@DukeMicrobiome

Cultivating microbiome science @DukeU for human health, the environment, and biotechnology

 Durham, NC
sites.duke.edu/microbiome/
Joined November 2017
  • Tweets291
  • Following223
  • Followers684
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Absorptive cells called lysosome-rich enterocytes (LREs) play a critical but little-known role in neonatal digestion. Through a new @NIH grant, @DukeMedSchool's @RawlsLab and @BagnaLab will investigate the formation and function of LREs and how various stimuli can impact them.
Collage with headshots of John Rawls and Michel Bagnat, as well as NIH and DMC logos.

ALT Collage with headshots of John Rawls and Michel Bagnat, as well as NIH and DMC logos.

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Species abundance has long been the default variable in predicting the functions of microbial communities, but new research from @DukeUBME and published in @CellPressNews could offer a more reusable model that represents species by their genetic features. cell.com/cell-systems/abstra…
Headshot of Ophelia Venturelli, logos of Duke Biomedical Engineering and Duke Microbiome Center, graphic abstract showing data-driven community genotype-function (dCGF) modeling framework, and paper title "A data-driven modeling framework for mapping genotypes to synthetic microbial community functions"

ALT Headshot of Ophelia Venturelli, logos of Duke Biomedical Engineering and Duke Microbiome Center, graphic abstract showing data-driven community genotype-function (dCGF) modeling framework, and paper title "A data-driven modeling framework for mapping genotypes to synthetic microbial community functions"

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Modifying the intestinal microbiome could treat and even prevent growth faltering in extremely premature infants, according to new research spearheaded by Noelle Younge and published in @jclinicalinvest.
Duke University School of Medicine@DukeMedSchoolSep 16
New research led by @Duke_Childrens' Noelle Younge, MD, MHS, finds evidence that the gut microbiome plays a direct role in growth faltering among extremely preterm infants, opening the door to potential new therapies for vulnerable babies in the NICU. medschool.duke.edu/news/stud…

Study links gut bacteria to poor growth in preterm infants

A team led by Duke neonatologist Noelle Younge, MD, MHS, has found evidence that the intestinal microbiome plays a direct role in slow weight gain and poor growth in preterm infants.

medschool.duke.edu
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Could a sugar molecule produced by a gut bacterium offer a viable alternative to GLP-1s? A new paper in @cellhostmicrobe sheds light on a previously unknown link between the gut microbiome and metabolism.
Duke University School of Medicine@DukeMedSchoolSep 24
Neeraj Surana, MD, PhD, and colleagues identified a previously unknown connection between the gut microbiome and metabolism. Their findings suggest a naturally occurring gut bacterium may help regulate energy expenditure and visceral fat. medschool.duke.edu/news/swee…

A sweet discovery to fight obesity

New research from Duke University School of Medicine points to a surprising possibility: a naturally occurring human gut bacterium produces a sugar molecule that helps obese mice increase energy...

medschool.duke.edu
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Numerous fields study biofilm environments, which can make it difficult to analyze disparate datasets. But, a new paper in @ASMicrobiology from @DukeU Professor @aandrewdjones shows how engineering tools can be applied to microbiology for meta-analysis. journals.asm.org/doi/full/10…

Dimensional analysis as a tool for biofilm comparative analysis: bridging the interdisciplinary...

Bacteria primarily exist in biofilms, comprising ~80% of bacteria outside of the ocean and 20%–80% of the total bacteria on Earth (1). Bacterial biofilms are agglomerations of bacteria, proteins,...

journals.asm.org
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Researchers at @DukeGHI have landed a five-year R01 grant from the @NIH to study Plasmodium falciparum (the single-cell parasite responsible for the most fatal cases of malaria) and how sickle-trait hemoglobin adapt. The ultimate goal? To develop future interventions.
Headshots of Steven M. Taylor and Avi Kenney plus NIH, Duke Global Health Institute, and Duke Microbiome logos.

ALT Headshots of Steven M. Taylor and Avi Kenney plus NIH, Duke Global Health Institute, and Duke Microbiome logos.

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Beauty is skin-deep, but what about aging? A new perspective in @aaas from DMC Director Julia Oh and @jacksonlab's @Jalili_Sasan explores the role of the skin microbiome in healthy aging. science.org/doi/10.1126/scie…

Beyond wrinkles

Can the skin microbiome shape healthy aging?

science.org
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We already know that climate change impacts evolution, but a new study in @RSocPublishing by @DukeU researchers shows how intra- and interspecies interactions, not just abiotic factors, can influence genetic diversity as a response. royalsocietypublishing.org/r…
Image showing the title of the paper, “Ecological interactions mediate evolutionary responses to temperature in microbial communities," a cover photo of The Proceedings of the Royal Society B, headshots of Ewaldo Leitão and Jean-Philippe Gibert, and logos of the Duke Microbiome Center and the Gibert Lab.

ALT Image showing the title of the paper, “Ecological interactions mediate evolutionary responses to temperature in microbial communities," a cover photo of The Proceedings of the Royal Society B, headshots of Ewaldo Leitão and Jean-Philippe Gibert, and logos of the Duke Microbiome Center and the Gibert Lab.

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After more than a decade, John Rawls is stepping down as DMC director. Julia Oh, who served as co-director, has assumed the role. Please join us in thanking John and congratulating Julia! For more on the transition, check out this post from @DukeMedSchool medschool.duke.edu/blog/lead…
Headshots of John Rawls and Julia Oh with Duke Microbiome Center Logo and the following quotes: When I look back on these years, the accomplishments that stand out most are not programs or numbers. They are your accomplishments. — John Rawls Dr. Rawls’ long leadership has been truly exemplary and I pledge to strive to build on this remarkable community that he’s brought together. — Julia Oh

ALT Headshots of John Rawls and Julia Oh with Duke Microbiome Center Logo and the following quotes: When I look back on these years, the accomplishments that stand out most are not programs or numbers. They are your accomplishments. — John Rawls Dr. Rawls’ long leadership has been truly exemplary and I pledge to strive to build on this remarkable community that he’s brought together. — Julia Oh

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A new paper in @MicrobioSoc explores the co-evolution of viruses and hosts. Co-authored by @DukeTrinity's Brian McAdoo, Anne Yoder, and former PhD student @biologelise, the study found unique viruses among Madagascar primates and rodents. microbiologyresearch.org/con…
Collage with cover photo of Microbial Genomics journal, headshots of Anne Yoder, Brian McAdoo, and Elise Paietta, and text of the paper "Mammal-infecting DNA viruses identified in lemurs and rodents in Madagascar mirror the evolutionary history of their hosts"

ALT Collage with cover photo of Microbial Genomics journal, headshots of Anne Yoder, Brian McAdoo, and Elise Paietta, and text of the paper "Mammal-infecting DNA viruses identified in lemurs and rodents in Madagascar mirror the evolutionary history of their hosts"

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Phages could help create environmentally friendly anti-biofouling coatings in marine applications. And with a new grant from @USNavyResearch, @jesethdv, assistant professor of civil and environmental engineering, will investigate that exciting possibility.
Headshot of Dr. Jeseth Delgado Vela and ONR and DMC logos

ALT Headshot of Dr. Jeseth Delgado Vela and ONR and DMC logos

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Ever been trapped in the tedium of analyzing genomic variants across large datasets? WeavePop, a open-source new workflow created by @DukeMGM researchers and available on @github, identifies small variants in eukaryotic haploids #G3journal @GeneticsGSA academic.oup.com/g3journal/a…
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Congrats to @gutbrains in @DukeNeuro and @Duke_GI_ for receiving an @NIH grant for "A gut sense for dietary lysine." This research will explore how the sensory cells of the small intestine detect and potentially prioritize the amino acid lysine.
Collage featuring Diego Bohorquez, images of gut-brain connections, and logos of NIH, Department of Neurobiology, and Duke Microbiome Center

ALT Collage featuring Diego Bohorquez, images of gut-brain connections, and logos of NIH, Department of Neurobiology, and Duke Microbiome Center

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A new paper in @jclinicalinvest, co-authored by @valdi001, shows how pathobiont colonization combined with host susceptibility and specialized immune responses can inflame regions of the colon in Crohn's. These findings could inform geo-targeted therapies jci.org/articles/view/201729
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Historically, the biological effects of microbiome-derived metabolites have been difficult to characterize, but a recent @iScience_CP paper (featuring research from @DukeUBME) presents a new, cutting-edge approach that leverages machine learning. cell.com/iscience/fulltext/S…

Profiling biological effects of microbiome metabolites via machine learning

Microbiome; Machine learning

cell.com
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We're onto Translational Microbiome Research: One standout presentation is from Dr. Mara Serbanescu with @Duke_Anesthesia, who is investigating how the prevalence of gut-derived microbes in the bloodstream can correlate with ICU stay duration #NCMicrobiomeSymposium
Dr. Mara Serbanescu presents at the NC Microbiome Symposium.

ALT Dr. Mara Serbanescu presents at the NC Microbiome Symposium.

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Today is the #NCMicrobiomeSymposium, hosted by @ncbiotech! The event kicked off with multiple talks on Microbiome Methodological Advances, including DMC member Dr. Shuo Han whose lab is identifying new gut bacteria that impact lifespan. thehanlab.com/
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Tagging @theHanLab!
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Microbial communities play a crucial role in shaping environments, but how can we predict their behavior? Dr. Ophelia Venturelli in @DukeUBME is investigating the potential of machine learning in this context venturellilab.org/ #NCMicrobiomeSymposium
Dr. Ophelia Venturelli presents at the NC Microbiome Symposium

ALT Dr. Ophelia Venturelli presents at the NC Microbiome Symposium

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Congrats to Noelle Younge (Associate Professor of Pediatrics, @DukeMedSchool) who was recently awarded a five-year @NIH grant, "Mechanisms of microbial regulation of postnatal growth and lipid metabolism."
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