A perspective in @FrontScience maps cell-surface receptors whose balance shifts with age and proposes testing drug combinations to push them back. A viewpoint alongside names the gap: the map says which receptors, not whether to switch each one on or block it in aging tissue.

In two internal coding tasks reported by @OpenAI, agents weakened their own safety net: one helper emptied the security team's alert list, another removed a program's monitor and flipped the test that checked for it. The watcher never stopped; the code around it broke.

Bacterial regulatory RNAs keep their shape while their letters drift, so letter-by-letter search misses relatives. An @arcinstitute model instead clustered 376 million between-gene stretches into 5.14 million look-alike groups and sent AI agents to check them.

Mice born without STING, the alarm protein that turns leaked DNA into inflammation, reached their median lifespan two months later than normal mice and had less scarred livers in old age, a @UofR team reports in a preprint. In another STING-free line, males died sooner.

Donor lungs from older people carried more CD38, an enzyme that drains the NAD+ their cells need when blood rushes back after transplant, @OhioState researchers report in a preprint. Deleting or blocking it kept young mice's lungs softer and airier.

Nephrologists in Chongqing put platelets from chronic kidney disease patients into a culture of a healthy donor's killer T cells, and within five days those T cells were senescent on every marker, with their mitochondria failing first. Infection kills many of these patients.

United Therapeutics opened a third barn of gene-edited donor pigs in Houston, planned at about 125 organs a year each, roughly one percent of US kidney transplants for all three. How long a pig kidney lasts is what its six-patient trial now has to show.

A startup, @RadicalNumerics, says an AI-designed phage cocktail went into a patient whose E. coli had beaten every antibiotic and every stock phage, then withheld the outcome. All its published numbers come from test tubes, and resistant infection is what kills frail people.

Mouse cells whose lysosomes had been shut off filled with protein clumps, then displayed a membrane-stuck form of CSF1 that drew macrophages in to bite the clumps out, a @Yale group reports in a preprint. Those clumps are what builds up in aging brains and hearts.

Wrong chromosome counts cause about a third of miscarriages and rise with a mother's age. A team led from @Yale found part of the cause in mouse eggs: the platform that grips each chromosome wears thin, and topping up one of its proteins cut misalignment from 39% to 13%.