In our lab, hardcore biochemistry meets physics. And coffee. We are investigating DNA replication through single molecule loupe @MPI_Biochem.
Munich, Bavaria
Joined May 2019
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🚨Incredibly happy to share that our #ERCCoG project #ChromoMemInMotion is funded @ERC_Research. 🍾 We are grateful to the reviewers and panel members ! This was only possible thanks to amazing work of lab members past & present @MPI_Biochem & @TU_Muenchen. A dream come true🙏♥️
🚨New preprint🚨We developed a transverse flow imaging approach to directly visualize bacterial replisomes challenged by topological barriers and discovered a fast rotational mode of replisome operation. Fantastic work by Thomas Retzer and Hamdan Lab! tinyurl.com/replisomerotate
If you have not already, make sure to check-out two fantastic recent preprints from the Patel and Wang labs on the same topic investigated using magnetic tweezers and angular optical trapping:
doi.org/10.1101/2024.10.14.6… and doi.org/10.1101/2024.10.09.6…
We are grateful to TUM and @MPI_Biochem for their support and Margot Riggi for figure help. This would not have been possible without early support from SFB863, forces in biomolecular systems, and the European Research Council.
Duderstadt_lab retweeted
Congrats on the Nomis Award, Elena @LabConti ! Her #NOMIS project aims to discern the structure and biochemical nature of #mRNPs in the brain throughout the #mRNA life cycle.
❗️nomisfoundation.ch/projects/…
Duderstadt_lab retweeted
Out today in @NAR_Open from @cees_dekker lab!!
*DNA supercoiling enhances DNA condensation by ParB proteins*
doi.org/10.1093/nar/gkae936
Together with @Aless322 (and @Gruber_Lausanne ) we show the interaction between partition complex proteins (ParB) and supercoiled DNA!
Duderstadt_lab retweeted
Thrilled to share our new work @biorxivpreprint:
biorxiv.org/content/10.1101/…
Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2
Duderstadt_lab retweeted
Read the latest publication from Danny Nedialkova’s lab and collaborators! In their latest work, they show that increased translation during the maternal-to-zygotic transition sensitizes maternal mRNA decoding rates to #tRNA supply.
❕embopress.org/doi/full/10.10…
@ddnedialkova #RNA
Duderstadt_lab retweeted
Read the latest @Nature Perspective of Kikuë Tachibana's lab:
❗️rdcu.be/dVOZh
Duderstadt_lab retweeted
A tour de force from Carl Wu's lab @JohnsHopkins .- lead author postdoc Robert Louder: Molecular basis of global promoter sensing and nucleosome capture by t... sciencedirect.com/science/ar…
Duderstadt_lab retweeted
We are hiring! Position open for a new assistant professor in the Department of Biophysics & Biophysical Chemistry in @HopkinsMedicine . Considering all areas in experimental and computational biophysics. Please spread the word. apply.interfolio.com/154014
Duderstadt_lab retweeted
What makes for a great DNA-PAINT experiment? How does the fluorescent dye affect the image quality? And how can we use this to extract the most out of our samples?
Check out our paper in @NatureMethods to see what state-of-the-art DNA-PAINT can do for you!
doi.org/10.1038/s41592-024-0…
Duderstadt_lab retweeted
We are excited to share new mechanistic insights into DNA replication fidelity! How does human DNA Polymerase Epsilon recognise and proofread errors made during synthesis? 🧬
Read @NatureSMB nature.com/articles/s41594-0…
Cool video of eukaryotic dna replication! #molecularnodes
Here's a render of a full eukaryotic replisome carrying out DNA replication. This was built using real .pdb data from @buildmodels
I used this to make my latest video: (youtu.be/lv89fSt5jBY)
But now I want to do a quick works cited 🧵 (1/ ?)
Duderstadt_lab retweeted
Glad to present our latest results published today in @Nature revealing the activation mechanism of the AAA+-dependent IS21 transposase. Congrats to all the authors!
@CIB_CSIC, @CSIC
Full story here:
rdcu.be/dLZgB
nature.com/articles/s41586-0…
and brief summary below 👇🧵
Duderstadt_lab retweeted
Thank you so much for the warm welcome!😍 It has already been such a stimulating and rewarding experience at @mpi_ie , looking forward to the years ahead!🧑🔬🧫🔬🧬
We are so happy to welcome Valentin Flury (Follow: @ValeFlury) as the newest Group Leader of Max Planck #Freiburg. 🥳
His lab at the @mpi_ie aims to understand #chromatin dynamics and plasticity throughout the cell cycle.
📰INTERVIEW with the #NewPI: ie-freiburg.mpg.de/5849404/2…
Duderstadt_lab retweeted
Now online! Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa dlvr.it/T8BfVZ
Duderstadt_lab retweeted
How does Mcm10 activate an origin of replication?
Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉
rdcu.be/dIdI4
Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick
