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Updated preprint up - direct supplementation with the metabolic cofactor Coenzyme A reverses macrophage immunosuppression + promotes pro-inflammatory & anti-microbial macrophage phenotypes via positive influence on CoA-dependent glucose metabolism (1/x) biorxiv.org/content/10.1101/… – at Berkeley, CA
Greg Timblin retweeted
A CD4-lineage erythro–myeloid progenitor within the adult bone marrow defines an alternative pathway for macrophage generation @NatImmunol
@Shwetatikoo29 @MedUni_Wien @CentenaryInst nature.com/articles/s41590-0…
Greg Timblin retweeted
Frank Gagliano was a college quarterback.
After his career, he was hired to start a football team at a high school. While waiting, he coached track. They never started the football team.
Gags went on to become one of the greatest American distance coaches in history: 15 Olympians, 140 All-Americans, 43 sub-4 milers.
He passed away this week.
We often think that you've got to have done it or experienced it to coach it. Gags was never a runner. He just wanted to coach, the true essence of the word, helping people out.
“I don’t have golf clubs. I have a stopwatch." And like the best 'old school' coaches, he'd help whoever showed up.
I was a former high school phenom, struggling in college. Then I got a call from an unknown number.
"Steve. We've never met. It's Gags with the Farm Team. I just wanted you to know that you're great. Talent doesn't go away. Stick with it. You've got people who believe in you. If I can ever help, let me know."
He called a struggling 19-year-old out of nowhere, while running the best professional team in the country.
In an era where training got really complicated, Gags kept it simple. His philosophy was strength + speed, consistently for a long freaking time.
“Everyone has to be patient in development. Everyone has to enjoy the sport, have a lot of fun, and work really hard.”
More than the workouts, his real secret was the one every great coach shares. Relationships. His son Ralph put it best:
“As a track coach, you have very large teams, many participants, and he carried over the years very special relationships — not only with the great ones, but even with the ordinary athlete.”
He was still coaching into his late 80s.
“As long as my mind is in the sport for workouts, so I don’t deprive the men and women that I’m coaching, I’ll keep coaching.”
And this summer, at 89, when they named a national championship race after him, “I’m not a cocky man. I’m the guy that just coaches, and the athletes mean everything to me, everything.”
He was a coach’s coach. Someone who lost his first meet 112 to 15, and then went on to become an all-time great...despite never having run.
Because the point was to help people....even those he didn't coach.
RIP Gags.
Greg Timblin retweeted
Thrilled to share our latest publication in @NatureComms !
Can the intestine remember a previous injury?
We show that intestinal injury leaves a lasting transcriptional and epigenetic imprint that primes the tissue for enhanced regeneration.
nature.com/articles/s41467-0…
Greg Timblin retweeted
Researchers investigated the impact of TET2-driven clonal hematopoiesis of indeterminate potential on inflammatory bone loss and identified inflammatory bone loss associated with increased tissue infiltration of neutrophils, monocytes, and Th17cells. ow.ly/V2QS5101sKt.

ALT Cell population alterations in the gingiva and systemic tissues in TET2-driven CHIP. Lethally irradiated CD45.1 mice were transplanted with either 10% Tet2–/– CD45.2 BM cells and 90% WT CD45.1 BM cells (“10% Tet2–/– BMT” group) or with 10% Tet2+/+ CD45.2 BM cells and 90% WT CD45.1 cells (“10% Tet2+/+ BMT” group).
COOPER FLAGG STUFFED THE STAT SHEET!
🏀 29 PTS
🏀 6 REB
🏀 11 AST
🏀 5 STL (CAREER-HIGH)
🏀 3 BLK
🏀 MAVS ROAD WIN
Flagg (19 years, 309 days) becomes the first teenager in NBA history to record 25+ PTS, 10+ AST, 5+ REB, and 5+ STL in a single game 🤯
Greg Timblin retweeted
Pleasure to write this News & Views on this elegant work from the Belousov lab, which engineers a chemigenetic bypass of mitochondrial pyruvate uptake. A truly creative advance that expands the experimental toolkit for studying mitochondrial metabolism.
rdcu.be/2ggNASE7YxWa
Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells
nature.com/articles/s41589-0…
Greg Timblin retweeted
CD36 complexity: In humans, loss-of-function increases risk for cardiomyopathy. However, in the present murine ischemia-reperfusion injury model, CD36 suppression improves cardiac function highlighting potential contextual difference in chronic vs acute reactive myocardial fatty acid uptake nature.com/articles/s41467-0… @NatureComms
Greg Timblin retweeted
Now online! Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages dlvr.it/TW3Xtk
Greg Timblin retweeted
Today I'm posting a new video to my YouTube Channel. Persistent misnaming of 17-OHPC as "progesterone" in medical literature lead to pregnant women receiving the wrong drug through compounding pharmacies: youtu.be/I1C9aDfLH-U
Greg Timblin retweeted
Now online! MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss dlvr.it/TW3MXH
Greg Timblin retweeted
You ever just sit in a dark room and feel like the darkness is the only thing that truly understands you. No fake smiles, no false hope. Just raw bitter silence…
Greg Timblin retweeted
Replying to @A_May_MD
This has been the case for years and AI + China is causing it to spike. There will be huge value destruction in modalities like ADCs while VCs fund what's known instead of what's differentiated as if they think their role is to be in the same point in the risk curve as pharma.
If you're in line with a shiny new MoA that is a clear + significant advance over Me Toos but getting overlooked in current climate, just figure out a way to stay in line...it will pay off – at Berkeley, CA
The degree of target clustering in pharma right now is absolute madness. How is this not objectively idiotic?
The pendulum will swing back to unique/novel MoAs eventually…it just has to.
Right now you can get VALIDATED novel/unique MoAs for less than some of these me-80 drugs in some cases. The system seems broken.
Greg Timblin retweeted
Insane; not enough patients for all these TSLP drugs. 😆 I saw there are 79 TSLP candidates but I guess it depends how broad you go and structure.
There are no competitors with my R&D programs, to my knowledge.
Windward Bio, a Swiss startup with Phase 2 drug candidates from a few China-based biotechs, files for a Nasdaq IPO
TSLP and TSLPxIL13 candidates in clinical trials across asthma, COPD + eczema
Novo Holdings, OrbiMed & CEO are largest shareholders
endpoints.news/windward-bio-…






























