Max-Planck Research Group at MPI for Multidisciplinary Science (@mpi_nat) | Autophagy initiation | Structural biochemistry | Reconstitution | Views are my own.
Göttingen
Joined August 2018
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It is also time to say goodbye to Germany. You have giving me and my family a lifetime full of memories.
So, what's next? Time will tell…
For now… auf Wiedersehen.
Tschüss!
I am grateful to the organisations and to all my colleagues for their support and collaboration, stimulating scientific discussions, and the opportunity to work at the cutting edge of science. A truly formative experience.
It still feels a bit unreal to leave after such a long time. The quality of science I have observed, the lessons learned and experiences gained, they all have shaped me in many ways and will remain an important part of my journey.
After 14 years in the @maxplanckpress Max-Planck Society, it has come time to say goodbye. What started as a postdoc in Andrea Musacchio’s lab at the @mpimoph MPI-MP, continued on new topics as an independent Max-Planck Research Group Leader at the @mpi_nat MPI-NAT.
Thanks to all the authors for their hard work! This work was done by @mpi_nat. We thank @CompBioPhys and Urlaub laboratory for their help, and @dfg_public and @maxplanckpress for funding. Check it out for many more surprises!
Feedforward auto-activation: activated ATG101 subsequently quickly activates non-activated ATG101 molecules to create a positive feedforward reaction and supports the local fast assembly of a key complex in autophagy initiation.
Memory of activation: hysteresis causes ATG101 to ‘remember’ its activation for many hours after dephosphorylation due to the very slow, but spontaneous back-conversion to the default fold.
Auto-activation: this work proposes an unusual regulatory mechanism where UKL1 kinase initiates an ATG101 auto activation cascade. ULK1 kinase activity dramatically accelerates an extremely slow assembly upon aiding a change in the fold of ATG101.
In this manuscript, we revisit the question “how is autophagy initiated at the right place and time?”. What started as a relatively straightforward search for the rate-limiting regulatory step, resulted in the discovery of a unique mechanism of regulated protein metamorphosis.
This was a wild ride!
biorxiv.org/content/10.1101/…
see thread below 🧵👇
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FaesenLab retweeted
Influence of ULK1 activity on the memory of ATG101 auto-activation dynamics biorxiv.org/content/10.1101/… #biorxiv_biochem
FaesenLab retweeted
Influence of ULK1 activity on the memory of ATG101 auto-activation dynamics
biorxiv.org/content/10.1101/…
Waiting for you @StorkLab in spectacular Sorrento... I've had worse views while reading literature in preparation. #EMBOautophagy24
Do not forget to apply!
PhD or postdoc position in biochemistry, biophysics & structural biology @FaesenLab! Join the project focusing on the reconstitution and structural-functional characterization of newly identified and purified macromolecular super-complexes. 👇
mpinat.mpg.de/4787445/27-24
FaesenLab retweeted
Place to be for scientists studying quality control mechanisms in life processes. Impressive line-up of speakers. Thx to @HMWK_Hessen @EnableFrankfurt and @dfg_public @SFB1177.
Students and postdocs are invited to apply for selected talks👍🤗
@goetheuni #ubiquitin #autophagy
#FCQC2025: Registration open fcqc.de/
Join us for a high-caliber line-up of talks on quality control mechanisms & networks, the interplay of autophagy & ubiquitin in health & disease, novel therapeutics using the ubiquitin system.
#proteostasis #autophagy
FaesenLab retweeted
PhD or postdoc position in biochemistry, biophysics & structural biology @FaesenLab! Join the project focusing on the reconstitution and structural-functional characterization of newly identified and purified macromolecular super-complexes. 👇
mpinat.mpg.de/4787445/27-24
Link for ad: mpinat.mpg.de/27-24?c=250103…
We are recruiting new labmembers @mpi_nat for DFG funded projects!
#Biochemistry, #biophysics and #structuralbiology on metamorphic proteins and new autophagy initiation super-complexes. #PhDposition #Postdocposition #proteins #sciencejobs
Details: mpinat.mpg.de/4787445/27-24
We are recruiting new labmembers @mpi_nat for DFG funded projects!
#Biochemistry, #biophysics and #structuralbiology on metamorphic proteins and new autophagy initiation super-complexes. #PhDposition #Postdocposition #proteins #sciencejobs
Details: mpinat.mpg.de/4787445/27-24
FaesenLab retweeted
#PhD, #DnD(?) & #postdoc positions in “theory and methods for non-equilibrium atomistic simulations of complex #biomolecules” – Interested in theoretical and computational #biophysics? Check out the #JobAlert & apply here ⬇️: Shares welcome! #hiring #job
mpinat.mpg.de/4588467/60-23?…