A pioneer and leader in commercialized products & services for #epigenetic research including assay kits, antibodies, proteins, peptides, & various reagents.
Farmingdale, NY
Joined September 2009
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A little Halloween throwback from the EpigenTek archives! 🎃
#Halloween #LabLife
youtube.com/watch?v=5yi7NyOz…
Bivalent chromatin in cancer: lineage switching, selection, or both? Bulk profiles alone can't tell. H3K4me3/H3K27me3 peak overlap doesn't prove nucleosomal bivalency.
Read more: epigentek.com/catalog/bivale…
Starting a new lab, moving to a new institution, or working with your first research grant?
Get your lab up and running with more of your budget available for the research ahead.
#NewLab #ResearchLab #Epigenetics #LifeScience
Methylation, ATAC-seq, and RNA-seq don't always align. Before drawing regulatory conclusions, consider CpG coverage, cell composition, and the 5-mC/5-hmC ambiguity in conventional bisulfite data.
Learn more: epigentek.com/catalog/bisulf…
The EpiNext CUT&LUNCH Assay Kit offers a rapid, streamlined 3-step workflow for profiling protein-DNA interactions in low-input cell and tissue samples.
Product details: epigentek.com/catalog/epinex…
#Epigenetics #NGS #MolecularBiology
Clean, reproducible chromatin profiles can still reflect method bias.
See how CUT&RUN, CUT&Tag, ChIP-seq, and CUT&LUNCH differ in accessibility effects, target context, and the controls needed to interpret their signals.
epigentek.com/catalog/method…
What can cfDNA tell us that sequence alone cannot?
Methylation patterns, fragment length and end motifs, and nucleosome-associated fragmentation can provide complementary signals for tissue-of-origin, cell-type, and chromatin-accessibility inference.
#cfDNA #Epigenetics #Fragmentomics
Affinity alone does not tell you whether an antibody will resolve the molecular state your assay actually needs. For conserved proteins, limited epitopes, and PTM-specific targets, the screening contrasts are what determine useful specificity.
Check out the full article below epigentek.com/catalog/recomb…
Incredible work from @jpoganik, @gladyshev_lab, and colleagues at Brigham and Women's Hospital and Harvard Medical School.
These findings raise a fascinating question for the biology of aging: how much of an organ's biological age is tissue-intrinsic, and how much is imposed by the systemic environment?
The mechanistic question is especially interesting: which systemic factors are capable of remodeling the epigenetic and transcriptional state of an aged tissue?
#Epigenetics #Aging
biorxiv.org/content/10.64898…
Compare CRISPR conditions with more confidence by verifying Cas9/dCas9 protein abundance before moving to locus-specific readouts.
Explore EpigenTek antibodies and quantitative assay kits: epigentek.com/catalog/crispr…
#CRISPR #Cas9 #GenomeEditing #MolecularBiology
🤖 Made with AI
A change in METTL3 or FTO does not, by itself, establish an m6A mechanism. This review looks at how transcript-level evidence and assay resolution can strengthen mechanistic claims in m6A studies.
Learn More: epigentek.com/catalog/m6a-wr…
An interesting glimpse into the future of biological research. AI-assisted analysis helped identify a previously uncharacterized enzyme system with CRISPR-like repeats, with scientists taking the findings into the lab for further investigation.
Exciting to see computational discovery and experimental biology coming together.
#Genomics #MolecularBiology #AIinScience
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.
We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.
Read more: anthropic.com/news/claude-di…
For researchers working with established CRISPR/Cas9 systems, EpigenTek offers ELISA kits for quantitative Cas9 and SaCas9 measurement, plus monoclonal antibodies for ELISA, IF, IP, and WB.
Explore our CRISPR research tools:
epigentek.com/catalog/crispr…
Introducing our new SpeedRun One-Hour ELISA Kits, designed for a faster, streamlined ELISA workflow across multiple targets.
Save $50 on all SpeedRun kits through December 31, 2026.
Learn more: epigentek.com/catalog/one-ho…
How portable is antibody validation across chromatin profiling assays? Strong ChIP performance may not predict CUT&Tag behavior when epitope accessibility and productive Tn5 tethering differ.
Learn More: epigentek.com/catalog/antibo…
The MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit offers a fast, sensitive, colorimetric workflow for quantifying 5-mC across a wide range of DNA samples.
#DNAMethylation #5mC #Epigenetics #ELISA #MolecularBiology
RRBS can be a practical fit for FFPE and other limited samples when the goal is reproducible coverage of CpG-rich regions. The key constraint is often library complexity and shared CpG coverage across samples, not DNA concentration or read count alone.
epigentek.com/catalog/rrbs-f…
