Simon Flexner Professor & Chair of Path & Lab Med @PennMedicine| Precision Pathology Editor in Chief and podcast Host | Views are my own not Penn’s
Philadelphia, USA
Joined June 2009
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"Precision Pathology was launched to provide a dedicated platform for the rapid, disruptive advances in digital and computational pathology, multiplex tissue-based biomarker, liquid biopsy, and single-cell spatial multi-omics. Pathologist at the frontlines of precision health"
Congratulations to professor Rajendra Singh @mydermpath
An insightful plenary session with Rajendra Singh MD, Professor of Pathology at the University of Pennsylvania, explored how artificial intelligence is transforming everyday pathology workflows.
#PathVisions26
ARTICLE SUMMARY The study investigates why automated and manual tumor-stroma ratio (TSR) scoring in colorectal cancer produces different results. TSR is a prognostic biomarker measuring stromal tissue proportion, but manual assessment suffers from variability KEY FINDINGS: *Tissue segmentation achieved strong performance (Dice scores: 0.896 for tumor, 0.837 for stroma) *Within fixed ROIs, automated quantification agreed better with reference standards than pathologists (κ = 0.84 vs 0.60) *Fully automated TSR scored 24.6 percentage points higher than manual consensus. *Discrepancy sources: ~10 percentage points from ROI selection, ~14 from quantification differences *Case ranking was preserved, but clinical classification at 50% cut-off was not CONCLUSION: Treat automated TSR as a distinct measurement that requires independent prognostic validation, not a direct substitute for manual scoring.
@TheUSCAP @dpatweet @ESP_Pathology @Sciencedirect @PennMedicine
sciencedirect.com/science/ar…
George J. Netto MD retweeted
"Precision Pathology was launched to provide a dedicated platform for the rapid, disruptive advances in digital and computational pathology, multiplex tissue-based biomarker, liquid biopsy, and single-cell spatial multi-omics. Pathologist at the frontlines of precision health"
Nothing like coming to work excited every day. Proud to be a member of @PennMedicine
Precision Pathology Article Alert!
sciencedirect.com/journal/pr…
@TheUSCAP @ESP_Pathology @AACR @ASCO @Sciencedirect @sakhurram @PennPathLabMed @PennMedicine
George J. Netto MD retweeted
🎉 Congratulations to Dr. John Lambris, @LambrisJD, on receiving the impressive 2026 Biochemical Analytics Award from the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) for his groundbreaking research on the human immune system!!
🔬: medlabportal.com/medlabaward…
Excited to share our very first Issue of PRECISION PATHOLOGY!
Grateful to the superb authors, Editorial Board, and Elsevier for their remarkable work in reaching this milestone!
The open-access articles can be downloaded at the link below
sciencedirect.com/journal/pr…
@y_tolkach @ReinhardButtner @mertz_kirsten @cmckin01 @ShukoHarada @darshan_sc @myocache @ESP_Pathology @Sciencedirect @PathologyTweet
@TheUSCAP @Pathologists @ASCP_Chicago @PennPathLabMed @PennMedCSO @PennMedicine @upennlib
George J. Netto MD retweeted
Another impressive paper by Dr. Sara Cherry in @MolecularCell reveals a mechanism that allows cells to fine-tune their antiviral defenses and develop an “immune memory.”
Read the paper🔬: cell.com/molecular-cell/full…
George J. Netto MD retweeted
Happy Friday!!
Another Fun Friday Frozen Section Conference for the Surgical Pathology Fellows! @PennPathLabMed
#PathX #surgicalpathologyfellowship #frozensection
George J. Netto MD retweeted
🎉Congratulations to Dr. Jenna Reece and Dr. Annapurna Saksena, @anusaksena, for being named on the @ASCP_Chicago 2026 40 Under 40 list!!
We couldn't be more proud to have you both on our team!
🔬: ascp.org/membership-resource…
George J. Netto MD retweeted
Welcome aboard, Dr. Akarca and Dr. Sardana to our GI Pathology world! @PennPathLabMed @DrNetto @ktmontone @timchao_mdphd @emma_furth #GIpathology #UPenn #pathology
George J. Netto MD retweeted
Our annual Residency Program Open House be happening tomorrow from 1:30-2:30 pm. We look forward to seeing you there!
Interested in a Pathology Residency Program? Join our open house on Wednesday September 2, 2026 from 1:30 pm - 2:30 pm EST. Register at the link below. We look forward to seeing you there!
🔬: upenn.co1.qualtrics.com/jfe/…
podcasts.apple.com/us/podcas…
NEW EPISODE of PRECISION PATHOLOGY PODCAST
Can Spatial Immune Profiling Improve Oncotype Dx Guidance of Chemotherapy in Breast Cancer?
My guest, @zak_kinsella PhD, from the Royal College of Surgeons in Ireland, with his team of co-authors, observed an association between higher stromal tumor-infiltrating CD8+ lymphocyte (sTIL CD8+) density and poor outcome.
The study suggests sTIL CD8+ density as a candidate biomarker for treatment decisions.
Nature Communications ( 2026); lnkd.in/gu354fg4
@TheABPath @ASCO @AACR @ASCP_Chicago @TheUSCAP -@ESP_Pathology @RCSI_Irl @PennMedicine @Cambridge_Uni
#OncotypeDX
#BreastCancer
podcasts.apple.com/us/podcas…
NEW EPISODE of PRECISION PATHOLOGY PODCAST
Can Spatial Immune Profiling Improve Oncotype Dx Guidance of Chemotherapy in Breast Cancer?
My guest, @zak_kinsella PhD, from the Royal College of Surgeons in Ireland, with his team of co-authors, observed an association between higher stromal tumor-infiltrating CD8+ lymphocyte (sTIL CD8+) density and poor outcome.
The study suggests sTIL CD8+ density as a candidate biomarker for treatment decisions.
Nature Communications ( 2026); lnkd.in/gu354fg4
@TheABPath @ASCO @AACR @ASCP_Chicago @TheUSCAP -@ESP_Pathology @RCSI_Irl @PennMedicine @Cambridge_Uni
#OncotypeDX
#BreastCancer
George J. Netto MD retweeted
Great new paper by @DengYanxiang in @CellPressNews which highlights the first spatial technology that enables simultaneous profiling of 3D genome organization and gene expression within the same tissue section.
🔬: cell.com/cell/fulltext/S0092…
