@FKH_Lab

Professor of Pharmaceutical Chemistry at University of Bonn, Germany. Vice speaker of @GRK2873.

 Bonn, Deutschland
pharma.uni-bonn.de/www/pharmchem2/ak-hansen-en?set_language=en
Joined March 2018
  • Tweets565
  • Following393
  • Followers593
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Finn K. Hansen retweeted
Guillaume Laconde@Glaconde34Jan 2
Discovery of Histone Deacetylase 8-Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

Discovery of Histone Deacetylase 8‑Specific Proteolysis-Targeting Chimeras with Anticancer Activity...

Abstract. Histone deacetylase 8 (HDAC8) has emerged as promising therapeutic target for several malignancies. In this study, we developed two series of cer

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Enhancing Solubility in VHL-Based PROTACs: Optimized USP7 Degraders for Improved Developability | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…
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Thrilled to see Our FerroTac story is now out at @J_A_C_S - Huge congrats 🙌🏻 🥳 @ales_salerno Lianne and Claudia! @UoDCeTPD
J. Am. Chem. Soc.@J_A_C_S10 Apr 2025
Rational Design of PROTAC Linkers Featuring Ferrocene as a Molecular Hinge to Enable Dynamic Conformational Changes | Journal of the American Chemical Society @alessiociulli @Dundeeuni @UoDCeTPD. @AmphistaThera pubs.acs.org/doi/10.1021/jac…

Rational Design of PROTAC Linkers Featuring Ferrocene as a Molecular Hinge to Enable Dynamic...

Abstract. Proteolysis Targeting Chimeras (PROTACs) are bifunctional molecules that induce ubiquitination and degradation of a target protein via recruitmen

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#ChemMedChem Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan-Degrader (Finn K. Hansen and co-workers) #openaccess 🔓 onlinelibrary.wiley.com/doi/…

Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a...

This study introduced DCAF11 as an E3 ligase for PROTAC-mediated histone deacetylase (HDAC) degradation. By replacing cereblon with DCAF11 as recruited E3 ligase, a selective HDAC6 degrader (A6) was...

chemistry-europe.onlinelibrary.wiley.com
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I stood in line for 3 hours to vote today! 🇺🇸 It’s a small price to pay for democracy and our right to have a voice. Voting is more than a duty; it’s a privilege. Let’s participate, make our voices heard, and respect the outcome, whatever it may be.
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#ChemMedChem #OnTheCover A NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6, CXCR1 (Matthias Schiedel and co-workers) onlinelibrary.wiley.com/doi/… @FKH_Lab @MatthiasSchied2 onlinelibrary.wiley.com/doi/…
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Finn K. Hansen retweeted
Oded Rechavi
@OdedRechavi17 Oct 2024
PhD student: "please don't be excited yet, these are just preliminary results, I still need to repeat the experiment multiple times" PI:
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Finn K. Hansen retweeted
Ingo Hartung@HartungIngo25 Sep 2024
We have 2 exciting postdoc openings in our Medicinal Chemistry Drug Design department @merckgroup: for our collaboration with @LabThoma @EPFL_en (molecular glue degrader identification); for @proxidrugs w/ @Hausch_lab & Stefan Knapp (novel E3 for #PROTACs) linkedin.com/jobs/view/40347…
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Congrats to postdoc Juana Goulart Stollmaier @jubsnjubs and group alum Dr @ParisRWatson for this fantastic work, just published in ACS Med Chem Lett @ACSBioMed! HDAC10 catalyzes thioester hydrolysis to activate thiol-containing pharmacophores. pubs.acs.org/doi/10.1021/acs…

Design, Synthesis, and Structural Evaluation of Acetylated Phenylthioketone Inhibitors of HDAC10

Abstract. Histone deacetylase 10 (HDAC10) is unique among the greater HDAC family due to its unusually narrow substrate specificity as a polyamine deacetyl

pubs.acs.org
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Finn K. Hansen retweeted
ChemMedChem@ChemMedChem2 Sep 2024
If you're at #EFMCISMC24, visit the @ChemEurope table at EFMC Booth #59. Get some @Wiley_Chemistry book discounts, writing guides & freebies and meet our EiC! Then visit the @YoungSciNet Photo Booth to our left & chat with some YSN volunteers! @EuroMedChem #medchem #chembio
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Do you want to target Methyl-Transferase-Like proteins ? Keep calm and... count to 16!!! #SPOTSLab @DeptPharm_Unina pubs.acs.org/doi/10.1021/acs…
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We are looking for a Scientist to join us in the Fischer lab to work on proteomics-based projects. If you are interested in big data problems and using proteomics as a research tool take a look at the job description and apply now! careers.dana-farber.org/job/…
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Finn K. Hansen retweeted
ChemMedChem@ChemMedChem2 Aug 2024
Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1 (F. K. Hansen, M. Schiedel et al.) @FKH_Lab, @MatthiasSchied2 #openaccess onlinelibrary.wiley.com/doi/…

Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Recept...

Our newly developed NanoBRET assay platform allows the detection of intracellular ligand binding to CCR6 and CXCR1, enables equilibrium as well as kinetic binding studies in a cell-free and cellular...

chemistry-europe.onlinelibrary.wiley.com
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Finn K. Hansen retweeted
Oded Rechavi
@OdedRechavi18 Jul 2024
We thank the reviewers for their helpful suggestion xitter.cf/SpellOdyssey/status/18…
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Finn K. Hansen retweeted
OnsOranje
@OnsOranje10 Jul 2024
DORTMUND! ⬅️😍➡️ #NothingLikeOranje #NEDENG
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Finn K. Hansen retweeted
Mio@161mio11 Jul 2024
Der Saxophon Mann hat Seiten gewechselt
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Postdoc in Medicinal Chemistry & Molecular Glue discovery wanted! Combine advanced organic chemistry & cutting edge drug discovery in a vibrant, international team? Further infos: chemie.tu-darmstadt.de/hausc…
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🙌 RESPECT: The Spanish players lined up to greet Toni Kroos one by one, as he played his final professional match today ❤️ #EURo2024
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Danke für alles ❤️
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Finn K. Hansen retweeted
Bayern & Germany
@iMiaSanMia5 Jul 2024
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