Boxer-4 rally enthusiast, Dairy Plant Engineer survivor, hydrogen pusher, track wrangler, Commissar in His Imperial Majesty's 31st Harakoni Warhawks.
Joined February 2013
- Tweets197K
- Following3.5K
- Followers1.4K
- Likes47K
Pinned Tweet
Current state of NY Penn->LA Union rail in this country is a total of 3,224 miles in 67 hours, assuming no delays and with a half-day layover at Union Station, Chicago. Which pretty much will be eaten up by 48's trip westbound from Albany. Usually.
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
I'm surprised no one in this debate talks about Dassault. Zero fatalities on the 2000, 7X, and 8X. Tri-jet design on many models. No T-tails.
It's also the brand of choice for Taylor Swift who has to owned a Falcon 50, 900, and 7X (current plane).
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
I trained to fly in FL. My instructor pointed at a distant mass of CB & said, "stay at least 50 miles from those sons of bitches."
"OK."
<Reaches around, grabs me by the collar> "I'm fucking serious, man! You stay the FUCK away from them. At least 50 miles!"
"Yeah, yeah, I got it!"
"PROMISE!"
"I promise." <sob>
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
Guy who makes jet engines for a living here, no, jet engines will not survive a high energy impact with the ground. This is incredibly dumb.
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
My “favorite” thing about the modern battle shounen fan is how he’s a complete microcosm of the incurious normie, planted within an interest once immune to them. DBZ and Kenshin fans never acted superior if they found out you liked Chobits. They probably read it too.
This. Fucking this. The fact that we know all of this information was because she was reading shit out until the last.
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
Horatio Nelson went to sea at 12 and was a post-captain at 20, with a warship and every man aboard her answering to him
Now morbidly obese grown "adults" get excited about a cartoon mouse
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
Haitian gang members when their opponent is an actual military instead of unarmed women and children
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
As someone who has - more than once - been fairly sure he was going to die while piloting an aircraft, I think this asshole should go screw himself.
A pilot should not:
🔘become hysterical
🔘speak too quickly to be intelligible
🔘say, "We're going to crash into the ground!"
🔘scream like a little girl
🔘hyperventilate
🔘scream like a little girl again
A pilot needs a certain disposition. This is not it. That's the reality.
Readers added context they thought people might want to know
The aircraft was in an uncontrolled overspeed dive exceeding 20,000 ft/min from cruising altitude. Expecting calm is unrealistic; male pilots have screamed in CVRs facing death, e.g. Western 2605.
fox13news.com/news/were-gonn…
en.wikipedia.org/wiki/Western_A…
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
>be cell biology postdoc at UCLA, 1986
>job: purify vesicles from rat liver
>ez
>purify the vesicles
>something else in the tube
>weird little barrels, way bigger than a ribosome
>fkisdis
>purify the barrels instead
>mostly protein, tiny bit of RNA
>not related to vesicles at all
>new organelle just dropped?
>lab holds a naming contest
>"vaults" "sure, "great name" "
>write it up, publish
>conclusion section: "function: unknown"
>surely we'll figure it out in a couple years
>reviewers: "are you sure this isn't just a virus"
>prove it isn't a virus
>apply for grants to study it
>first question on every call: "what does it do"
>"we're working on it"
>be early 90s
>vaults hang around the nucleus
>"they must plug the nuclear pores"
>they do not
>be different scientist, Netherlands, 1995
>chasing LRP, mystery protein that shows up in chemo-resistant tumors
>clone it
>~88% identical to rat vault protein
>it was vaults the whole time
>whole cancer field piles on
>a decade of papers on vaults and drug resistance
>nobody ever proves vaults cause it
>back at UCLA
>one of the vault proteins binds telomerase
>"guys what if this is the fountain of youth"
>knock it out in mice
>telomeres fine, aging fine, mice fine
>2002
>knock out the main vault protein
>mice: perfectly healthy
>knock out all three vault proteins
>completely vaultless mice
>mice: basically fine, some subtle immune stuff
>mfw something in every cell since the dawn of eukaryotes does nothing obvious
>"just test it in yeast"
>yeast don't have vaults
>"worms then"
>no vaults
>"fruit flies"
>no vaults
>mfw every easy model organism dropped them
>try making recombinant vaults in insect cells
>expecting to get some loose protein at best
>get fully assembled vaults
>can't find a single free copy of the protein anywhere
>turns out ribosomes 3D-print the barrel straight off the mRNA
>lolwut
>still no function
>be structural biologists
>spend years modeling it as 96 proteins with 8-fold symmetry
>2009 X-ray structure
>it's 78 proteins, 39-fold
>caps still blurry
>2025: caps are closed, 13-fold, tiny hole in the middle
>still no function
>NIH funds vault research for 15 years
>NIH: "so what does it do"
>"...we're working on it"
>NIH stops returning calls
>if we can't figure out what it does, we'll make it do something
>stuff a cancer-fighting chemokine inside the barrel
>inject into mouse lung tumors
>immune cells swarm in, tumors shrink
>2011: "human trials within three years"
>2024: "human trials next year"
>2025 database: preclinical
>start a YouTube channel explaining vaults to anyone who'll listen
>be different scientist, Broad Institute
>want to record what genes a cell turned on over time
>try tethering mRNA to a bacterial protein
>doesn't work
>stumble onto a YouTube channel about some obscure barrel organelle
>engineer vaults to grab mRNA
>RNA half-life goes from ~17 hours to ~132 hours
>publish in Science, 2026
>use it to catch drug-resistance genes in lung cancer cells before the drug even hits
>the vault guy is thrilled
>still nobody knows what vaults are for
>be epigeneticists
>screen the whole genome for methylation set at random in the early embryo
>separately study kids conceived in different seasons in rural Gambia
>both screens independently point at the same gene
>it's the goddam vault RNA gene
>its methylation depends on conditions around conception, locked in for life
>linked to cancer outcomes, blood sugar, cleft palate
>mfw the mystery barrel has a mystery RNA that remembers when you were conceived
>40 years later
>one of the most abundant structures in your cells
>still not in a single textbook cell diagram
>we use it anyway because yolo
>function: unknown
>be CNRS scientist in montpellier
>dig through institut curie's chemical library looking for an HIV cure
>find a quinoline that blocks rev from exporting viral RNA
>somehow involved in splicing
>start a company called splicos based on this
>4 years later, company gets merged into abivax
>molecule is now ABX464
>run two phase 2a HIV trials
>it shrinks the viral reservoir a bit
>mfw "a bit" does not cure HIV
>but the bloodwork is weird
>random microRNA miR-124 is cranked tf up
>mfw miR-124 is a major chill pill for inflammation
>turns out the drug grabs the cap-binding complex and splices exactly one random lncRNA
>that lncRNA becomes miR-124
>why that one? lol idk
>HIV attacks GI tract, so maybe give it to colitic mice?
>guts heal lmao
>let's yolo this for ulcerative colitis
>2018 phase 2a works
>let's try with rheumatoid arthritis while we're at this
>2020 covid hits
>"what if it stops cytokine storms"
>yeah let's cure ARDS too lol
>french gov makes it a national research priority
>500 patients in
>2021 trial stopped, does nothing
>stock eats dirt
>ceo: "covid was hyper-acute, chronic inflammation is different, trust me"
>quietly drop rheumatoid arthritis
>go all in on UC
>phase 2b works
>2025 phase 3 induction hits
>stock goes vertical
>2026 maintenance trial: half get remission on drug vs 10 % on placebo
>placebo rate is the lowest ever seen in a trial like this
>NDA to FDA planned late 2026
>mfw a failed HIV drug, a failed covid drug, and a lucky lncRNA might become a blockbuster UC pill
>mfw it took 18 years
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
I was winged a United States Naval Aviator when I was 23.
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
<Help make a universally popular show about the life of Jesus
<Keep it as ecumenical and non-identifiably Mormon as possible
<Six seasons in, switch it to the Book of Mormon so that world-wide Christian audience will be exposed to it
The LDS church plays the long con well
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
When a high speed shaft on an SH-60B explodes into about a million razor sharp shrapnel pieces that shred the engine compartment and turn the airframe into Swiss cheese, I challenge you not to talk kinda fast for a few seconds.
Dickhead.
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
Captain Charles McVay of the U.S. Navy sat on his Connecticut porch in 1968 and ended his life over a crime he never committed.
In July 1945, after his heavy cruiser USS Indianapolis delivered parts of the atomic bomb to Tinian, a Japanese submarine sank the ship at night. Nearly nine hundred American sailors went into shark-infested waters, and only 316 survived.
The U.S. Navy Lost over 350 ships in World War II, yet McVay was the only captain ever court-martialed for losing his ship in combat.
Why did the Navy prosecute him? Brass in Washington had denied McVay a destroyer escort and hid top-secret ULTRA intercepts proving Japanese submarines were hunting on his route, so they scapegoated him for "failing to zigzag" in pitch darkness.
For fifty years, Pentagon rules blocked every attempt by his surviving crew to clear his name.
Then in 1996, a twelve-year-old boy in Pensacola, Florida named Hunter Scott started a school history project. He interviewed nearly 150 aging survivors, gathered 800 documents, and took the fight to the U.S. Senate.
And one more man stepped forward from across the Pacific to stand beside that twelve-year-old American boy.
It was ninety-year-old Mochitsura Hashimoto, the very Japanese submarine commander of I-58 who had sunk the Indianapolis, now serving as a Shinto priest in Kyoto.
"Our peoples have forgiven each other for that terrible war," Commander Hashimoto wrote to the U.S. Senate Armed Services Committee in 1999, testifying that no zigzag could have saved the ship. "Perhaps it is time your peoples forgave Captain McVay for the humiliation of his unjust conviction."
On October 30, 2000, the U.S. Congress and the President officially exonerated Captain McVay.
Bureaucracies protect their own mistakes. Warriors and children protect the truth.
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
She was a 65 yr old ship. 90% of the tech to run her reactors doesn't exist anymore. We had to send crews in 2003 to Philly and Bremerton just to strip older Kitty Hawk and Forrestal carriers just to get some of the electrical components for repairs due to age.
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
The whole thing about drinks at the Afterlife being named after legends of Night City, and Adam Smasher existing are all part of one of the really great rules of the Cyberpunk TTRPG: No good endings in Night City.
The rulebook explicitly states that Adam Smasher isn’t a balanced character, even a fully stocked and prepared end-game crew will just be wiped out by him because he’s essentially a force of nature. He exists to reinforce the fact that there’s always a bigger fish, and there’s no such thing as actually defeating the corps. If you hit Arasaka’s bottom line too hard, you get Smashed.
Adam Smasher is a campaign-ender, he exists to crush the party at the end of their finale heist, and then the next campaign everyone makes their drinks at the Afterlife named after their last character.
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
I do pride myself of zero of my students getting into a class A
I hope my students' students did the same.
That's better than a .330 batting average on the Yankees
Or 5 ypc for a running back
I did my job well on that score
Commissar Geo Bartlette (31st Harakoni Warhawks) retweeted
Air Force student pilots receive a manual called “The Road To Wings”.
It documents training mishaps since 1972. Students learn from the misfortune of others. I’ll link it below.
The closing is “The Troop Who Rode One In” (didn’t eject & died in the crash). If I may…
“We should all bear one thing in mind when we talk about a troop who rode one in. He called upon the sum of his knowledge and made a judgment. He believed in it so strongly that he knowingly bet his life on it. The fact that he was mistaken in his judgment is a
tragedy, not stupidity. Every supervisor and contemporary who ever spoke to him had an opportunity to influence his judgment. So a little bit of all of us goes in with every troop we lose.”
-Anonymous
I tried to remember that as an instructor. It’s part of what I’m trying to do on here now.
Anyway, as promised, here is the link:
static.e-publishing.af.mil/p…
