@FraternaliLab

Bioinformatics & Computational Biology @ University College London @ISMBInstitute @ucl

 London, England
fraternalilab.github.io
Joined March 2018
  • Tweets129
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  • Followers176
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Dongjun & Joseph at #bsi2025 with poster on this! Poster P005
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Also check out UCL press release: ucl.ac.uk/life-sciences/news…

ImmunoMatch AI predicts accurate antibody chain pairing, accelerating therapeutic discovery |...

A UCL-led team has developed an AI tool to understand antibody assembly in the human body, speeding therapeutic antibody design and revealing new insights into B-cell maturation and immune responses.

ucl.ac.uk
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Belated announcement that ImmunoMatch has now been published in @naturemethods !🎉 AI powered prediction of antibody heavy-light chain pairing with applications in understanding B cell biology and mAb discovery. nature.com/articles/s41592-0…

ImmunoMatch learns and predicts cognate pairing of heavy and light immunoglobulin chains

Nature Methods - ImmunoMatch is a machine-learning framework that learns from heavy and light immunoglobulin chains to predict cognate sequence pairings.

nature.com
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Replying to @FraternaliLab @ffrancafrat
@3DSIG_ISCB @iscb
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Replying to @ffrancafrat
@ffrancafrat to deliver keynote in the #3DSIG track #ISMBECCB2025 In Liverpool this year! linkedin.com/posts/rgonzalop…

We are really happy to have Prof. Franca Fraternali as one of our Keynote speakers this year at...

We are really happy to have Prof. Franca Fraternali as one of our Keynote speakers this year at 3DSIG/ISMB in Liverpool! Prof. Fraternali will present cutting-edge AI and structure-based strategies...

linkedin.com
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Great talks by both Oriol and Joseph at #ELIXIR #3dBioinfo meeting at Barcelona!
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Fraternali Lab retweeted
Josef Ng@JosefNg117 Mar 2025
Another preprint @FraternaliLab: We explored how the antibody framework (i.e. parts of variable region away from Ab-Ag interface) can be exploited to fine-tune antibody effector functions. V enjoyable in vitro/in silico collab @ffrancafrat @SophiaKaragiann biorxiv.org/content/10.1101/…
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🚨 New preprint on our new approach (IndeLLM) to score pathogenicity of insertions/deletions biorxiv.org/content/10.1101/…

Leveraging protein language models and scoring function for Indel characterisation and transfer...

Protein language models (PLMs) are increasingly used to assess the impact of genetic variation on proteins. By leveraging sequence information alone, PLMs achieve high performance and accuracy and...

biorxiv.org
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Fraternali Lab retweeted
Josef Ng@JosefNg112 Mar 2025
Happy to share new work @FraternaliLab led by @Dongjun_Guo - exploring how antibody heavy and light chains form specific pairs. We fine-tuned an antibody language model to predict pairing, and asked how pairing propensities change during B cell maturation and in diseases.
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Proud to be part of this exceptional mentoring programme💪 @ELIXIREurope
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Replying to @ffrancafrat
@ffrancafrat speaking in Copenhagen today about ongoing work on antibodies in the group!
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Joseph on sciCSR to study and infer class switching dynamics in B cells using scRNA-seq data #ISMB2024
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Dongjun's talk on ImmunoMatch a.k.a. antibody "tinder" to study heavy and light chain pairing at 3DSIG! #ISMB2024
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Oriol's talk on addressing biases in variant impact prediction at VarI #ISMB2024
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Fraternali Lab retweeted
Mauri Lab UCL@Mauri_group18 Jun 2024
Congratulations to Guillem for winning a prize for his poster on double negative/atypical memory B cells in SARS-CoV-2 mRNA vaccination at the @iit_ucl symposium 2024 🎉👏
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Fraternali Lab retweeted
Josef Ng@JosefNg110 Jun 2024
We present VCAb, a new web interface for performing different structure-based explorations towards aspects of antibody engineering: 🧵(1/7) 📄biorxiv.org/content/10.1101/… 🌐fraternalilab.cs.ucl.ac.uk/V…
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Postdoc available in our lab. B cells, antibodies and class switching. Part of a wider BBSRC sLoLa with @FraternaliLab @Mauri_group jobs.surrey.ac.uk/Vacancy.as…

Job Vacancy at the University of Surrey: Research Fellow in Immunology

Applications are invited for the post of Research Fellow based in the School of Biosciences and Medicine under the supervision of Professor Deborah Dunn-WaltersAn exciting opportunity to join our...

jobs.surrey.ac.uk
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Fraternali Lab retweeted
Mauri Lab UCL@Mauri_group14 Mar 2024
Well done to Izzy for winning a prize for her presentation on the single cell analysis of B cells in lung cancer!!👏🫁🧬#WIRM – at Davos, Switzerland
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Xmas gift 🎁 came early for us: New review came out on @COSB_CRSB where we talked about structures of different antibody isotypes & how to model and study them! Feat. a great deal of fun drawing antibodies in the style of ladders and snakes! Free access at authors.elsevier.com/c/1iHZn…
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Xmas outing feat. a walk across Hertfordshire countryside on a cold wintery day followed by pub! – at Hitchin, England
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