The TCF-1-E-protein axis preserves stem-like Th17 identity and prevents autoimmune pathology @CellReports 🇨🇳 cell.com/cell-reports/fullte…

Review @CellRepMed CNS targeted AAV gene therapies: Recent advances and clinical insights cell.com/cell-reports-medici…

Deletion of Ctps1 in T cells prevents GVHD and reduces skin rejection @CellRepMed @Inserm 🇫🇷 cell.com/cell-reports-medici…

Adaptamers, compact RNA switches that use FDA-approved drugs to control gene expression by co-opting endogenous RNA-editing machinery rather than relying on foreign proteins @MolecularCell cell.com/molecular-cell/full… @prashantgmali @UCSD

A multi-omic atlas of human T cell exhaustion reveals broad remodeling of protein turnover & ubiquitin regulation not captured by transcriptomic analysis, w/ RNF166 regulating T cell persistence & function @CellCellPress @sydnyeleighruns @UAMS cell.com/cell/fulltext/S0092…

Computational reconstruction, screening, and engineering of non-LTR retrotransposons uncovers elements, termed Gene Writers, that enable stable transgene integration in human cells using all-RNA delivery @CellCellPress @TesseraTx cell.com/cell/fulltext/S0092…

isoUDCA, a female-enriched bile acid produced by a gut bacterial consortium favored by estrogen, promotes hepatic cholesterol handling and bile acid metabolism through SREBP2-STARD4-CYP7B1 signaling, thereby alleviating chronic liver injury @CellCellPress cell.com/cell/fulltext/S0092…

The pyrin inflammasome senses extracellular ʟ-carnitine through the high-affinity carnitine transporter OCTN2 (SLC22A5) to drive IL-1β-mediated inflammation @CellCellPress @Yale cell.com/cell/fulltext/S0092…

Accessing invasion-competent Plasmodium vivax merozoites reveals antibody-dependent NK cell activation science.org/doi/10.1126/scia… @ScienceAdvances 🇰🇭

BCG vaccination mitigates tau pathology and restores cognitive function in PS19 Alzheimer's mice science.org/doi/10.1126/scia… @ScienceAdvances @HopkinsMedicine

Large-scale longitudinal analysis of posttransplant immune reconstitution reveals how T cell–directed immunosuppression shapes transplant outcomes science.org/doi/10.1126/scit… @ScienceTM @dewolf_susan @MSKCancerCenter @KeanMD @BostonChildrens

Excess IL-18 drives fatal mousepox cytokine storm via NK cell immunodeficiency and nonspecific T-cell hyperactivation @JCI_insight @canna_lab @varghese_jemy @ChildrensPhila insight.jci.org/articles/vie…

Vaccines targeting the inflammasome protein ASC reduce inflammation and downstream pathology in multiple disease models @JCI_insight @UNM insight.jci.org/articles/vie…

Defective Vδ2+ T cell metabolic and functional responses in obesity are reversed with bariatric surgery @JCI_insight @MaynoothUni insight.jci.org/articles/vie…

Endothelial neo-antigen expression initiates CD8⁺ T cell–driven CNS vasculitis amplified by peripheral immune challenge @jclinicalinvest 🇩🇪 jci.org/articles/view/205723

Adjuvanted naked mRNA jet-injection vaccine represents an effective, and safe dermal platform against respiratory viruses @jclinicalinvest jci.org/articles/view/204021 🇯🇵

FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice @jclinicalinvest @Penn jci.org/articles/view/210355

NKG2C+ NK cell-like TCRαβ+ CD8 T cells exhibit effective antitumor control in mice while mitigating cytokine release syndrome @jclinicalinvest @KathyHsuLab @MSKCancerCenter jci.org/articles/view/193053

SKAP2 is a genetically regulated modulator of T cell function whose expression and activity control the balance between adhesion and migration @JExpMed 🇮🇹 rupress.org/jem/article/223/…