physician-scientist, author of SUPER AGERS https://xitter.cf/t.co/ZEdooyyJpP and Ground Truths: https://xitter.cf/t.co/YhatcBT0hA
La Jolla, CA
Joined November 2009
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A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon.
amazon.com/gp/new-releases/b…
Eric Topol retweeted
This is a remarkable story @RadicalNumerics and a real use case of how AI can be used for new treatments.
Quite a lede
"For the first time, scientists say they have used viruses designed by AI to treat a human patient."
Front page @nytimes
gift link nytimes.com/2026/10/20/scien…
It's great to see tech leaders investing, philanthropically supporting biomedical science. Editorial and Feature @Nature re: upside and some concerns
nature.com/articles/d41586-0…
nature.com/articles/d41586-0…
Just published @Nature
A 3-agent AI personal health agent exceeded performance of a large language model/chatbot and serves as a foundation to build on for integrating sensor data, medical knowledge and coaching
nature.com/articles/s41586-0…
Accompanying @NatureNV pointing out the next big step would be to do a RCT for health outcomes nature.com/articles/d41586-0… by @2plus2make5
Quite a lede
"For the first time, scientists say they have used viruses designed by AI to treat a human patient."
Front page @nytimes
gift link nytimes.com/2026/10/20/scien…
Details of the phage therapy for antimicrobial resistance
@RadicalNumerics (from their website)
radicalnumerics.ai/blog/omni…
New @Cell_Metabolism on benefit of intermittent fasting in overweight individuals with metabolic syndrome
A randomized trial showed that the Mediterranean diet, while reducing lipid abnormalities, did not suppress inflammation until intermittent fasting was added
cell.com/cell-metabolism/ful…
My @scrippsresearch colleague @xinjin and her team are doing amazing brain biology discovery work with 2,000 agents, PerturbAI, in collaboration with @OpenAI
prnewswire.com/news-releases…
White blood cell biology links to health and disease
insights on neutrophil-specific signatures and health outcomes. Plus
"In two independent EHR databases, absolute neutrophil counts within clinically normal range were associated with subsequent development of
multiple comorbidities and increased mortality."
nature.com/articles/s41590-0…
Retatrutide, the most potent GLP-1 agent in this family of drugs to date, had a marked benefit vs sleep apnea in a randomized trial, in people with obesity, just published @NEJM AHI-apnea-hypopnea index
nejm.org/doi/full/10.1056/NE…
National recall of GLP-1 drug (tirzepatide) made by a US compounding pharmacy because it puts patients at risk, according to FDA
usatoday.com/story/money/con…
GLP-1 peptides protect the gut from immune injury.
Essential role of endogenous GLP-1 family peptides to reduce inflammation and restore mucosal integrity in the experimental model @DanielJDrucker @CellRepMed
cell.com/cell-reports-medici…
There's a lot in a face photograph about health that AI can detect, as seen in this foundation model of >40 million face images, including outcomes from cancer, biological age, influence of lifestyle factors, and survival @LancetDigitalH
thelancet.com/journals/landi…
An assessment of AI LLMs for overuse or inappropriate restraint of testing vs established Choosing Wisely recommendations
—AI overuse 5.4%, mainly due to ECGs and thyroid imaging
—AI restraint deemed incorrect rate 0.6%
acpjournals.org/doi/10.7326/… @AnnalsofIM
Eric Topol retweeted
Scripps Research today received 14M+ compute hours from the Jen-Hsun and Lori Huang Foundation. Led by @WardLab1, the grant also supports @bryanbriney and @ForliLab on a virtual human immune system and the “dark” proteome, with data from @_chrisgparker_ and Benjamin Cravatt.
More: ow.ly/gOzA50ZZ2iJ
"Our study reveals an interesting aging effect that complicates the prevailing narrative of declining innovation over a scientific career."
More persistent disruptive (PD) work by senior scientists than younger counterparts
pnas.org/doi/10.1073/pnas.26…
