Haematopoiesis and Immunity Lab, Translational and Clinical Research Institute
Newcastle University
Joined November 2014
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It has been great working with @ImogenFranklin6, @sarahjpickett, Oliver Russell, @MitoResearch on this project showing that T cell differentiation drives the negative selection of pathogen mtDNA variants in mitochondrial disease! life-science-alliance.org/co…
We are very happy to have been involved in this worldwide, genome-wide study of Erdheim Chester Disease. Demonstrating that germline genetic variants can impact on the development of ECD and suggesting new pathways with a potential pathogenic role. acrjournals.onlinelibrary.wi…
And Callum with host versus graft DP-mismatching: those resident T cells may be at the root of GVHD tissue tropism . . . rdcu.be/dcach
Paul's latest paper on lineage-switch in Langerhans cell histiocytosis: authors.elsevier.com/sd/arti…
Congratulations to Dr Callum Wright on the publication of this paper! 🎉🎉
"Host versus graft HLA-DP1 mismatching promotes graft versus host disease"
rdcu.be/dbv7a
The origins of LCH revealed: news.ki.se/researchers-have-…
Many thanks to @EgleKvedaraite for getting us involved in this great study!
Myeloid lineages talk to each other and it’s anything but small talk
We found their Notch dependent cross-talk promote Langerhans Cell Histiocytosis pathology
Now out in @SciImmunology @FGinhoux 🧵scim.ag/Tk
Congrats Egle, Florent and Paul @HI_Lab_NCL and all the team for a key insight into histiocytosis and DC at Science Immunology science.org/doi/10.1126/scii…
Notch-dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology science.org/doi/10.1126/scii…
60% of Langerhans Cell Histiocytosis patients have the BRAFV600E mutation; found in myeloid cells. We show that the remaining patients also carry mutations in myeloid cells, suggesting that treatment strategies may be similar regardless of mutation. ashpublications.org/bloodadv…
Histiocytosis patients can be treated with targeted inhibitors but long-term side effects are unknown and relapses can occur after treatment withdrawal. We show mutated cells switch over time, potentially indicating when it is safe to withdraw treatment. ashpublications.org/bloodadv…
Great new paper in collaboration with @sbomken discussing the epigenetic regulation of lineage switching leukaemia and getting the cover image! ashpublications.org/blood/ar…
Haematopoiesis and Immunity Lab retweeted
#BSI22
Lovely plenary session by @vhbigley, a beautiful story of IRF8 -dependent DC haematopoiesis in the innate inborn immunodeficiencies
Take a look at our newly published review #immunodeficiency #dendriticcells authors.elsevier.com/a/1azW8…
Beautiful morning for our away day in Cullercoates @NCLDoveMarine
Haematopoiesis and Immunity Lab retweeted
Our new blood test in #Newcastle could offer a quicker, cheaper, painless way to detect #Leukemia #bloodcancer #aml. Currently we’re in the top 5% of altmetrics while under review! Please RT. biorxiv.org/content/early/20…
See a preview of our latest paper defining human dendritic cell development - Differential IRF8 Requirement Defines Two Pathways of Dendritic Cell Development in Humans papers.ssrn.com/sol3/papers.…
Haematopoiesis and Immunity Lab retweeted
Read our paper here describing a simple blood test to follow treatment response #bloodcancer #leukemia Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia biorxiv.org/content/10.1101/… thank you @CRUK @BrightRedOrg for funding
Read our latest paper on a simple prognostic blood test for monitoring AML - Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia biorxiv.org/content/10.1101/…