@DylanLSchaff

@pennbioeng PhD student working with @sydshaffer to study how transcriptional heterogeneity leads to treatment resistance in melanoma

 Charlottesville, VA
Joined March 2019
  • Tweets106
  • Following218
  • Followers181
7Media
Very excited to share the @biorxivpreprint of my first, first-author paper of grad school with my amazing former undergrad and co-first author Aria Fasse! biorxiv.org/content/10.1101/…

Clonal differences underlie variable responses to sequential and prolonged treatment

Cancer cells exhibit dramatic differences in gene expression at the single-cell level which can predict whether they become resistant to treatment. Treatment perpetuates this heterogeneity, resulting...

biorxiv.org
3
20
2
59
26,415
Excited to share this work in its final form! sciencedirect.com/science/ar… @CellSystemsCP
Dylan Schaff@DylanLSchaff28 Mar 2023
Very excited to share the @biorxivpreprint of my first, first-author paper of grad school with my amazing former undergrad and co-first author Aria Fasse! biorxiv.org/content/10.1101/…

Clonal differences underlie variable responses to sequential and prolonged treatment

Cancer cells exhibit dramatic differences in gene expression at the single-cell level which can predict whether they become resistant to treatment. Treatment perpetuates this heterogeneity, resulting...

biorxiv.org
4
6
21
6,683
Single Cell Analysis 2024 | @CSHL @cshlcourses Deadline: 3/5/24 Course: 6/27-7/13 @mikemc43, Julea Vlassakis, Huaiying Zhang, @nicholas_navin, Sanja Vickovic, @Mandovi_C ⁦@DylanLSchaff⁩ + top legendary lecturers! meetings.cshl.edu/courses.as…

Single Cell Analysis

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu
1
13
1
47
10,659
Some fun happening at ⁦@cshlmeetings⁩ 2023 Single Cell Analysis Course ⁦@10xGenomics⁩ #nocellleftbehind #fixmeacell
2
35
3,148
I'm excited to share our new @biorxivpreprint! We found that individual epithelial cells grow to dramatically different sizes within a fixed time. This variability in proliferative capacity is governed by both cell-intrinsic and cell-extrinsic factors. 1/n biorxiv.org/content/10.1101/…

Non-genetic differences underlie variability in proliferation among esophageal epithelial clones

The growth potential of individual epithelial cells is a key determinant of tissue development, homeostasis, and disease progression. Although it is known that epithelial progenitor cells vary in...

biorxiv.org
2
24
5
69
20,743
Finally, we show that gene expression states can predict which clones will survive or die during future treatment.
1
4
423
This work would not have been possible without Phoebe White, @RobertVanderVe1, and @sydshaffer !!!
1
2
362
Dylan Schaff retweeted
bioRxiv@biorxivpreprint25 Mar 2023
Clonal differences underlie variable responses to sequential and prolonged treatment biorxiv.org/cgi/content/shor… #bioRxiv
1
2
2,774
Clonal differences underlie variable responses to sequential and prolonged treatment biorxiv.org/cgi/content/shor… #biorxiv_sysbio
1
388
Dylan Schaff retweeted
Mike McConnell@mikemc4313 Mar 2023
Apps Due NOW!!! Cold Spring Harbor Single Cell Analysis meetings.cshl.edu/courses.as… Check out the speakers and module leaders, I don't know when I've been this stoked in March before.

Single Cell Analysis

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu
12
1
18
6,762
Check out this awesome work from one of my lab mates on evolution of cancer from Barrett’s esophagus!
Sydney Shaffer@sydshaffer2 Feb 2023
Excited to share our latest preprint led by Rodrigo Gier!!🥳🥳 with @HuerosRaul and amazing collaborators @NancyZh60672287 @DrGaryFalk @LabMuir @tkarakasheva Lineage tracing with scRNA-seq to track the origins of metaplasia and its evolution to cancer. biorxiv.org/content/10.1101/…

Clonal cell states link Barrett’s esophagus and esophageal adenocarcinoma

Barrett’s esophagus is a common type of metaplasia and a precursor of esophageal adenocarcinoma. However, the cell states and lineage connections underlying the origin, maintenance, and progression...

biorxiv.org
1
4
571
Look at that line up of Speakers and Module Leaders! Fun fun fun 🤩 Have you applied yet? – at Adelaide, South Australia
7
39
5,505
Single Cell Analysis 2023 | CSHL Two weeks packed with amazing speakers, hands-on experiments and data analysis, brainstorming walks, laughs, long-lasting friendships, volleyball, ‘office hours’, more laughs in the memory making paradise of ⁦@CSHL⁩ meetings.cshl.edu/courses.as…

Single Cell Analysis

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu
15
51
7,746
Ping: @HMS_SCC @afvallejop @ioavlachos @DrJasPlummer @DylanLSchaff @PeterMacCC @WEHI_research @SAiGENCI @GarvanInstitute @singlecellworld @UTSEngage @FaValdesMora @CytoNology @dgallegoortega @TimJSemple @m_mohenska Please RT fellas!
Luciano Martelotto 🛠🧬💻🇦🇺@LGMartelotto19 Jan 2023
Registrations are open to the CSHL Single Cell Analysis 2023 Amazing 2-weeks bootcamp that you can’t miss. Appl. due March 15. ⁦Brought to you by Mike (@mikemc43⁩), Dave, Jules and your truly 😅 ⁦⁦@cshlcourses⁩ ⁦@UniofAdelaide⁩ meetings.cshl.edu/courses.as…

Single Cell Analysis

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

meetings.cshl.edu
1
7
1
10
2,486
Load more