@GharpureLab

This group focuses on synthesis of natural and unnatural product and developing new synthetic methodologies. Student-run twitter account for Gharpure Lab IITB..

 IIT Bombay
ether.chem.iitb.ac.in/~sjgharpure/
Joined July 2020
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  • Following266
  • Followers417
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Gharpure Lab retweeted
Chandra Volla@ChandraVollaSep 18
Department of Chemistry, IIT Bombay @Chemistry_IITB @iitbombay will be hosting the XXI J-NOST conference from 6th-9th Dec 2026 at VMCC auditorium chem.iitb.ac.in/jnost2026/in… Deadline to submit the abstract: 25th September 2026. @jnost2026 @GharpureLab @Jatin_Patra5 @ignitedmind02
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A symposium on Innovations in Natural Products and Synthetic Strategies (INPSS) was held at The Park Hotel, Hyderabad. The event was organised in honour of Prof. A. Srikrishna's 70th Birthday. Eminent speakers from across India delivered insightful talks on cutting-edge research.
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In #OrgLett: @GharpureLab from @iitbombay shares a unified strategy for the synthesis of spiroketals from cyclopropenes! @sjgharpure, @guptakrish50 go.acs.org/c6W

Harnessing the Reactivity of Cyclopropenes in the Synthesis of Spiroketals via Putative Generation...

Abstract. TMSOTf-mediated 5/6-exo-trig hydroalkoxylation followed by the (3 + 2) cycloaddition cascade reaction of hydroxy cyclopropenes with aldehydes gav

pubs.acs.org
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In #OrgLett: @GharpureLab reports MHAT segment coupling of alkenols with acceptors via C-C radical translocation and remote oxidative 1,5/6-hydrogen atom transfer @sjgharpure, @RupaliSChavan, @DipakFartade go.acs.org/bCP

Iron-Mediated Segment Coupling of Alkenols with Acceptors via C–C Radical Translocation and Remote...

Abstract. Iron-mediated segment coupling followed by oxidative 1,5/6-hydrogen atom transfer (HAT) for synthesis of ε-oxo alkene derivatives is developed. T

pubs.acs.org
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In #OrgLett, @GharpureLab from @iitbombay demonstrates PIDA mediated keto-oximation of O-alkynyl hydroxylamines for the synthesis of 3-acyl isoxazolines and 1,2-oxazines. @sjgharpure, @kaushikpatel94, @JuhiPal16, @showkat_09, @sanyog_negi go.acs.org/bzr
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In #OrgLett: @GharpureLab from @iitbombay demonstrates a simple tweak in gold(I) catalyst loading and reaction time results in divergent formation of isoxazolidine & isoxazoline via hydroamination/1,3-sulfonyl migration cascade. @sjgharpure, @JuhiPal16 go.acs.org/ai2

Harnessing Gold(I)-Catalyzed Hydroamination/1,3-Sulfonyl Migration Cascade for Divergent Synthesis...

Abstract. Gold-catalyzed 5-exo-dig hydroamination on O-homopropargylic hydroxylamine gave expeditious access to methylene isoxazolidine. Excess catalyst lo

pubs.acs.org
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Now in #OrgLett @GharpureLab reports MHAT 5-exo-trig and Baldwin-disfavoured 5-endo-trig radical cyclization for the synthesis of fused indoles and pyrroles, and accomplished total synthesis of bruceolline E/H pubs.acs.org/doi/10.1021/acs… @sjgharpure @RupaliSChavan @simrannarang89
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Gharpure Lab retweeted
EurJOC@EurJOC4 Oct 2023
Enantiospecific Total Synthesis of (-)-Hyacinthacine A1 and (+)-Hyacinthacine A1 and Their Homologues Using Nitrogen Substituted Donor-Acceptor Cyclopropane by @sjgharpure and @Rajpatel_91 @GharpureLab onlinelibrary.wiley.com/doi/…

Enantiospecific Total Synthesis of (−)‐Hyacinthacine A1 and (+)‐Hyacinthacine A1 and Their Homolo...

Utilizing the nitrogen-substituted donor-acceptor cyclopropane, enantiospecific total syntheses of (−)-hyacinthacine A1⋅HCl and (+)-hyacinthacine A1⋅HCl were achieved. The key reactions were highly...

chemistry-europe.onlinelibrary.wiley.com
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Happy to share our new approach for the enantiospecific total synthesis of both the isomer of Hyacinthacine A1 and their homologous !
EurJOC@EurJOC4 Oct 2023
Enantiospecific Total Synthesis of (-)-Hyacinthacine A1 and (+)-Hyacinthacine A1 and Their Homologues Using Nitrogen Substituted Donor-Acceptor Cyclopropane by @sjgharpure and @Rajpatel_91 @GharpureLab onlinelibrary.wiley.com/doi/…

Enantiospecific Total Synthesis of (−)‐Hyacinthacine A1 and (+)‐Hyacinthacine A1 and Their Homolo...

Utilizing the nitrogen-substituted donor-acceptor cyclopropane, enantiospecific total syntheses of (−)-hyacinthacine A1⋅HCl and (+)-hyacinthacine A1⋅HCl were achieved. The key reactions were highly...

chemistry-europe.onlinelibrary.wiley.com
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Stereoselective Synthesis of Pyrrolo/Pyrido[2,1-a]isoindoles via Alkyne Iminium Ion #Cyclization of Vinylogous Carbamates. Santosh Gharpure et al. @iitbombay @GharpureLab @sjgharpure @sanyog_negi onlinelibrary.wiley.com/doi/…

Stereoselective Synthesis of Pyrrolo/Pyrido[2,1‐a]isoindoles via Alkyne Iminium Ion Cyclization of...

A diastereoselective synthesis of pyrrolo/pyridoisoindole via alkyne iminium ion cyclization of vinylogous carbamate is described. This protocol features a broad substrate scope and easy scalabilit...

aces.onlinelibrary.wiley.com
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New in #OrgLett @GharpureLab demonstrates base-promoted synthesis of cyclic and spiro heterocyclic β-ketosulfones via hydroalkoxylation-initiated cascade of sulfone-tethered aryl alkynols pubs.acs.org/doi/10.1021/acs… @sjgharpure, @DipakFartade, @Santoshknanda87, @Shipra_1997
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Replying to @DharmendraSVish @JOC_OL @sjgharpure @Rajpatel_91 @guptakrish50
Thank you..
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Replying to @nanda_laxmi
Thank you..
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Happy to share our new approach for pyrrolidine and piperidine natural products synthesis.
J Org Chem/Org Lett@JOC_OL1 Aug 2023
Now showing in #OrgLett, @GharpureLab discloses the stereoselective total synthesis of pyrrolidine and piperidine alkaloids via TMSOTf mediated ‘5/6-endo-dig’ reductive hydroamination of enynyl amines. See it here pubs.acs.org/doi/10.1021/acs… @sjgharpure, @Rajpatel_91, @guptakrish50,
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