HarbinBook

Lifespan drugs are mostly saving fat mice from early death. This is well known in the field: compounds that extend lifespan seem to have a much smaller effect, if any, on individuals in optimal health. Linda Partridge and Bouvet now show this by pooling 33,780 mice from the NIA's Interventions Testing Program. In males the median lifespan gain was 6.2% in the lightest quarter and 20.2% in the heaviest. Most of the effect comes from heavy untreated mice dying sooner. The effect is weak in females. biorxiv.org/content/10.64898…

Bigger Than Louvre And British Museum: What Yuge Yugeen Bharat Project Means news18.com/india/bigger-than… via NaMo App

AlphaGenome 2 is helping uncover the cellular drivers of disease, giving scientists a powerful tool to predict how DNA variants impact specific cell types. Every cell in our body shares the same DNA blueprint, but different cell types (like heart muscle cells vs. immune cells) read that blueprint differently. This new @GoogleDeepMind model predicts how these specialized cells interpret DNA, turning genetic code into biological insights. Building on AlphaGenome 1 this makes it significantly easier for researchers to link genetic findings to the root causes of disease in the specific cells where they actually unfold.

@RadicalNumerics’ apology (radicalnumerics.ai/blog/phag…) is a positive step. Rebuilding trust that this won't recur requires accountability & changes in how they handle collaborations & communications. The apology did not acknowledge their use of patient care for publicity without the care team’s consent, which remains a serious concern, demanding publicly-stated & believable preventative measures.  The apology said "Tabula played a leading role ... including in AI" but followed with "Radical is an AI research lab, and our contribution was AI-generated phages."  Whether this was actually a positive contribution relative to other models requires data (lack of which is yet another reason why their PR to @NYTimes 20-Oct was a poor choice endpoints.news/church-quits-…). The experimental results I have reviewed show promising performance from @TabulaBio’s models, & I regard Tabula as a leader in AI-driven phage design.

I wanted to share some context around the recent discussion of our phage work. A few thoughts on the collaboration and the path forward. Blog: radicalnumerics.ai/blog/phag…

M 11/9/26 Recording @WorldUnivAndSch #WUaSNewsAndQA @WUaSPress #WUaSWBM youtu.be/ceIbcaTHbo8 -worlduniversityandschool.blo… -scott-macleod.blogspot.com/2… w 10/26 #WUaSAgenda -worlduniversityandschool.blo…  -scott-macleod.blogspot.com/2… -youtube.com/@ScottMacLeodWor… #FantasticSundar #WUaSgenetics ~

Not many are aware that Arthashastra was discovered in my hometown of Mysuru by my great great grandfather R.Shamasastry. en.wikipedia.org/wiki/R._Sha… The manuscript can be seen in the Oriental Research Institute, where he was the director, along with many other priceless palm leaf manuscripts.