See how a AAA+ machine uses stochasticity to promote fast protein translocation:
youtu.be/J5An-TBEjZk
Want to learn how single-molecule FRET can study the translocation of proteins by AAA+ machines (youtu.be/J5An-TBEjZk)?
Read this paper: biorxiv.org/content/10.1101/…
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Our newest paper uses single-molecule FRET to reveal how the AAA+ machine ClpB uses a Brownian-ratchet like mechanism to translocate proteins - taking milliseconds, depending weakly on temperature, and sometimes starting in the 'wrong' direction.
doi.org/10.1101/2025.03.13.6…
New paper alert!
How do enzyme motions contribute to catalysis? Using single-molecule FRET, we uncovered how a denaturant enhances adenylate kinase activity—through controlling conformational dynamics and fine-tuning substrate binding!
Read more here: doi.org/10.1039/D4SC06819J
