Respiratory Clinical Research Fellow, Southmead Hospital and UoBristol. Airways disease and Epidemiology.
Joined June 2017
- Tweets41
- Following135
- Followers82
- Likes371
Daniel Higbee retweeted
Is spirometry, peak flow and FeNo aerosol generating?🫁
Latest data from @NIHRcommunity funded AERATOR study suggests No!
Important implications for diagnostics and monitoring in lung disease
@BristolARU @NorthBristolNHS
@BristolUni
#Asthma #COPD
thorax.bmj.com/content/early…
Daniel Higbee retweeted
The Respiratory Physiology Team are pleased to have been able to support the AERATOR study in demonstrating that spirometry and FeNO generate less aerosols than coughing. 🫁 thorax.bmj.com/content/early…
Daniel Higbee retweeted
Preserved ratio impaired spirometry (PRISm): is it a useful measure of risk of developing chronic obstructive pulmonary disease (COPD)? By @HigbeeDaniel @theotherdodd et al sciencedirect.com/science/ar…
Daniel Higbee retweeted
Understanding the epidemiology and long term implications of Preserved ratio impaired spirometry (PRISm) #COPD #multimorbidity Great working with @HigbeeDaniel Raquel Granell and @mendel_random @mrc_ieu @BristolARU
NEW Research—PRISm in the gen pop was 11% and was strongly associated w/ breathlessness and CV disease. PRISm = a distinct lung function trait, not simply a result of 📈 BMI, underlying asthma, or smoking.
Read the cohort analysis from James Dodd & co bit.ly/3GIrtQx
Daniel Higbee retweeted
NEW Research—PRISm in the gen pop was 11% and was strongly associated w/ breathlessness and CV disease. PRISm = a distinct lung function trait, not simply a result of 📈 BMI, underlying asthma, or smoking.
Read the cohort analysis from James Dodd & co bit.ly/3GIrtQx
Daniel Higbee retweeted
This two-sample multivariable Mendelian randomisation study provides strong evidence that FVC (but not FEV1 or FEV1/FVC <0.7) is causally associated with coronary artery disease bit.ly/3t05kWJ
Daniel Higbee retweeted
If you are a medical, dentistry or vet student who is considering intercalating next year, why not consider our iBSc in genomic medicine at the University of Bristol and get ahead of the genomics revolution in medicine. Please RT.
Calling Medical, Dentistry and Vet students with an interest in how genomics is influencing clinical practice:
Check out the @mrc_ieu @MedicalBristol intercalation degree in 🧬Genomic Medicine 🧬2021-22
📅 deadline: 1st March
More info: bristol.ac.uk/health-science…
Daniel Higbee retweeted
People with #asthma are more vulnerable to the negative mental health impact of #lockdown. This is not explained by mental or physical comorbidities and highlights the need to provide support for #anxiety and #depression in younger people with asthma. bit.ly/3tEblYS
Daniel Higbee retweeted
Calling all Bristol followers: we have 240 Bristolians enrolled in ukcovid19study.com and want to find 70 more adults aged 30+ by 29th May. Volunteers receive either Valneva or AZ vaccine (randomised 2:1). Please retweet or otherwise let people who might be interested know.
Daniel Higbee retweeted
#COVID19 #vacciantions - One dose Pfizer BNT162b2 71.4% and one dose Oxford-AstraZeneca 80.4% vaccine effectiveness against hospitalisation in elderly & frail adults
@BristolUncover @BristolARU @BristolUni #NBTproud @ResearchNBT @uhbwNHS @Brms_Research
papers.ssrn.com/sol3/papers.…
Daniel Higbee retweeted
Asthma therapy, including monoclonal antibodies, was not associated with #COVID19 infection or hospitalisation in a UK severe asthma population. Shielding led to a reported worsening of mental health in nearly half of patients contacted (47%). bit.ly/3jImUsG
Daniel Higbee retweeted
Great to he able to share this important data. Thanks to the huge efforts of @gushamilton in particular and @BristolARU team led by @Nickmaskell1 supported by @DavidT_Arnold @CarrR and many more @NBT_ICU @BristolUni @NorthBristolNHS .
Coughing patients may pose greater health risk than previously thought, suggesting surgical masks may be inadequate to protect health workers: theguardian.com/world/2021/f… @FreshAirNHS @TheBMA @theRCN @TheDA_UK
Daniel Higbee retweeted
Good news for people with #COPD: Specialist commissioning for lung volume reduction by surgery or endobronchial valve for severe emphysema approved by @NHSEngland
england.nhs.uk/publication/l… @lunguk @BTSrespiratory @RBandH @ImperialNHLI 1/n
Daniel Higbee retweeted
3/n cont..
Conclusions #PRISm affects 8% of adults of whom ~40% report CVS comorbidity. Has shared genetic assoc with asthma & COPD. Implication for new therapeutics / screening, in particular whether this may reduce transition to #COPD & CVS disease.
medrxiv.org/content/10.1101/…
Daniel Higbee retweeted
Our new paper cont. 2/n : (PRISm)
GWAS discovered 4 associated SNPs and 8 genes. 2 SNPs have not been described with respiratory disease before. Other genetic loci identified are known to increase risk of asthma and COPD, and influence response to inhaled steroids.
Daniel Higbee retweeted
Our new paper: Preserved Ratio Impaired SpiroMetry (PRISm) in @uk_biobank More great work by @HigbeeDaniel @BristolARU @mrc_ieu @mendel_random
Similar prevalence to airflow obstruction (8% vs 7.8%) & assoc w increased CVS co-morbidity, OR of 1.26
medrxiv.org/content/10.1101/…
Daniel Higbee retweeted
Study Supports Prone Positioning in Conscious COVID-19 Patients Requiring CPAP contagionlive.com/news/study… via @Contagion_Live – at Bristol, England
Daniel Higbee retweeted
We have a new paper: looking at the role of aspirin in preventing cardiac events after pneumonia. A collaboration between @capcbristol,@BristolARU and @UEMSHealthStats. Firstly, it is recognised that pneumonia leads to stroke and MI
erj.ersjournals.com/content/…
Daniel Higbee retweeted
Frailty predicts adverse outcome in older trauma patients. Our first paper from a year's hard work in Major Trauma Geriatrics at @NorthBristolNHS. Well done team. @sarah_ibitoye @HelenDeakin8 @DrPhilipBraude
@Age_and_Ageing @GeriSoc
academic.oup.com/ageing/adva…