@GilPerotin

Neuroimmunologist, ICU, person-centered, avid book reader, women’s rights defender, mother. This is my opinion.

Joined February 2022
  • Tweets928
  • Following569
  • Followers349
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Oct 19
Fascinating work showing immunologic changes years prior to clinical onset of NMOSD. Congrats to all the investigators! Innate Immune Dysregulation Precedes Clinical Onset in Neuromyelitis Optica biorxiv.org/content/10.64898…

Innate Immune Dysregulation Precedes Clinical Onset in Neuromyelitis Optica

Neuromyelitis optica spectrum disorder (NMOSD) is a disabling inflammatory central nervous system (CNS) disease characterized by pathogenic aquaporin 4 (AQP4) autoantibodies. The biological events...

biorxiv.org
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Joe Sabatino@jsabatino37Oct 18
Antiviral and inflammatory immune signatures in anti-CD20-treated multiple sclerosis: a cross-sectional study link.springer.com/article/10…

Antiviral and inflammatory immune signatures in anti-CD20-treated multiple sclerosis: a cross-sec...

Journal of Neurology - CD20-targeting monoclonal antibodies are highly effective therapies for relapsing multiple sclerosis (MS). We examined how anti-CD20 therapy reshapes antiviral T-cell...

link.springer.com
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Oct 7
Comparative Effectiveness of Treatments for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Congrats @tweetsatakash and colleagues! neurology.org/doi/10.1212/WN…

Comparative Effectiveness of Treatments for Relapse Prevention in Myelin Oligodendrocyte Glycopro...

Background and ObjectivesThe most effective treatment strategy to prevent relapses after a first myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) event remains unclear. Our...

neurology.org
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Sep 19
Anti-CD40L prevents meningeal B cell aggregates and mitigates progressive autoimmune encephalomyelitis academic.oup.com/brain/advan…

Anti-CD40L prevents meningeal B cell aggregates and mitigates progressive autoimmune encephalomye...

Immune cell aggregates in the meninges are believed to drive chronic pathology in multiple sclerosis. Tyystjärvi et al. show in an animal model that an ant

academic.oup.com
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Sara G. Gil-Perotin retweeted
Angel Pérez Sempere@AngelPSempereSep 1
CAR T-cell deaths in subjects with autoimmunity, by @GavinGiovannoni gavingiovannoni.substack.com…
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Joserra 🍉@jramonfernandezAug 12
Llevo 20 años como neonatólogo y he hecho unos cuantos traslados de neonatos a otras comunidades, pero lo que estamos viviendo con un traslado de un neonato a Barcelona es lo más surrealista y menos profesional que he visto en mi vida. Va hilo @semgencat @salvadorilla @salutcat
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Aug 10
Adoptive T-cell therapies in neuroinfectious and neuroinflammatory diseases academic.oup.com/brain/advan…

Adoptive T-cell therapies in neuroinfectious and neuroinflammatory diseases

Several adoptive T cell therapy platforms are emerging as promising treatment strategies for refractory neuroinfectious and neuroinflammatory diseases. Lam

academic.oup.com
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Aug 9
Age-Associated B Cells: Origins, Regulation, and Tissue-Specific Pathogenic Contributions in Autoimmune, Metabolic, and Neurological Diseases onlinelibrary.wiley.com/doi/…

Age‐Associated B Cells: Origins, Regulation, and Tissue‐Specific Pathogenic Contributions in...

Age-associated B cells (ABCs) are a distinct B cell population characterized by coexpression of T-bet and CD11c. First described in aged female mice and autoimmune-prone strains, ABCs are now...

onlinelibrary.wiley.com
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Aug 2
A Threshold in Anti–EBNA-1 Antibody Titers Distinguishes Salivary EBV Shedders From Nonshedders academic.oup.com/jid/article…

A Threshold in Anti–EBNA-1 Antibody Titers Distinguishes Salivary EBV Shedders From Nonshedders

Low outlier anti–Epstein–Barr virus nuclear antigen (EBNA)-1 titers define a nonshedder phenotype with no detectable salivary Epstein–Barr virus (EBV) desp

academic.oup.com
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Sara G. Gil-Perotin retweeted
NEJM
@NEJMJul 7
Multiple sclerosis is a chronic autoimmune disorder that affects the central nervous system, causing episodes of neurologic dysfunction and often gradual disease progression. Important advances in treatment have improved outcomes in patients with relapsing forms of multiple sclerosis. However, treatment options for progressive forms remain limited, which highlights the need for therapies that can prevent progression and promote myelin repair. Learn more: nej.md/3SDJGcn
A bullet list of key points from the Review Article "Advances in Multiple Sclerosis" on a yellow background. The New England Journal of Medicine is featured at the bottom.

ALT A bullet list of key points from the Review Article "Advances in Multiple Sclerosis" on a yellow background. The New England Journal of Medicine is featured at the bottom.

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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Jun 23
Epstein–Barr virus and multiple sclerosis: from associations to mechanisms to potential therapies sciencedirect.com/science/ar…
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Jun 17
Deciphering small sequence differences in T cell receptor-antigen pairing nature.com/articles/s41467-0…

Deciphering small sequence differences in T cell receptor-antigen pairing

Nature Communications - Computational prediction of peptide-MHC (pMHC) antigen binding to T cell receptors (TCR) is useful for T cell-based therapeutic development and predicting responses to...

nature.com
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Jun 7
Refined single-cell profiling captures a CCR5high CD4+ cytotoxic T-cell precursor in multiple sclerosis thelancet.com/journals/ebiom…

Refined single-cell profiling captures a CCR5high CD4+ cytotoxic T-cell precursor in multiple...

We show that low-frequency, circulating Th17.1 cells harbour a unique MS-associated CCR5high cluster with enhanced cytotoxic and CNS-infiltrating potential. This CD4+ cytotoxic T-cell precursor could...

thelancet.com
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Sara G. Gil-Perotin retweeted
GVA Sanitat@GVAsanitatMay 18
🏥 @HospitalLaFe encabeza el ranking español de trasplantes de médula ósea ➡️ El centro realizó 172 trasplantes de progenitores hematopoyéticos el año pasado, de los cuales 155 correspondieron a pacientes adultos y 17 a población pediátrica 🔗 breu.gva.es/b/jC-GW4Ys
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Sara G. Gil-Perotin retweeted
#metoo hospitales
@PtoazulsanidadMay 10
Por cierto, esta frase es la más importante del trabajo.
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Sara G. Gil-Perotin retweeted
Neurology Journal@GreenJournalMay 9
The findings in this study provide the first evidence of higher-than-expected skin phosphorylated alpha synuclein deposits in a large cohort of patients with essential tremor. Learn more: hubs.la/Q04f_t_80
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Sara G. Gil-Perotin retweeted
Redescubre La EM
@RedescubreLaEMMay 8
La actriz Christina Applegate fue diagnosticada en 2021 con #EsclerosisMúltiple. Ahora, acaba de publicar You with the sad eyes (Tú con los ojos tristes), un libro de memorias en el que describe su lucha contra la enfermedad. Unas memorias que la propia actriz ha dicho haber escrito “desde la voluntad de ser honesta y de ofrecer esperanza”. lavanguardia.com/gente/20260…
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Sara G. Gil-Perotin retweeted
Vivian Capilla-González@VivianCG_LabMay 6
🧠On May 18, the Burjassot Campus (@UV_EG) will host the Workshop "Understanding Adult Neurogenesis through NSCs and their Niches", in tribute to José Manuel García Verdugo. Don´t miss it. Free registration here👇 l1nk.dev/thrx75b @UCSF @cabimer @MayoClinic
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Apr 28
Cause, consequence, or synergy: the role of T-cell infiltration across neurodegenerative diseases academic.oup.com/brain/advan…

Cause, consequence, or synergy: the role of T-cell infiltration across neurodegenerative diseases

We read with great interest the recent study by Couto et al.,1 which reported increased cytotoxic T cells in post-mortem substantia nigra (SN) tissue from

academic.oup.com
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Sara G. Gil-Perotin retweeted
Joe Sabatino@jsabatino37Apr 24
Multiple sclerosis-associated HLA demarcates EBV-specific CD8+ T cells with an exhausted and brain residency phenotype sciencedirect.com/science/ar…
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