@HarbauerL

Lab founded in 2019 - #Neurometabolism - in love with #mitochondria https://xitter.cf/t.co/iQmrlLIIct

Joined August 2019
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  • Followers572
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Excited to share this recent preprint from the @MickLab. They cleverly join APEX-proximity biotinylation, which usually requires exogenous addition of H2O2, with D-aminacid-induced local H2O2 production by expression of the yeast DAO. It's genious! biorxiv.org/content/10.1101/…

iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic...

Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background...

biorxiv.org
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HarbauerLab retweeted
IMPRS-TP@ImprsTp15 Aug 2024
🚨Opportunity Alert! 🧠Apply now for our fully funded #PhD Positions in #Neuroscience & #Translational #Psychiatry 📝at applications.imprs-tp.mpg.de ⌛️until 31. Oct ℹ️imprs-tp.mpg.de/3041/instruc… ❓ imprs-tp.mpg.de/97967/FAQs 🔃 Please share/retweet #PhDposition #hiring #Job #research
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Updated version of this manuscript is up now! We have new @zeiss_micro lattice-SIM data from our brilliant postdoc @JulienCicero showing how mito-associated actin bridges fusing mitochondria. We also have new data showing that mito-actin precedes MFN2 location to fusion sites 🤩
Uri Manor
@manorlaboratory21 Jun 2023
Alright I'm home sick with COVID and just submitted my grant, so I finally have bandwidth to do this now. So either buckle up or mute this thread (or both?!) cuz we're going on a journey combining brand new tools and new fundamental biological discoveries made with those tools.
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We are thrilled to announce the first #Munich Postdoc Night on Sept. 12th @badw_muenchen! Talk about your research with peers from different institutions and disciplines in Munich! Register until July 21st to present a poster at the event! munich-postdoc-network.mpg.d…
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Ribosome-Associated Vesicles promote activity-dependent local translation biorxiv.org/content/10.1101/…

Ribosome-Associated Vesicles promote activity-dependent local translation

Local protein synthesis in axons and dendrites underpins synaptic plasticity. However, the composition of the protein synthesis machinery in distal neuronal processes and the mechanisms for its...

biorxiv.org
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Pink surfin’ on the ER – The ER plays an active role in the biogenesis of the #Parkinson protein PINK1 in stabilizing its precursor on its way to #mitochondria in neurons. #mitophagy New preprint from my lab! biorxiv.org/content/10.1101/…

ER-associated biogenesis of PINK1 preprotein for neuronal mitophagy

A central role in mitochondrial quality control is played by the Parkinson-related mitochondrial kinase PINK1, whose mRNA is transported in neurons by mitochondrial hitch- hiking. Using a live-cell...

biorxiv.org
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Please register to get an update on cellular imaging by light and electron microscopy. And of course, to meet friends and make new friends 🤩 #microscopy #cellbiology
GBM e.V.@GBM_eV3 Jun 2024
The GBM Compact conference „Focus on Imaging“ takes place from September 26-27 in Frankfurt! Early registration+abstract submisison is possible until June 30. Please visit the conference website for registration and further information: gbm-compact.org
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Molecularly, the Pink1 mRNA tethering complex is phosphorylated by #AMPK to keep the amount of PINK1-mediated mitophagy low. Only upon untethering, e.g. upon inactivation of AMPK by insulin signaling, can mitophagy process and the neuron take care of damaged mitochondria.
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This goes awry in neurons that have lost their ability to respond to insulin, e.g. upon treatment with the #Alzheimers disease (AD) risk factor ApoE4. This connects two phenomena commonly seen in AD, damaged mitochondria and #insulin resistance.
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Use for free access to the paper rdcu.be/dBJUC or visit doi.org/10.1038/s42255-024-0…
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Tabitha identified a molecular switch that allows neurons to turn #mitophagy on and off, by tethering the Pink1 mRNA to mitochondria. This protects #mitochondria in neurons from being used as a simple nutrient source, because we all know they are much more important than that!
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Could not be more proud to share the story one of my first PhD students in the lab. Shout out to Tabitha! For more info and links see below.
MPI for Biological Intelligence@MPIforBI19 Mar 2024
In a new study, @HarbauerL found that insulin supports the recycling of dysfunctional mitochondria in neurons. Energy scarcity or interrupted insulin signals can lead to the continued use of defective mitochondria, which might affect neurodegenerative diseases. Read more: bi.mpg.de/news/2024-03-harba…
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In a new study, @HarbauerL found that insulin supports the recycling of dysfunctional mitochondria in neurons. Energy scarcity or interrupted insulin signals can lead to the continued use of defective mitochondria, which might affect neurodegenerative diseases. Read more: bi.mpg.de/news/2024-03-harba…
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Amidst our focus on sustainability, digitalization, cybersecurity, and AI, it's crucial to ensure that research, skills, ideas, and the workforce are equally accessible. Remember, girls represent half of tomorrow's world — let's not leave them behind! #WomenAndGirlsInScienceDay
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Cool story on how local translation shapes mitochondria: FMRP granules drive mitochondrial fission via local translation in neurons: Biophysical Journal cell.com/biophysj/fulltext/S…
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The long anticipated preprint is here! Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP biorxiv.org/content/10.1101/…

Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP

In neurons of the mammalian central nervous system (CNS), axonal mitochondria are thought to be indispensable for supplying ATP during energy-consuming processes such as neurotransmitter release....

biorxiv.org
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Replying to @HarbauerL
@HarbauerL we're looking forward to your presentation at #MCS24 in Mexico this February! 🇲🇽☀️ Please RT to let your followers know you'll be speaking, and that Early Bird & Talk Submission deadlines close this Thursday (30 Nov 2023). Find out more➡️bit.ly/3N5rq66
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HarbauerLab retweeted
mito911@mito911_15 Jan 2024
🚨In 1 week! Join us at the @mito911_ series for @HarbauerL talk on #mitochondrial #health maintenance in #neurons!
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So, luck nature.com/articles/s41467-0…

Early coauthorship with top scientists predicts success in academic careers

Nature Communications - By examining publication records of scientists from four disciplines, the authors show that coauthoring a paper with a top-cited scientist early in one's career predicts...

nature.com
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