Pre-publication manuscripts for genome-wide association studies. By @wpgilks Also see @genomic_pred and @Mendelian_lit #GWAS #genetics #genomics #medicine
East Sussex, England
Joined July 2015
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A model for co-occurrent assortative mating and vertical cultural transmission and its impact on measures of genetic associations biorxiv.org/content/10.1101/…
isGWAS: ultra-high-throughput, scalable and equitable inference of genetic associations with disease biorxiv.org/content/10.1101/…
GxE PRS: Genotype-environment interaction in polygenic risk score models for quantitative and binary traits biorxiv.org/content/10.1101/…
Subset scanning for multi-trait analysis using GWAS summary statistics medrxiv.org/content/10.1101/…
Genome-wide analyses reveal widespread genetic overlap between neurological and psychiatric disorders and a convergence of biological associations related to the brain medrxiv.org/content/10.1101/…
Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum medrxiv.org/content/10.1101/…
Novel genomic loci and pathways influence patterns of structural covariance in the human brain medrxiv.org/content/10.1101/…
PA-FGRS is a novel estimator of pedigree-based genetic liability that complements genotype-based inferences into the genetic architecture of major depressive disorder medrxiv.org/content/10.1101/…
Estimation of indirect genetic effects and heritability under assortative mating biorxiv.org/content/10.1101/…
Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases medrxiv.org/content/10.1101/…
Phenotypic and Genetic Characteristics of Retinal Vascular Parameters and their Association with Diseases medrxiv.org/content/10.1101/…
Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities medrxiv.org/content/10.1101/…
Characterizing personalized effects of family information on disease risk using graph representation learning arxiv.org/abs/2304.05010
Joint models reveal genetic architecture of transitions between pubertal stages and their association with BMI in a Latino population medrxiv.org/content/10.1101/…
Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program medrxiv.org/content/10.1101/…
Polygenic risk score prediction accuracy convergence biorxiv.org/content/10.1101/…
Rapid and accurate multi-phenotype imputation for millions of individuals biorxiv.org/content/10.1101/…
Understanding the genetic complexity of puberty timing across the allele frequency spectrum medrxiv.org/content/10.1101/…
Improved Type 2 Diabetes Risk Stratification in the Qatar Biobank Cohort by Ensemble Learning Classifier Incorporating Multi-Trait, Population-Specific, Polygenic Risk Scores medrxiv.org/content/10.1101/…
