochester (MN), Mankato (MN), and Eau Claire (WI) will be present. Register now!
Devon Stonerock, PharmD, BCOP retweeted
In today's Pharmacy Grand Rounds, @MayoClinic PGY2 Amb Care resident @LStonerockRx gets pumped up talking about diabetic insulin pumps. #TwitteRx #EndoTwitter @MayoClinicEndo @TheEndoSociety @UMichPharmacy
Want a copy of slides or pharmacy CE? Subscribe to our PGR Podcast!
